Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease

Anders Øverby, Somay Y. Murayama, Hirofumi Michimae, Hidekazu Suzuki, Masayuki Suzuki, Hiroshi Serizawa, Ryo Tamura, Shinichi Nakamura, Shinichi Takahashi, Masahiko Nakamura

Research output: Contribution to journalArticle

Abstract

Background: Non-Helicobacter pylori-helicobacters (NHPH) compose a group of gram negative zoonotic bacteria that may induce in humans gastric diseases including gastritis, gastroduodenal ulcer and MALT lymphoma. Their prevalence in the general population has previously been reported to 0.1-6.2%, although such reports still remain less in number. Aims: This study aimed at estimating the prevalence of gastric NHPH in Japanese people, and further aimed at linking this to different gastric diseases and co-infection with H. pylori. Methods: Endoscopically obtained biopsy samples from 280 Japanese patients with various gastric diseases were collected. Samples were analyzed by immunohistochemistry and by species-specific PCR for detection of gastric helicobacters. Results: The total prevalence of gastric NHPH among 280 Japanese patients was 6.1%, and the prevalence of H. pylori was 65.7%. There was no significant difference in prevalence of either NHPH or H. pylori when infected with H. pylori or NHPH, respectively. NHPH infection was found to be the highest in patients with gastric MALT lymphoma and duodenal ulcer, the former being independent of co-infection with H. pylori and the latter being dependent. Conclusions: This study reports a total prevalence of 6.1% of gastric NHPH in Japanese patients, and further highlights gastric MALT lymphoma and duodenal ulcer (when co-infected with H. pylori) as important related diseases.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalDigestion
Volume95
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

Fingerprint

Stomach Diseases
Helicobacter pylori
Stomach
Marginal Zone B-Cell Lymphoma
Duodenal Ulcer
Coinfection
Helicobacter
Pylorus
Zoonoses
Helicobacter Infections
Gastritis
Gram-Negative Bacteria
Peptic Ulcer

Keywords

  • Gastritis • Ulcer
  • Japan
  • Non-Helicobacter pylori-helicobacters
  • Prevalence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Øverby, A., Murayama, S. Y., Michimae, H., Suzuki, H., Suzuki, M., Serizawa, H., ... Nakamura, M. (2017). Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease. Digestion, 95(1), 61-66. https://doi.org/10.1159/00045S2400

Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease. / Øverby, Anders; Murayama, Somay Y.; Michimae, Hirofumi; Suzuki, Hidekazu; Suzuki, Masayuki; Serizawa, Hiroshi; Tamura, Ryo; Nakamura, Shinichi; Takahashi, Shinichi; Nakamura, Masahiko.

In: Digestion, Vol. 95, No. 1, 01.01.2017, p. 61-66.

Research output: Contribution to journalArticle

Øverby, A, Murayama, SY, Michimae, H, Suzuki, H, Suzuki, M, Serizawa, H, Tamura, R, Nakamura, S, Takahashi, S & Nakamura, M 2017, 'Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease', Digestion, vol. 95, no. 1, pp. 61-66. https://doi.org/10.1159/00045S2400
Øverby A, Murayama SY, Michimae H, Suzuki H, Suzuki M, Serizawa H et al. Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease. Digestion. 2017 Jan 1;95(1):61-66. https://doi.org/10.1159/00045S2400
Øverby, Anders ; Murayama, Somay Y. ; Michimae, Hirofumi ; Suzuki, Hidekazu ; Suzuki, Masayuki ; Serizawa, Hiroshi ; Tamura, Ryo ; Nakamura, Shinichi ; Takahashi, Shinichi ; Nakamura, Masahiko. / Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease. In: Digestion. 2017 ; Vol. 95, No. 1. pp. 61-66.
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abstract = "Background: Non-Helicobacter pylori-helicobacters (NHPH) compose a group of gram negative zoonotic bacteria that may induce in humans gastric diseases including gastritis, gastroduodenal ulcer and MALT lymphoma. Their prevalence in the general population has previously been reported to 0.1-6.2{\%}, although such reports still remain less in number. Aims: This study aimed at estimating the prevalence of gastric NHPH in Japanese people, and further aimed at linking this to different gastric diseases and co-infection with H. pylori. Methods: Endoscopically obtained biopsy samples from 280 Japanese patients with various gastric diseases were collected. Samples were analyzed by immunohistochemistry and by species-specific PCR for detection of gastric helicobacters. Results: The total prevalence of gastric NHPH among 280 Japanese patients was 6.1{\%}, and the prevalence of H. pylori was 65.7{\%}. There was no significant difference in prevalence of either NHPH or H. pylori when infected with H. pylori or NHPH, respectively. NHPH infection was found to be the highest in patients with gastric MALT lymphoma and duodenal ulcer, the former being independent of co-infection with H. pylori and the latter being dependent. Conclusions: This study reports a total prevalence of 6.1{\%} of gastric NHPH in Japanese patients, and further highlights gastric MALT lymphoma and duodenal ulcer (when co-infected with H. pylori) as important related diseases.",
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AU - Suzuki, Masayuki

AU - Serizawa, Hiroshi

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