Presynaptic M1 muscarinic receptor modulates spontaneous release of acetylcholine from rat basal forebrain slices

Takeshi Suzuki, Kazuko Fujimoto, Hisayo Oohata, Koichiro Kawashima

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Spontaneous release of acetylcholine (ACh) from rat basal forebrain slices in the presence of cholinesterase inhibitor was directly determined using a specific radioimmunoassay for ACh. The release was calcium dependent. A consistent amount of ACh release was observed throughout the experiment. Atropine (10-8 to 10-5 M) and pirenzepine (10-7 to 10-5 M) enhanced spontaneous ACh release. These findings indicate the presence of an M1 muscarinic autoreceptor that modulates spontaneous release of ACh in the rat basal forebrain.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalNeuroscience Letters
Volume84
Issue number2
DOIs
Publication statusPublished - 1988 Jan 22

Keywords

  • Acetylcholine release
  • Atropine
  • Autoreceptor
  • Basal forebrain
  • M muscarinic receptor
  • Pirenzepine
  • Radioimmunoassay

ASJC Scopus subject areas

  • Neuroscience(all)

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