Prevalence of patent foramen ovale in the Japanese population - Autopsy study

Junko Kuramoto, Akio Kawamura, Tomohisa Dembo, Tokuhiro Kimura, Keiichi Fukuda, Yasunori Okada

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Patent foramen ovale (PFO) can cause ischemic stroke because of paradoxical embolism. Autopsy studies have shown that the prevalence of PFO is 25% in whites or blacks. However, there is a paucity of data on the prevalence of PFO in Asians. The aim of this study was to clarify the prevalence of PFO in the Japanese population. Methods and Results: We reviewed 52,717 autopsy reports, which were collected and edited by the Japanese Society of Pathology from 2009 to 2012. Next, we inspected consecutive 103 formalin-fixed specimens that had already been examined by certified pathologists from 2009 to 2013 to find PFO and atrial septal aneurysm (ASA). ASA was defined as ≥10 mm protrusion of the septum into the left or the right atrium. In the database of the Japanese Society of Pathology, the incidence of PFO was 0.08% (43/52,717). Inspection of heart specimens disclosed that the prevalence of PFO was 13.6% (14/103). None of the PFO cases was reported at the original autopsy. PFO was more frequently found in the subjects with ASA (50%) than in those without ASA (9.7%) (P=0.004). Conclusions: PFO is under-reported in autopsy reports. Re-evaluation of heart specimens disclosed that the prevalence of PFO was 13.6%. The prevalence was lower than reported in the past.

Original languageEnglish
Pages (from-to)2038-2042
Number of pages5
JournalCirculation Journal
Volume79
Issue number9
DOIs
Publication statusPublished - 2015 Aug 25

Fingerprint

Patent Foramen Ovale
Autopsy
Population
Aneurysm
Paradoxical Embolism
Pathology
Heart Atria
Formaldehyde
Stroke
Databases

Keywords

  • Atrial septal aneurysm
  • Cryptogenic stroke
  • Ethnicity
  • Patent foramen ovale

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prevalence of patent foramen ovale in the Japanese population - Autopsy study. / Kuramoto, Junko; Kawamura, Akio; Dembo, Tomohisa; Kimura, Tokuhiro; Fukuda, Keiichi; Okada, Yasunori.

In: Circulation Journal, Vol. 79, No. 9, 25.08.2015, p. 2038-2042.

Research output: Contribution to journalArticle

Kuramoto, J, Kawamura, A, Dembo, T, Kimura, T, Fukuda, K & Okada, Y 2015, 'Prevalence of patent foramen ovale in the Japanese population - Autopsy study', Circulation Journal, vol. 79, no. 9, pp. 2038-2042. https://doi.org/10.1253/circj.CJ-15-0197
Kuramoto, Junko ; Kawamura, Akio ; Dembo, Tomohisa ; Kimura, Tokuhiro ; Fukuda, Keiichi ; Okada, Yasunori. / Prevalence of patent foramen ovale in the Japanese population - Autopsy study. In: Circulation Journal. 2015 ; Vol. 79, No. 9. pp. 2038-2042.
@article{f64214761e9142e09e215a3415f41117,
title = "Prevalence of patent foramen ovale in the Japanese population - Autopsy study",
abstract = "Background: Patent foramen ovale (PFO) can cause ischemic stroke because of paradoxical embolism. Autopsy studies have shown that the prevalence of PFO is 25{\%} in whites or blacks. However, there is a paucity of data on the prevalence of PFO in Asians. The aim of this study was to clarify the prevalence of PFO in the Japanese population. Methods and Results: We reviewed 52,717 autopsy reports, which were collected and edited by the Japanese Society of Pathology from 2009 to 2012. Next, we inspected consecutive 103 formalin-fixed specimens that had already been examined by certified pathologists from 2009 to 2013 to find PFO and atrial septal aneurysm (ASA). ASA was defined as ≥10 mm protrusion of the septum into the left or the right atrium. In the database of the Japanese Society of Pathology, the incidence of PFO was 0.08{\%} (43/52,717). Inspection of heart specimens disclosed that the prevalence of PFO was 13.6{\%} (14/103). None of the PFO cases was reported at the original autopsy. PFO was more frequently found in the subjects with ASA (50{\%}) than in those without ASA (9.7{\%}) (P=0.004). Conclusions: PFO is under-reported in autopsy reports. Re-evaluation of heart specimens disclosed that the prevalence of PFO was 13.6{\%}. The prevalence was lower than reported in the past.",
keywords = "Atrial septal aneurysm, Cryptogenic stroke, Ethnicity, Patent foramen ovale",
author = "Junko Kuramoto and Akio Kawamura and Tomohisa Dembo and Tokuhiro Kimura and Keiichi Fukuda and Yasunori Okada",
year = "2015",
month = "8",
day = "25",
doi = "10.1253/circj.CJ-15-0197",
language = "English",
volume = "79",
pages = "2038--2042",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "9",

