Abstract
A GAS Surveillance Study Group was organized to analyze group A streptococci (GAS) isolated from patients with acute pharyngotonsillitis, with participating pediatricians submitting swab samples between April and October 2012. Molecular analysis of emm typing and multilocus sequence typing (MLST), as well as antimicrobial susceptibility testing, were carried out for 363 GAS isolates. Strains belonging to emm1 were most prevalent (25.6%), followed in turn by emm12 (23.7%), emm28 (16.3%), and emm89 (15.3%). In emm1, 87.2% of strains, typed as ST28 or ST661, showed macrolide (ML) resistance mediated by the mef(A) gene. In emm12 (ST36 and ST465), 64.3% of strains were resistant to MLs because of mef(A) or erm(B), as was also true for 81.7% of emm28 (ST52). In emm89 (ST101 and ST646), however, such resistance was not seen. Due to the high levels of ML resistance observed, GAS isolates from individuals with penicillin allergies need to be isolated and their antimicrobial susceptibility tested, rather than automatically giving the patient a ML.
| Original language | English |
|---|---|
| Pages (from-to) | 431-435 |
| Number of pages | 5 |
| Journal | Microbial Drug Resistance |
| Volume | 20 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 Oct 1 |
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ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology
- Immunology
- Microbiology
- Medicine(all)
Cite this
Prevalence of macrolide resistance among group a streptococci isolated from pharyngotonsillitis. / Wajima, Takeaki; Chiba, Naoko; Morozumi, Miyuki; Shouji, Michi; Sunaoshi, Katsuhiko; Sugita, Kayoko; Tajima, Takeshi; Ubukata, Kimiko.
In: Microbial Drug Resistance, Vol. 20, No. 5, 01.10.2014, p. 431-435.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevalence of macrolide resistance among group a streptococci isolated from pharyngotonsillitis
AU - Wajima, Takeaki
AU - Chiba, Naoko
AU - Morozumi, Miyuki
AU - Shouji, Michi
AU - Sunaoshi, Katsuhiko
AU - Sugita, Kayoko
AU - Tajima, Takeshi
AU - Ubukata, Kimiko
PY - 2014/10/1
Y1 - 2014/10/1
N2 - A GAS Surveillance Study Group was organized to analyze group A streptococci (GAS) isolated from patients with acute pharyngotonsillitis, with participating pediatricians submitting swab samples between April and October 2012. Molecular analysis of emm typing and multilocus sequence typing (MLST), as well as antimicrobial susceptibility testing, were carried out for 363 GAS isolates. Strains belonging to emm1 were most prevalent (25.6%), followed in turn by emm12 (23.7%), emm28 (16.3%), and emm89 (15.3%). In emm1, 87.2% of strains, typed as ST28 or ST661, showed macrolide (ML) resistance mediated by the mef(A) gene. In emm12 (ST36 and ST465), 64.3% of strains were resistant to MLs because of mef(A) or erm(B), as was also true for 81.7% of emm28 (ST52). In emm89 (ST101 and ST646), however, such resistance was not seen. Due to the high levels of ML resistance observed, GAS isolates from individuals with penicillin allergies need to be isolated and their antimicrobial susceptibility tested, rather than automatically giving the patient a ML.
AB - A GAS Surveillance Study Group was organized to analyze group A streptococci (GAS) isolated from patients with acute pharyngotonsillitis, with participating pediatricians submitting swab samples between April and October 2012. Molecular analysis of emm typing and multilocus sequence typing (MLST), as well as antimicrobial susceptibility testing, were carried out for 363 GAS isolates. Strains belonging to emm1 were most prevalent (25.6%), followed in turn by emm12 (23.7%), emm28 (16.3%), and emm89 (15.3%). In emm1, 87.2% of strains, typed as ST28 or ST661, showed macrolide (ML) resistance mediated by the mef(A) gene. In emm12 (ST36 and ST465), 64.3% of strains were resistant to MLs because of mef(A) or erm(B), as was also true for 81.7% of emm28 (ST52). In emm89 (ST101 and ST646), however, such resistance was not seen. Due to the high levels of ML resistance observed, GAS isolates from individuals with penicillin allergies need to be isolated and their antimicrobial susceptibility tested, rather than automatically giving the patient a ML.
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UR - http://www.scopus.com/inward/citedby.url?scp=84907464124&partnerID=8YFLogxK
U2 - 10.1089/mdr.2013.0213
DO - 10.1089/mdr.2013.0213
M3 - Article
C2 - 24571416
AN - SCOPUS:84907464124
VL - 20
SP - 431
EP - 435
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
SN - 1076-6294
IS - 5
ER -