Presence of the factor that inhibits collagen synthesis and stimulates cell proliferation in developing embryonic chick skin extracts

Shingo Tajima, Katsumi Ohyama, Ichiro Tokimitsu, Makoto Takehana

Research output: Contribution to journalArticle


The effects were studied of the extracts prepared from 10- and 18-day developing chick skins on collagen synthesis and proliferation of the monolayered fibroblasts established from 10-day skin. Cell proliferation was stimulated by both 10- and 18-day skin extracts at the concentration of 3.5 μg/ml. Collagen synthesis was suppressed by the treatment of extracts prepared from both 10- and 18-day skins at the concentration of 3.5 μg/ml, to a greater extent in 18-day extract. The results indicate that skin extracts possess factors exhibiting both a stimulating effect on cell proliferation and an inhibitory effect on collagen synthesis.

Original languageEnglish
Pages (from-to)258-260
Number of pages3
JournalJournal of Dermatological Science
Issue number3
Publication statusPublished - 1993 Dec



  • Cell proliferation
  • Collagen
  • Developing skin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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