Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men

Akira Yokoyama, Kenro Hirata, Rieko Nakamura, Tai Omori, Takeshi Mizukami, Junko Aida, Katsuya Maruyama, Tetsuji Yokoyama

Research output: Contribution to journalArticle

Abstract

AIM To determine whether the presence of columnar-lined esophagus (CLE) is associated with the presence of METHODS The subjects were 1614 Japanese alcohol-dependent men (≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE. The authors investigated whether and to what extent there were associations between the presence of CLE and the presence of EVs, especially in the group with liver cirrhosis (LC). RESULTS CLE ≥ 5 mm in length was found in 355 subjects (≥ 30 mm in 6 of them), LC without EVs in 152 subjects, LC with EVs in 174 subjects, and EVs without LC in 6 subjects. Advanced EVs, i.e. , nodular, large or coiled forms, red color sign, or post-treatment, were found in 88 subjects. The incidence of CLE ≥ 5 mm decreased in the following order (P < 0.0001): 23.3% in the group without EVs, 17.4% in the group with small and straight EVs, and 5.7% in the group with advanced EVs. The multivariate ORs (95%CI) for EVs and advanced EVs in the group with LC were lower when CLE ≥ 5mm was present [0.46 (0.23-0.93) and 0.24 (0.08-0.74), respectively, vs 0-4 mm CLE]. CONCLUSION The presence of CLE in male Japanese alcoholics was negatively associated with the presence of EVs.

Original languageEnglish
Pages (from-to)7150-7159
Number of pages10
JournalWorld Journal of Gastroenterology
Volume23
Issue number39
DOIs
Publication statusPublished - 2017 Oct 21

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Esophageal and Gastric Varices
Alcoholics
Esophagus
Liver Cirrhosis
Esophagogastric Junction
Color
Alcohols
Incidence

Keywords

  • Alcohol
  • Columnar-lined esophagus
  • Esophageal varices
  • Hiatal hernia
  • Liver cirrhosis
  • Portal hypertension

ASJC Scopus subject areas

  • Gastroenterology

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Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men. / Yokoyama, Akira; Hirata, Kenro; Nakamura, Rieko; Omori, Tai; Mizukami, Takeshi; Aida, Junko; Maruyama, Katsuya; Yokoyama, Tetsuji.

In: World Journal of Gastroenterology, Vol. 23, No. 39, 21.10.2017, p. 7150-7159.

Research output: Contribution to journalArticle

Yokoyama, Akira ; Hirata, Kenro ; Nakamura, Rieko ; Omori, Tai ; Mizukami, Takeshi ; Aida, Junko ; Maruyama, Katsuya ; Yokoyama, Tetsuji. / Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men. In: World Journal of Gastroenterology. 2017 ; Vol. 23, No. 39. pp. 7150-7159.
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abstract = "AIM To determine whether the presence of columnar-lined esophagus (CLE) is associated with the presence of METHODS The subjects were 1614 Japanese alcohol-dependent men (≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE. The authors investigated whether and to what extent there were associations between the presence of CLE and the presence of EVs, especially in the group with liver cirrhosis (LC). RESULTS CLE ≥ 5 mm in length was found in 355 subjects (≥ 30 mm in 6 of them), LC without EVs in 152 subjects, LC with EVs in 174 subjects, and EVs without LC in 6 subjects. Advanced EVs, i.e. , nodular, large or coiled forms, red color sign, or post-treatment, were found in 88 subjects. The incidence of CLE ≥ 5 mm decreased in the following order (P < 0.0001): 23.3{\%} in the group without EVs, 17.4{\%} in the group with small and straight EVs, and 5.7{\%} in the group with advanced EVs. The multivariate ORs (95{\%}CI) for EVs and advanced EVs in the group with LC were lower when CLE ≥ 5mm was present [0.46 (0.23-0.93) and 0.24 (0.08-0.74), respectively, vs 0-4 mm CLE]. CONCLUSION The presence of CLE in male Japanese alcoholics was negatively associated with the presence of EVs.",
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T1 - Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men

AU - Yokoyama, Akira

AU - Hirata, Kenro

AU - Nakamura, Rieko

AU - Omori, Tai

AU - Mizukami, Takeshi

AU - Aida, Junko

AU - Maruyama, Katsuya

AU - Yokoyama, Tetsuji

PY - 2017/10/21

Y1 - 2017/10/21

N2 - AIM To determine whether the presence of columnar-lined esophagus (CLE) is associated with the presence of METHODS The subjects were 1614 Japanese alcohol-dependent men (≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE. The authors investigated whether and to what extent there were associations between the presence of CLE and the presence of EVs, especially in the group with liver cirrhosis (LC). RESULTS CLE ≥ 5 mm in length was found in 355 subjects (≥ 30 mm in 6 of them), LC without EVs in 152 subjects, LC with EVs in 174 subjects, and EVs without LC in 6 subjects. Advanced EVs, i.e. , nodular, large or coiled forms, red color sign, or post-treatment, were found in 88 subjects. The incidence of CLE ≥ 5 mm decreased in the following order (P < 0.0001): 23.3% in the group without EVs, 17.4% in the group with small and straight EVs, and 5.7% in the group with advanced EVs. The multivariate ORs (95%CI) for EVs and advanced EVs in the group with LC were lower when CLE ≥ 5mm was present [0.46 (0.23-0.93) and 0.24 (0.08-0.74), respectively, vs 0-4 mm CLE]. CONCLUSION The presence of CLE in male Japanese alcoholics was negatively associated with the presence of EVs.

AB - AIM To determine whether the presence of columnar-lined esophagus (CLE) is associated with the presence of METHODS The subjects were 1614 Japanese alcohol-dependent men (≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE. The authors investigated whether and to what extent there were associations between the presence of CLE and the presence of EVs, especially in the group with liver cirrhosis (LC). RESULTS CLE ≥ 5 mm in length was found in 355 subjects (≥ 30 mm in 6 of them), LC without EVs in 152 subjects, LC with EVs in 174 subjects, and EVs without LC in 6 subjects. Advanced EVs, i.e. , nodular, large or coiled forms, red color sign, or post-treatment, were found in 88 subjects. The incidence of CLE ≥ 5 mm decreased in the following order (P < 0.0001): 23.3% in the group without EVs, 17.4% in the group with small and straight EVs, and 5.7% in the group with advanced EVs. The multivariate ORs (95%CI) for EVs and advanced EVs in the group with LC were lower when CLE ≥ 5mm was present [0.46 (0.23-0.93) and 0.24 (0.08-0.74), respectively, vs 0-4 mm CLE]. CONCLUSION The presence of CLE in male Japanese alcoholics was negatively associated with the presence of EVs.

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KW - Portal hypertension

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