Abstract
The effects were studied of the extracts prepared from 10- and 18-day developing chick skins on collagen synthesis and proliferation of the monolayered fibroblasts established from 10-day skin. Cell proliferation was stimulated by both 10- and 18-day skin extracts at the concentration of 3.5 μg/ml. Collagen synthesis was suppressed by the treatment of extracts prepared from both 10- and 18-day skins at the concentration of 3.5 μg/ml, to a greater extent in 18-day extract. The results indicate that skin extracts possess factors exhibiting both a stimulating effect on cell proliferation and an inhibitory effect on collagen synthesis.
| Original language | English |
|---|---|
| Pages (from-to) | 258-260 |
| Number of pages | 3 |
| Journal | Journal of Dermatological Science |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1993 |
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Keywords
- Cell proliferation
- Collagen
- Developing skin
ASJC Scopus subject areas
- Dermatology
Cite this
Presence of the factor that inhibits collagen synthesis and stimulates cell proliferation in developing embryonic chick skin extracts. / Tajima, Shingo; Ohyama, Katsumi; Tokimitsu, Ichiro; Takehana, Makoto.
In: Journal of Dermatological Science, Vol. 6, No. 3, 1993, p. 258-260.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Presence of the factor that inhibits collagen synthesis and stimulates cell proliferation in developing embryonic chick skin extracts
AU - Tajima, Shingo
AU - Ohyama, Katsumi
AU - Tokimitsu, Ichiro
AU - Takehana, Makoto
PY - 1993
Y1 - 1993
N2 - The effects were studied of the extracts prepared from 10- and 18-day developing chick skins on collagen synthesis and proliferation of the monolayered fibroblasts established from 10-day skin. Cell proliferation was stimulated by both 10- and 18-day skin extracts at the concentration of 3.5 μg/ml. Collagen synthesis was suppressed by the treatment of extracts prepared from both 10- and 18-day skins at the concentration of 3.5 μg/ml, to a greater extent in 18-day extract. The results indicate that skin extracts possess factors exhibiting both a stimulating effect on cell proliferation and an inhibitory effect on collagen synthesis.
AB - The effects were studied of the extracts prepared from 10- and 18-day developing chick skins on collagen synthesis and proliferation of the monolayered fibroblasts established from 10-day skin. Cell proliferation was stimulated by both 10- and 18-day skin extracts at the concentration of 3.5 μg/ml. Collagen synthesis was suppressed by the treatment of extracts prepared from both 10- and 18-day skins at the concentration of 3.5 μg/ml, to a greater extent in 18-day extract. The results indicate that skin extracts possess factors exhibiting both a stimulating effect on cell proliferation and an inhibitory effect on collagen synthesis.
KW - Cell proliferation
KW - Collagen
KW - Developing skin
UR - http://www.scopus.com/inward/record.url?scp=0027753978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027753978&partnerID=8YFLogxK
U2 - 10.1016/0923-1811(93)90047-S
DO - 10.1016/0923-1811(93)90047-S
M3 - Article
C2 - 8136323
AN - SCOPUS:0027753978
VL - 6
SP - 258
EP - 260
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
SN - 0923-1811
IS - 3
ER -