Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide

Koji Hase, Rena Kasimu, Purusotam Basnet, Shigetoshi Kadota, Tsuneo Namba

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The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl4)-induced necrosis. A further study was carried out to isolate the active constituent. Activity guided fractionation of the extract and chemical analysis gave us lithospermate B (a salt of lithospermic acid B), a tetramer of caffeic acid. Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl4 or D-galactosamine (D-GalN)/lipopolysaccharide (LPS).

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalPlanta Medica
Issue number1
Publication statusPublished - 1997 Mar 22
Externally publishedYes



  • Labiatae
  • Salvia miltiorhiza
  • carbon tetrachloride
  • hepatoprotective effect
  • lipopolysaccharide
  • lithospermate B

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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