Prevalence of patent foramen ovale in the Japanese population - Autopsy study

Junko Kuramoto, Akio Kawamura, Tomohisa Dembo, Tokuhiro Kimura, Keiichi Fukuda, Yasunori Okada

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Patent foramen ovale (PFO) can cause ischemic stroke because of paradoxical embolism. Autopsy studies have shown that the prevalence of PFO is 25% in whites or blacks. However, there is a paucity of data on the prevalence of PFO in Asians. The aim of this study was to clarify the prevalence of PFO in the Japanese population. Methods and Results: We reviewed 52,717 autopsy reports, which were collected and edited by the Japanese Society of Pathology from 2009 to 2012. Next, we inspected consecutive 103 formalin-fixed specimens that had already been examined by certified pathologists from 2009 to 2013 to find PFO and atrial septal aneurysm (ASA). ASA was defined as ≥10 mm protrusion of the septum into the left or the right atrium. In the database of the Japanese Society of Pathology, the incidence of PFO was 0.08% (43/52,717). Inspection of heart specimens disclosed that the prevalence of PFO was 13.6% (14/103). None of the PFO cases was reported at the original autopsy. PFO was more frequently found in the subjects with ASA (50%) than in those without ASA (9.7%) (P=0.004). Conclusions: PFO is under-reported in autopsy reports. Re-evaluation of heart specimens disclosed that the prevalence of PFO was 13.6%. The prevalence was lower than reported in the past.

Original languageEnglish
Pages (from-to)2038-2042
Number of pages5
JournalCirculation Journal
Volume79
Issue number9
DOIs
Publication statusPublished - 2015 Aug 25

Keywords

  • Atrial septal aneurysm
  • Cryptogenic stroke
  • Ethnicity
  • Patent foramen ovale

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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