}

TY - JOUR

T1 - Prevalence of patent foramen ovale in the Japanese population - Autopsy study

AU - Kuramoto, Junko

AU - Kawamura, Akio

AU - Dembo, Tomohisa

AU - Kimura, Tokuhiro

AU - Fukuda, Keiichi

AU - Okada, Yasunori

PY - 2015/8/25

Y1 - 2015/8/25

N2 - Background: Patent foramen ovale (PFO) can cause ischemic stroke because of paradoxical embolism. Autopsy studies have shown that the prevalence of PFO is 25% in whites or blacks. However, there is a paucity of data on the prevalence of PFO in Asians. The aim of this study was to clarify the prevalence of PFO in the Japanese population. Methods and Results: We reviewed 52,717 autopsy reports, which were collected and edited by the Japanese Society of Pathology from 2009 to 2012. Next, we inspected consecutive 103 formalin-fixed specimens that had already been examined by certified pathologists from 2009 to 2013 to find PFO and atrial septal aneurysm (ASA). ASA was defined as ≥10 mm protrusion of the septum into the left or the right atrium. In the database of the Japanese Society of Pathology, the incidence of PFO was 0.08% (43/52,717). Inspection of heart specimens disclosed that the prevalence of PFO was 13.6% (14/103). None of the PFO cases was reported at the original autopsy. PFO was more frequently found in the subjects with ASA (50%) than in those without ASA (9.7%) (P=0.004). Conclusions: PFO is under-reported in autopsy reports. Re-evaluation of heart specimens disclosed that the prevalence of PFO was 13.6%. The prevalence was lower than reported in the past.

AB - Background: Patent foramen ovale (PFO) can cause ischemic stroke because of paradoxical embolism. Autopsy studies have shown that the prevalence of PFO is 25% in whites or blacks. However, there is a paucity of data on the prevalence of PFO in Asians. The aim of this study was to clarify the prevalence of PFO in the Japanese population. Methods and Results: We reviewed 52,717 autopsy reports, which were collected and edited by the Japanese Society of Pathology from 2009 to 2012. Next, we inspected consecutive 103 formalin-fixed specimens that had already been examined by certified pathologists from 2009 to 2013 to find PFO and atrial septal aneurysm (ASA). ASA was defined as ≥10 mm protrusion of the septum into the left or the right atrium. In the database of the Japanese Society of Pathology, the incidence of PFO was 0.08% (43/52,717). Inspection of heart specimens disclosed that the prevalence of PFO was 13.6% (14/103). None of the PFO cases was reported at the original autopsy. PFO was more frequently found in the subjects with ASA (50%) than in those without ASA (9.7%) (P=0.004). Conclusions: PFO is under-reported in autopsy reports. Re-evaluation of heart specimens disclosed that the prevalence of PFO was 13.6%. The prevalence was lower than reported in the past.

KW - Atrial septal aneurysm

KW - Cryptogenic stroke

KW - Ethnicity

KW - Patent foramen ovale

UR - http://www.scopus.com/inward/record.url?scp=84940054894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940054894&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-15-0197

DO - 10.1253/circj.CJ-15-0197

M3 - Article

C2 - 26084379

AN - SCOPUS:84940054894

VL - 79

SP - 2038

EP - 2042

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 9

ER -