Preventive use of diltiazem to suppress supraventricular tachyarrhythmia in the patients after esophagectomy

Muneaki Shimada, Harumi Namai, Hiroshi Morisaki, Ryoichi Ochiai, Junzo Takeda, Kazuaki Fukushima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We investigated the efficacy of preventive use of diltiazem to suppress supraventricular tachyarrhythmia such as paroxysmal atrial tachycardia (PAT) and atrial fibrillation (Af) in the patients who underwent transthoracic esophagectomy. We divided 52 patients into 2 groups; the diltiazem group (n=26) and the control group (n=26). In the diltiazem group continuous intravenous infusion of diltiazem (1-3mcg · kg-1 · min-1) was started when the patient's heart rate remained over 110 · min-1 without any predisposing factor. On the other hand, in the control group we did not use it preventively. In both groups, we did not restrict the use of antiarrhythmic agents if necessary. We recognized PAT or Af in the control group (54 %) more often than in the diltiazem group (19 %). PAT or Af seldom occurred after the 4th post-operative day in the both groups. Serum diltiazem concentrations of 9 patients after about 10 hours infusion showed great variation (between 30 and 250 ng · ml-1). In 7 of them the diltiazem concentration increased as the duration of infusion was prolonged. However, we did not observe bradyarrhythmia. We consider that the continuous diltiazem infusion is effective in suppressing supraventricular tachyarrhythmia after esophagectomy.

Original languageEnglish
Pages (from-to)658-663
Number of pages6
JournalJapanese Journal of Anesthesiology
Volume46
Issue number5
Publication statusPublished - 1997 May

Fingerprint

Esophagectomy
Diltiazem
Tachycardia
Paroxysmal Tachycardia
Atrial Fibrillation
Control Groups
Bradycardia
Intravenous Infusions
Causality
Heart Rate
Serum

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Preventive use of diltiazem to suppress supraventricular tachyarrhythmia in the patients after esophagectomy. / Shimada, Muneaki; Namai, Harumi; Morisaki, Hiroshi; Ochiai, Ryoichi; Takeda, Junzo; Fukushima, Kazuaki.

In: Japanese Journal of Anesthesiology, Vol. 46, No. 5, 05.1997, p. 658-663.

Research output: Contribution to journalArticle

Shimada, Muneaki ; Namai, Harumi ; Morisaki, Hiroshi ; Ochiai, Ryoichi ; Takeda, Junzo ; Fukushima, Kazuaki. / Preventive use of diltiazem to suppress supraventricular tachyarrhythmia in the patients after esophagectomy. In: Japanese Journal of Anesthesiology. 1997 ; Vol. 46, No. 5. pp. 658-663.
@article{99fa958e3e834faeb0a973dfa6dd9354,
title = "Preventive use of diltiazem to suppress supraventricular tachyarrhythmia in the patients after esophagectomy",
abstract = "We investigated the efficacy of preventive use of diltiazem to suppress supraventricular tachyarrhythmia such as paroxysmal atrial tachycardia (PAT) and atrial fibrillation (Af) in the patients who underwent transthoracic esophagectomy. We divided 52 patients into 2 groups; the diltiazem group (n=26) and the control group (n=26). In the diltiazem group continuous intravenous infusion of diltiazem (1-3mcg · kg-1 · min-1) was started when the patient's heart rate remained over 110 · min-1 without any predisposing factor. On the other hand, in the control group we did not use it preventively. In both groups, we did not restrict the use of antiarrhythmic agents if necessary. We recognized PAT or Af in the control group (54 {\%}) more often than in the diltiazem group (19 {\%}). PAT or Af seldom occurred after the 4th post-operative day in the both groups. Serum diltiazem concentrations of 9 patients after about 10 hours infusion showed great variation (between 30 and 250 ng · ml-1). In 7 of them the diltiazem concentration increased as the duration of infusion was prolonged. However, we did not observe bradyarrhythmia. We consider that the continuous diltiazem infusion is effective in suppressing supraventricular tachyarrhythmia after esophagectomy.",
author = "Muneaki Shimada and Harumi Namai and Hiroshi Morisaki and Ryoichi Ochiai and Junzo Takeda and Kazuaki Fukushima",
year = "1997",
month = "5",
language = "English",
volume = "46",
pages = "658--663",
journal = "Japanese Journal of Anesthesiology",
issn = "0021-4892",
publisher = "Kokuseido Publishing Co. Ltd",
number = "5",

}

TY - JOUR

T1 - Preventive use of diltiazem to suppress supraventricular tachyarrhythmia in the patients after esophagectomy

AU - Shimada, Muneaki

AU - Namai, Harumi

AU - Morisaki, Hiroshi

AU - Ochiai, Ryoichi

AU - Takeda, Junzo

AU - Fukushima, Kazuaki

PY - 1997/5

Y1 - 1997/5

N2 - We investigated the efficacy of preventive use of diltiazem to suppress supraventricular tachyarrhythmia such as paroxysmal atrial tachycardia (PAT) and atrial fibrillation (Af) in the patients who underwent transthoracic esophagectomy. We divided 52 patients into 2 groups; the diltiazem group (n=26) and the control group (n=26). In the diltiazem group continuous intravenous infusion of diltiazem (1-3mcg · kg-1 · min-1) was started when the patient's heart rate remained over 110 · min-1 without any predisposing factor. On the other hand, in the control group we did not use it preventively. In both groups, we did not restrict the use of antiarrhythmic agents if necessary. We recognized PAT or Af in the control group (54 %) more often than in the diltiazem group (19 %). PAT or Af seldom occurred after the 4th post-operative day in the both groups. Serum diltiazem concentrations of 9 patients after about 10 hours infusion showed great variation (between 30 and 250 ng · ml-1). In 7 of them the diltiazem concentration increased as the duration of infusion was prolonged. However, we did not observe bradyarrhythmia. We consider that the continuous diltiazem infusion is effective in suppressing supraventricular tachyarrhythmia after esophagectomy.

AB - We investigated the efficacy of preventive use of diltiazem to suppress supraventricular tachyarrhythmia such as paroxysmal atrial tachycardia (PAT) and atrial fibrillation (Af) in the patients who underwent transthoracic esophagectomy. We divided 52 patients into 2 groups; the diltiazem group (n=26) and the control group (n=26). In the diltiazem group continuous intravenous infusion of diltiazem (1-3mcg · kg-1 · min-1) was started when the patient's heart rate remained over 110 · min-1 without any predisposing factor. On the other hand, in the control group we did not use it preventively. In both groups, we did not restrict the use of antiarrhythmic agents if necessary. We recognized PAT or Af in the control group (54 %) more often than in the diltiazem group (19 %). PAT or Af seldom occurred after the 4th post-operative day in the both groups. Serum diltiazem concentrations of 9 patients after about 10 hours infusion showed great variation (between 30 and 250 ng · ml-1). In 7 of them the diltiazem concentration increased as the duration of infusion was prolonged. However, we did not observe bradyarrhythmia. We consider that the continuous diltiazem infusion is effective in suppressing supraventricular tachyarrhythmia after esophagectomy.

UR - http://www.scopus.com/inward/record.url?scp=0031006452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031006452&partnerID=8YFLogxK

M3 - Article

C2 - 9185464

AN - SCOPUS:0031006452

VL - 46

SP - 658

EP - 663

JO - Japanese Journal of Anesthesiology

JF - Japanese Journal of Anesthesiology

SN - 0021-4892

IS - 5

ER -