Prevention of joint destruction in patients with high disease activity or high C-reactive protein levels: Post hoc analysis of the GO-FORTH study

Yoshiya Tanaka, Masayoshi Harigai, Tsutomu Takeuchi, Hisashi Yamanaka, Naoki Ishiguro, Kazuhiko Yamamoto, Yutaka Ishii, Hiroshi Nakajima, Daniel Baker, Nobuyuki Miyasaka, Takao Koike

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3 Citations (Scopus)

Abstract

Objectives: To assess the influence of golimumab dosage and disease activity on joint destruction in patients with active rheumatoid arthritis (RA) in the GO-FORTH study.Methods: Efficacy was compared among groups given basal methotrexate plus placebo, golimumab (50 mg), or golimumab (100 mg) with stratification by high (HDA) or moderate (MDA) baseline disease activity and by high or low baseline C-reactive protein (CRP).Results: Among HDA or high CRP patients, the mean change of the total Sharp score was 3.48 and 3.41 in the placebo group, 1.94 and 2.71 in the 50 mg group, and 0.39 and 1.15 in the 100 mg group, respectively. The percentage of progression-free patients with HDA or high CRP was 40.4% and 40.0%, 43.1% and 38.2%, and 69.8% and 61.5%, respectively. Among MDA or low CRP patients, both golimumab doses showed similar prevention of joint destruction. Among HDA or high CRP patients, a shorter disease duration and higher TSS/disease duration ratio were associated with joint destruction.Conclusion: Both doses of golimumab (50 or 100 mg) prevented joint destruction in MDA or low CRP patients, but 100 mg was better for HDA or high CRP patients with a shorter disease duration or higher TSS/disease duration ratio.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalModern rheumatology
Volume26
Issue number3
DOIs
Publication statusPublished - 2016 May 3

Keywords

  • Golimumab
  • High disease activity
  • Japanese
  • Rheumatoid arthritis
  • Total Sharp score

ASJC Scopus subject areas

  • Rheumatology

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    Tanaka, Y., Harigai, M., Takeuchi, T., Yamanaka, H., Ishiguro, N., Yamamoto, K., Ishii, Y., Nakajima, H., Baker, D., Miyasaka, N., & Koike, T. (2016). Prevention of joint destruction in patients with high disease activity or high C-reactive protein levels: Post hoc analysis of the GO-FORTH study. Modern rheumatology, 26(3), 323-330. https://doi.org/10.3109/14397595.2015.1086041