Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: A 3-year follow-up of the ROAD study

N. Yoshimura, K. Nagata, S. Muraki, H. Oka, M. Yoshida, Y. Enyo, R. Kagotani, H. Hashizume, H. Yamada, Y. Ishimoto, M. Teraguchi, S. Tanaka, H. Kawaguchi, Y. Toyama, K. Nakamura, T. Akune

Research output: Contribution to journalArticle

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Abstract

The prevalence of radiographic cervical ossification of the posterior longitudinal ligament (OPLL) in 1,562 Japanese from a population-based cohort was 1.9 %. The presence of OPLL showed a significant association with the femoral neck bone mineral density (BMD), presence of diffuse idiopathic skeletal hyperostosis (DISH) and plasma pentosidine levels. Only one new case of radiographic OPLL was detected, but OPLL progressed in all affected subjects. Introduction: The purpose of this study was to clarify the prevalence and progression of radiographic OPLL and the associated factors, using the population-based cohort Research on Osteoarthritis/osteoporosis Against Disability (ROAD). Methods: In the ROAD study, 1,690 participants underwent X-ray examination of the entire spine and both knees. Radiographic OPLL, lumbar spondylosis, knee osteoarthritis and DISH were diagnosed by a single, well-experienced orthopaedic surgeon. An interviewer-administered questionnaire and tests for anthropometric measurements were administered, and the BMDs of the lumbar spine and proximal femur were determined. A new OPLL case was considered if heterotopic ossification in the posterior longitudinal ligament was absent at baseline but present during follow-up. Progression was defined as an increase in the maximum length or width of the ossification at follow-up over that at baseline. Results: Radiographic OPLL was detected in 30 (17 men, 13 women) of 1,562 individuals who underwent X-ray examination of the cervical spine (prevalence = 1.9 %). Its prevalence was significantly higher in men than in women (p = 0.007), but no association with age was observed. In a logistic regression analysis, OPLL showed a significant association with the femoral neck BMD, presence of DISH and plasma pentosidine levels. Only one new case of radiographic OPLL was detected, but OPLL progressed in all affected subjects. Conclusion: This population-based study clarified the prevalence of radiographic OPLL in the Japanese population as well as its progression. OPLL showed significant association with plasma pentosidine levels, BMD and DISH.

Original languageEnglish
Pages (from-to)1089-1098
Number of pages10
JournalOsteoporosis International
Volume25
Issue number3
DOIs
Publication statusPublished - 2014 Mar

Fingerprint

Ossification of Posterior Longitudinal Ligament
Osteoarthritis
Osteoporosis
Research
Population
Diffuse Idiopathic Skeletal Hyperostosis
Bone Density
Spine
Femur Neck
X-Rays
Spondylosis
Heterotopic Ossification
Knee Osteoarthritis

Keywords

  • Bone mineral density
  • Diffuse idiopathic skeletal hyperostosis
  • Ossification of posterior longitudinal ligament of cervical spine
  • Plasma pentosidine
  • Prevalence
  • Progression

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population : A 3-year follow-up of the ROAD study. / Yoshimura, N.; Nagata, K.; Muraki, S.; Oka, H.; Yoshida, M.; Enyo, Y.; Kagotani, R.; Hashizume, H.; Yamada, H.; Ishimoto, Y.; Teraguchi, M.; Tanaka, S.; Kawaguchi, H.; Toyama, Y.; Nakamura, K.; Akune, T.

In: Osteoporosis International, Vol. 25, No. 3, 03.2014, p. 1089-1098.

Research output: Contribution to journalArticle

Yoshimura, N, Nagata, K, Muraki, S, Oka, H, Yoshida, M, Enyo, Y, Kagotani, R, Hashizume, H, Yamada, H, Ishimoto, Y, Teraguchi, M, Tanaka, S, Kawaguchi, H, Toyama, Y, Nakamura, K & Akune, T 2014, 'Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: A 3-year follow-up of the ROAD study', Osteoporosis International, vol. 25, no. 3, pp. 1089-1098. https://doi.org/10.1007/s00198-013-2489-0
Yoshimura, N. ; Nagata, K. ; Muraki, S. ; Oka, H. ; Yoshida, M. ; Enyo, Y. ; Kagotani, R. ; Hashizume, H. ; Yamada, H. ; Ishimoto, Y. ; Teraguchi, M. ; Tanaka, S. ; Kawaguchi, H. ; Toyama, Y. ; Nakamura, K. ; Akune, T. / Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population : A 3-year follow-up of the ROAD study. In: Osteoporosis International. 2014 ; Vol. 25, No. 3. pp. 1089-1098.
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AU - Muraki, S.

AU - Oka, H.

AU - Yoshida, M.

AU - Enyo, Y.

AU - Kagotani, R.

AU - Hashizume, H.

AU - Yamada, H.

AU - Ishimoto, Y.

AU - Teraguchi, M.

AU - Tanaka, S.

AU - Kawaguchi, H.

AU - Toyama, Y.

AU - Nakamura, K.

AU - Akune, T.

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N2 - The prevalence of radiographic cervical ossification of the posterior longitudinal ligament (OPLL) in 1,562 Japanese from a population-based cohort was 1.9 %. The presence of OPLL showed a significant association with the femoral neck bone mineral density (BMD), presence of diffuse idiopathic skeletal hyperostosis (DISH) and plasma pentosidine levels. Only one new case of radiographic OPLL was detected, but OPLL progressed in all affected subjects. Introduction: The purpose of this study was to clarify the prevalence and progression of radiographic OPLL and the associated factors, using the population-based cohort Research on Osteoarthritis/osteoporosis Against Disability (ROAD). Methods: In the ROAD study, 1,690 participants underwent X-ray examination of the entire spine and both knees. Radiographic OPLL, lumbar spondylosis, knee osteoarthritis and DISH were diagnosed by a single, well-experienced orthopaedic surgeon. An interviewer-administered questionnaire and tests for anthropometric measurements were administered, and the BMDs of the lumbar spine and proximal femur were determined. A new OPLL case was considered if heterotopic ossification in the posterior longitudinal ligament was absent at baseline but present during follow-up. Progression was defined as an increase in the maximum length or width of the ossification at follow-up over that at baseline. Results: Radiographic OPLL was detected in 30 (17 men, 13 women) of 1,562 individuals who underwent X-ray examination of the cervical spine (prevalence = 1.9 %). Its prevalence was significantly higher in men than in women (p = 0.007), but no association with age was observed. In a logistic regression analysis, OPLL showed a significant association with the femoral neck BMD, presence of DISH and plasma pentosidine levels. Only one new case of radiographic OPLL was detected, but OPLL progressed in all affected subjects. Conclusion: This population-based study clarified the prevalence of radiographic OPLL in the Japanese population as well as its progression. OPLL showed significant association with plasma pentosidine levels, BMD and DISH.

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KW - Bone mineral density

KW - Diffuse idiopathic skeletal hyperostosis

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KW - Prevalence

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