Abstract
PURPOSE: We reviewed our initial experience of pediatric living-donor liver transplantation (LDLT) in National Center for Child Health and Development and report the results herein. SUBJECTS AND METHODS: We have done 103 cases of LDLT during November 2005 through September 2009 in National Center for Child Health and Development. Variables including indication of liver transplantation/infectious/immunological outcome were reviewed. RESULTS: The indication for liver transplantation was cholestatic liver disease in 43.76%, followed by metabolic liver disease 24.3% and acute liver failure 18.5%. The mean age of recipient was 3.6 +/- 4.2 years and body weight was 14.4 +/- 11.1kg. Immunosuppression consisted of tacrolimus and low-dose steroids. The incidence of acute cellular rejection was 33.3%. The graft and patient survival were 92.2%. CONCLUSION: Satisfactory result can be achieved on LDLT program in National Center for Child Health and Development. The follow-up period was too short to make definitive conclusion, however, long-term observation may be necessary to collect sufficient data for the establishment of the treatment modality.
| Original language | English |
|---|---|
| Pages (from-to) | 268-274 |
| Number of pages | 7 |
| Journal | Nippon Geka Gakkai zasshi |
| Volume | 111 |
| Issue number | 4 |
| Publication status | Published - 2010 Jul |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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Present status of pediatric living-donor liver transplantation in National Center for Child Health and Development. / Kasahara, Mureo; Sakamoto, Seisuke; Shigeta, Takanobu; Fukuda, Akinari; Matsuno, Naoto; Tanaka, Hideaki; Kitano, Yoshihiro; Kuroda, Tatsuo.
In: Nippon Geka Gakkai zasshi, Vol. 111, No. 4, 07.2010, p. 268-274.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Present status of pediatric living-donor liver transplantation in National Center for Child Health and Development
AU - Kasahara, Mureo
AU - Sakamoto, Seisuke
AU - Shigeta, Takanobu
AU - Fukuda, Akinari
AU - Matsuno, Naoto
AU - Tanaka, Hideaki
AU - Kitano, Yoshihiro
AU - Kuroda, Tatsuo
PY - 2010/7
Y1 - 2010/7
N2 - PURPOSE: We reviewed our initial experience of pediatric living-donor liver transplantation (LDLT) in National Center for Child Health and Development and report the results herein. SUBJECTS AND METHODS: We have done 103 cases of LDLT during November 2005 through September 2009 in National Center for Child Health and Development. Variables including indication of liver transplantation/infectious/immunological outcome were reviewed. RESULTS: The indication for liver transplantation was cholestatic liver disease in 43.76%, followed by metabolic liver disease 24.3% and acute liver failure 18.5%. The mean age of recipient was 3.6 +/- 4.2 years and body weight was 14.4 +/- 11.1kg. Immunosuppression consisted of tacrolimus and low-dose steroids. The incidence of acute cellular rejection was 33.3%. The graft and patient survival were 92.2%. CONCLUSION: Satisfactory result can be achieved on LDLT program in National Center for Child Health and Development. The follow-up period was too short to make definitive conclusion, however, long-term observation may be necessary to collect sufficient data for the establishment of the treatment modality.
AB - PURPOSE: We reviewed our initial experience of pediatric living-donor liver transplantation (LDLT) in National Center for Child Health and Development and report the results herein. SUBJECTS AND METHODS: We have done 103 cases of LDLT during November 2005 through September 2009 in National Center for Child Health and Development. Variables including indication of liver transplantation/infectious/immunological outcome were reviewed. RESULTS: The indication for liver transplantation was cholestatic liver disease in 43.76%, followed by metabolic liver disease 24.3% and acute liver failure 18.5%. The mean age of recipient was 3.6 +/- 4.2 years and body weight was 14.4 +/- 11.1kg. Immunosuppression consisted of tacrolimus and low-dose steroids. The incidence of acute cellular rejection was 33.3%. The graft and patient survival were 92.2%. CONCLUSION: Satisfactory result can be achieved on LDLT program in National Center for Child Health and Development. The follow-up period was too short to make definitive conclusion, however, long-term observation may be necessary to collect sufficient data for the establishment of the treatment modality.
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UR - http://www.scopus.com/inward/citedby.url?scp=77955961130&partnerID=8YFLogxK
M3 - Article
C2 - 20684206
AN - SCOPUS:77955961130
VL - 111
SP - 268
EP - 274
JO - Nihon Geka Gakkai zasshi
JF - Nihon Geka Gakkai zasshi
SN - 0301-4894
IS - 4
ER -