Presenile non-Alzheimer dementia with motor neuron disease and laminar spongiform degeneration

Masaru Mimura, Itaru Tominaga, Haruo Kashima, Masao Honda, Kenji Kosaka, Yuji Kato

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We describe the clinicopathological findings in three autopsy cases of presenile dementia with motor neuron disease. These patients had a relatively rapid course involving dementia and muscle weakness with a distal pattern of atrophy in the upper extremities. Postmortem examination revealed features of motor neuron disease and spongiform cortical degeneration. The latter change was most marked in the second layer of the frontal or temporal cortex and included minimal to mild neuronal cell loss and mild to moderate gliosis. In this report we relate these patients' laminar spongiform degeneration to three other conditions; frontal lobe dementia, primary progressive aphasia and dementia lacking a distinctive histology. These three conditions and presenile dementia with motor neuron disease may fall within the spectrum of the non-Alzheimer type frontotemporal degenerative dementia.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalNeuropathology
Volume18
Issue number1
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Motor Neuron Disease
Dementia
Alzheimer Disease
Frontal Lobe
Autopsy
Primary Progressive Aphasia
Frontotemporal Dementia
Gliosis
Muscle Weakness
Temporal Lobe
Upper Extremity
Atrophy
Histology

Keywords

  • Frontal lobe dementia
  • Motor neuron disease
  • Presenile dementia
  • Primary progressive aphasia
  • Spongiform degeneration

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Mimura, M., Tominaga, I., Kashima, H., Honda, M., Kosaka, K., & Kato, Y. (1998). Presenile non-Alzheimer dementia with motor neuron disease and laminar spongiform degeneration. Neuropathology, 18(1), 19-26.

Presenile non-Alzheimer dementia with motor neuron disease and laminar spongiform degeneration. / Mimura, Masaru; Tominaga, Itaru; Kashima, Haruo; Honda, Masao; Kosaka, Kenji; Kato, Yuji.

In: Neuropathology, Vol. 18, No. 1, 1998, p. 19-26.

Research output: Contribution to journalArticle

Mimura, M, Tominaga, I, Kashima, H, Honda, M, Kosaka, K & Kato, Y 1998, 'Presenile non-Alzheimer dementia with motor neuron disease and laminar spongiform degeneration', Neuropathology, vol. 18, no. 1, pp. 19-26.
Mimura, Masaru ; Tominaga, Itaru ; Kashima, Haruo ; Honda, Masao ; Kosaka, Kenji ; Kato, Yuji. / Presenile non-Alzheimer dementia with motor neuron disease and laminar spongiform degeneration. In: Neuropathology. 1998 ; Vol. 18, No. 1. pp. 19-26.
@article{e517c117799247bba0cf6a3383a2f70c,
title = "Presenile non-Alzheimer dementia with motor neuron disease and laminar spongiform degeneration",
abstract = "We describe the clinicopathological findings in three autopsy cases of presenile dementia with motor neuron disease. These patients had a relatively rapid course involving dementia and muscle weakness with a distal pattern of atrophy in the upper extremities. Postmortem examination revealed features of motor neuron disease and spongiform cortical degeneration. The latter change was most marked in the second layer of the frontal or temporal cortex and included minimal to mild neuronal cell loss and mild to moderate gliosis. In this report we relate these patients' laminar spongiform degeneration to three other conditions; frontal lobe dementia, primary progressive aphasia and dementia lacking a distinctive histology. These three conditions and presenile dementia with motor neuron disease may fall within the spectrum of the non-Alzheimer type frontotemporal degenerative dementia.",
keywords = "Frontal lobe dementia, Motor neuron disease, Presenile dementia, Primary progressive aphasia, Spongiform degeneration",
author = "Masaru Mimura and Itaru Tominaga and Haruo Kashima and Masao Honda and Kenji Kosaka and Yuji Kato",
year = "1998",
language = "English",
volume = "18",
pages = "19--26",
journal = "Neuropathology",
issn = "0919-6544",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Presenile non-Alzheimer dementia with motor neuron disease and laminar spongiform degeneration

AU - Mimura, Masaru

AU - Tominaga, Itaru

AU - Kashima, Haruo

AU - Honda, Masao

AU - Kosaka, Kenji

AU - Kato, Yuji

PY - 1998

Y1 - 1998

N2 - We describe the clinicopathological findings in three autopsy cases of presenile dementia with motor neuron disease. These patients had a relatively rapid course involving dementia and muscle weakness with a distal pattern of atrophy in the upper extremities. Postmortem examination revealed features of motor neuron disease and spongiform cortical degeneration. The latter change was most marked in the second layer of the frontal or temporal cortex and included minimal to mild neuronal cell loss and mild to moderate gliosis. In this report we relate these patients' laminar spongiform degeneration to three other conditions; frontal lobe dementia, primary progressive aphasia and dementia lacking a distinctive histology. These three conditions and presenile dementia with motor neuron disease may fall within the spectrum of the non-Alzheimer type frontotemporal degenerative dementia.

AB - We describe the clinicopathological findings in three autopsy cases of presenile dementia with motor neuron disease. These patients had a relatively rapid course involving dementia and muscle weakness with a distal pattern of atrophy in the upper extremities. Postmortem examination revealed features of motor neuron disease and spongiform cortical degeneration. The latter change was most marked in the second layer of the frontal or temporal cortex and included minimal to mild neuronal cell loss and mild to moderate gliosis. In this report we relate these patients' laminar spongiform degeneration to three other conditions; frontal lobe dementia, primary progressive aphasia and dementia lacking a distinctive histology. These three conditions and presenile dementia with motor neuron disease may fall within the spectrum of the non-Alzheimer type frontotemporal degenerative dementia.

KW - Frontal lobe dementia

KW - Motor neuron disease

KW - Presenile dementia

KW - Primary progressive aphasia

KW - Spongiform degeneration

UR - http://www.scopus.com/inward/record.url?scp=0031925379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031925379&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031925379

VL - 18

SP - 19

EP - 26

JO - Neuropathology

JF - Neuropathology

SN - 0919-6544

IS - 1

ER -