Preventive trial of preheating administration of oxaliplatin-diluted solution in combination with a hot compress for oxaliplatin-induced venous pain

Risa Miyajima, Hitoshi Kawazoe, Kikue Tsuneoka, Mitsuko Fujiwara, Yoh Kojima, Yoshihiro Yakushijin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Venous pain induced by oxaliplatin (L-OHP) is a clinical problem in relation to adherence in the CapeOX regimen. We investigated the preventive effect of nursing care preheating administration of L-OHP a hot compress for colorectal cancer patients who received L-OHP via the peripheral venous route between January 2010 and January 2011. L-OHP was diluted in 500 mL of 5% glucose and administered by 2 hours. We evaluated a total of 64 courses among fifteen patients. The presence of any symptoms, any pain with or without touch, and some symptoms of numbness at the L-OHP-administered arm were defined as phlebitis, venous pain, and acute peripheral neuropathy, respectively. The prevalence of phlebitis, venous pain, and acute peripheral neuropathy in the nursing care group was 56.5%, 32.6%, and 25.8%, respectively, which was not significantly less in comparison with the control group (72.2%, 38.9%, and 54.5%, respectively). These results suggest that both types of nursing care, preheating administration and a hot compress, may be effective for the relief of acute peripheral neuropathy induced by L-OHP.

Original languageEnglish
Pages (from-to)537-540
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume40
Issue number4
Publication statusPublished - 2013 Apr 1
Externally publishedYes

Keywords

  • Hot compress
  • Oxaliplatin
  • Preheating administration
  • Venous pain

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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