Abstract
To clarify the presence and origin of acetylcholine (ACh) in human blood, the ACh contents of whole blood, mononuclear (MNL) and polymorphonuclear leukocytes (PMN) were determined by a sensitive, specific radioimmunoassay. The mean (± S.E.M.) ACh contents of whole blood and MNL measured in 30 normal subjects were 1263.5 ± 149.0 and 731.0 ± 85.8 pg/ml blood, respectively. A significant correlation was observed between the ACh content of whole blood and that of MNL (r = 0.91; P < 0.001). No detectable ACh was present in PMN. These results demonstrate that ACh is present in human blood, and indicate that the major portion of plasma ACh originates from circulating MNL.
| Original language | English |
|---|---|
| Pages (from-to) | 251-258 |
| Number of pages | 8 |
| Journal | Biogenic Amines |
| Volume | 9 |
| Issue number | 4 |
| Publication status | Published - 1993 Jan 1 |
Keywords
- Acetylcholine
- Human blood
- Mononuclear leukocytes
- Radioimmunoassay
ASJC Scopus subject areas
- Neuroscience(all)
- Pharmacology
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Kawashima, K., Kajiyama, K., Fujimoto, K., Oohata, H., & Suzuki, T. (1993). Presence of acetylcholine in blood and its localization in circulating mononuclear leukocytes of humans. Biogenic Amines, 9(4), 251-258.