Pretreatment plasma fibrinogen level correlates with tumor progression and metastasis in patients with squamous cell carcinoma of the esophagus

Hiroya Takeuchi, Shunji Ikeuchi, Yuukou Kitagawa, Atsushi Shimada, Takashi Oishi, Yoh Isobe, Kiyoshi Kubochi, Masaki Kitajima, Sumio Matsumoto

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Background: Hypercoagulation has been reported to be associated with tumor progression and a poor prognosis in various carcinomas. In this study, we examined fibrinogen levels in pretreated patients with esophageal squamous cell carcinoma (ESCC) and assessed its correlation with clinicopathological factors and prognosis in patients with ESCC. Methods: Pretreatment fibrinogen levels were examined prior to surgery or other treatments (e.g. endoscopic mucosal resection and chemoradiotherapy [CRT]) in 105 patients with primary ESCC. We investigated the association of fibrinogen levels with clinicopathological background factors and the survival of ESCC patients. Results: The plasma fibrinogen concentration (PFC) ranged from 209.4 to 781.6 mg/dL. Pretreatment PFC correlated significantly with the depth of invasion (T factor). There also existed a significant correlation between higher fibrinogen levels and lymph node metastasis (N factor) and distant organ metastasis. Patients with a higher fibrinogen level experienced a significantly worse overall survival (P = 0.006). Fibrinogen levels strongly correlated with platelet counts, white blood cell counts and tumor length. Pretreatment PFC were observed to have a significant correlation with CRT responsiveness in ESCC patients in stages II and III (P = 0.005). Conclusion: This study revealed that higher levels of fibrinogen correlated with tumor progression, metastasis and poor responsiveness to CRT in ESCC patients.

Original languageEnglish
Pages (from-to)2222-2227
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number12
Publication statusPublished - 2007



  • Chemoradiotherapy
  • Esophageal cancer
  • Fibrinogen
  • Metastasis
  • Survival

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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