Abstract
AIM To determine whether the presence of columnar-lined esophagus (CLE) is associated with the presence of METHODS The subjects were 1614 Japanese alcohol-dependent men (≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE. The authors investigated whether and to what extent there were associations between the presence of CLE and the presence of EVs, especially in the group with liver cirrhosis (LC). RESULTS CLE ≥ 5 mm in length was found in 355 subjects (≥ 30 mm in 6 of them), LC without EVs in 152 subjects, LC with EVs in 174 subjects, and EVs without LC in 6 subjects. Advanced EVs, i.e. , nodular, large or coiled forms, red color sign, or post-treatment, were found in 88 subjects. The incidence of CLE ≥ 5 mm decreased in the following order (P < 0.0001): 23.3% in the group without EVs, 17.4% in the group with small and straight EVs, and 5.7% in the group with advanced EVs. The multivariate ORs (95%CI) for EVs and advanced EVs in the group with LC were lower when CLE ≥ 5mm was present [0.46 (0.23-0.93) and 0.24 (0.08-0.74), respectively, vs 0-4 mm CLE]. CONCLUSION The presence of CLE in male Japanese alcoholics was negatively associated with the presence of EVs.
| Original language | English |
|---|---|
| Pages (from-to) | 7150-7159 |
| Number of pages | 10 |
| Journal | World Journal of Gastroenterology |
| Volume | 23 |
| Issue number | 39 |
| DOIs | |
| Publication status | Published - 2017 Oct 21 |
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Keywords
- Alcohol
- Columnar-lined esophagus
- Esophageal varices
- Hiatal hernia
- Liver cirrhosis
- Portal hypertension
ASJC Scopus subject areas
- Gastroenterology
Cite this
Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men. / Yokoyama, Akira; Hirata, Kenro; Nakamura, Rieko; Omori, Tai; Mizukami, Takeshi; Aida, Junko; Maruyama, Katsuya; Yokoyama, Tetsuji.
In: World Journal of Gastroenterology, Vol. 23, No. 39, 21.10.2017, p. 7150-7159.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men
AU - Yokoyama, Akira
AU - Hirata, Kenro
AU - Nakamura, Rieko
AU - Omori, Tai
AU - Mizukami, Takeshi
AU - Aida, Junko
AU - Maruyama, Katsuya
AU - Yokoyama, Tetsuji
PY - 2017/10/21
Y1 - 2017/10/21
N2 - AIM To determine whether the presence of columnar-lined esophagus (CLE) is associated with the presence of METHODS The subjects were 1614 Japanese alcohol-dependent men (≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE. The authors investigated whether and to what extent there were associations between the presence of CLE and the presence of EVs, especially in the group with liver cirrhosis (LC). RESULTS CLE ≥ 5 mm in length was found in 355 subjects (≥ 30 mm in 6 of them), LC without EVs in 152 subjects, LC with EVs in 174 subjects, and EVs without LC in 6 subjects. Advanced EVs, i.e. , nodular, large or coiled forms, red color sign, or post-treatment, were found in 88 subjects. The incidence of CLE ≥ 5 mm decreased in the following order (P < 0.0001): 23.3% in the group without EVs, 17.4% in the group with small and straight EVs, and 5.7% in the group with advanced EVs. The multivariate ORs (95%CI) for EVs and advanced EVs in the group with LC were lower when CLE ≥ 5mm was present [0.46 (0.23-0.93) and 0.24 (0.08-0.74), respectively, vs 0-4 mm CLE]. CONCLUSION The presence of CLE in male Japanese alcoholics was negatively associated with the presence of EVs.
AB - AIM To determine whether the presence of columnar-lined esophagus (CLE) is associated with the presence of METHODS The subjects were 1614 Japanese alcohol-dependent men (≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE. The authors investigated whether and to what extent there were associations between the presence of CLE and the presence of EVs, especially in the group with liver cirrhosis (LC). RESULTS CLE ≥ 5 mm in length was found in 355 subjects (≥ 30 mm in 6 of them), LC without EVs in 152 subjects, LC with EVs in 174 subjects, and EVs without LC in 6 subjects. Advanced EVs, i.e. , nodular, large or coiled forms, red color sign, or post-treatment, were found in 88 subjects. The incidence of CLE ≥ 5 mm decreased in the following order (P < 0.0001): 23.3% in the group without EVs, 17.4% in the group with small and straight EVs, and 5.7% in the group with advanced EVs. The multivariate ORs (95%CI) for EVs and advanced EVs in the group with LC were lower when CLE ≥ 5mm was present [0.46 (0.23-0.93) and 0.24 (0.08-0.74), respectively, vs 0-4 mm CLE]. CONCLUSION The presence of CLE in male Japanese alcoholics was negatively associated with the presence of EVs.
KW - Alcohol
KW - Columnar-lined esophagus
KW - Esophageal varices
KW - Hiatal hernia
KW - Liver cirrhosis
KW - Portal hypertension
UR - http://www.scopus.com/inward/record.url?scp=85032463378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032463378&partnerID=8YFLogxK
U2 - 10.3748/wjg.v23.i39.7150
DO - 10.3748/wjg.v23.i39.7150
M3 - Article
C2 - 29093623
AN - SCOPUS:85032463378
VL - 23
SP - 7150
EP - 7159
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 39
ER -