Primary aldosteronism

Functional histopathology and long-term follow-up after unilateral adrenalectomy

Cristina Volpe, Bertil Hamberger, Anders Höög, Kuniaki Mukai, Jan Calissendorff, Hans Wahrenberg, Jan Zedenius, Marja Thorén

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objectives To investigate the long-term outcome after unilateral adrenalectomy in patients with primary aldosteronism (PA) and to establish the role of functional pathology for the final diagnosis of aldosterone-producing adenoma (APA) or hyperplasia. Design A single-centre, retrospective cohort study in a hospital setting. Patients Consecutive patients with PA, n = 120, who underwent unilateral adrenalectomy between 1985 and 2010. Preoperative and postoperative data were analysed. To indicate the site of aldosterone secretion in the resected adrenal, we added functional methods to routine histopathology, using in situ hybridization and immunohistochemistry to detect the presence of enzymes needed for aldosterone (CYP11B2) and cortisol (CYP11B1, CYP17A1) synthesis. Results The median follow-up was 5 years and the cure rate of PA 91%. Hypertension was improved in 97% and normalized in 38%. Functional histopathology changed the final diagnosis from APA to hyperplasia in 6 cases (7%). Five of these had no expression of or staining for aldosterone synthase in the adenoma, but only in nodules in the adjacent cortex. All except one APA patient were cured of PA. They had lower preoperative serum potassium and higher 24-h urinary aldosterone than patients with hyperplasia. Among patients with hyperplasia 16 of 26 were cured. Conclusions Most patients were cured of PA by unilateral adrenalectomy. Almost all noncured benefitted from the operation as the blood pressure improved. Functional histopathology proved helpful in the distinction between APA and hyperplasia, and we recommend that functional histopathology should be added to routine histopathology to improve the diagnostic evaluation and aid in tailoring the follow-up.

Original languageEnglish
Pages (from-to)639-647
Number of pages9
JournalClinical Endocrinology
Volume82
Issue number5
DOIs
Publication statusPublished - 2015 May 1

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Hyperaldosteronism
Adrenalectomy
Aldosterone
Adenoma
Hyperplasia
Cytochrome P-450 CYP11B2
Steroid 11-beta-Hydroxylase
In Situ Hybridization
Hydrocortisone
Potassium
Cohort Studies
Retrospective Studies
Immunohistochemistry
Pathology
Staining and Labeling
Blood Pressure
Hypertension
Enzymes
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Volpe, C., Hamberger, B., Höög, A., Mukai, K., Calissendorff, J., Wahrenberg, H., ... Thorén, M. (2015). Primary aldosteronism: Functional histopathology and long-term follow-up after unilateral adrenalectomy. Clinical Endocrinology, 82(5), 639-647. https://doi.org/10.1111/cen.12645

Primary aldosteronism : Functional histopathology and long-term follow-up after unilateral adrenalectomy. / Volpe, Cristina; Hamberger, Bertil; Höög, Anders; Mukai, Kuniaki; Calissendorff, Jan; Wahrenberg, Hans; Zedenius, Jan; Thorén, Marja.

In: Clinical Endocrinology, Vol. 82, No. 5, 01.05.2015, p. 639-647.

Research output: Contribution to journalArticle

Volpe, C, Hamberger, B, Höög, A, Mukai, K, Calissendorff, J, Wahrenberg, H, Zedenius, J & Thorén, M 2015, 'Primary aldosteronism: Functional histopathology and long-term follow-up after unilateral adrenalectomy', Clinical Endocrinology, vol. 82, no. 5, pp. 639-647. https://doi.org/10.1111/cen.12645
Volpe, Cristina ; Hamberger, Bertil ; Höög, Anders ; Mukai, Kuniaki ; Calissendorff, Jan ; Wahrenberg, Hans ; Zedenius, Jan ; Thorén, Marja. / Primary aldosteronism : Functional histopathology and long-term follow-up after unilateral adrenalectomy. In: Clinical Endocrinology. 2015 ; Vol. 82, No. 5. pp. 639-647.
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