Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan

Hiroto Tsuboi, Hiromitsu Asashima, Chinatsu Takai, Shinya Hagiwara, Chihiro Hagiya, Masahiro Yokosawa, Tomoya Hirota, Hisanori Umehara, Atsushi Kawakami, Hideki Nakamura, Hajime Sano, Kazuo Tsubota, Yoko Ogawa, Etsuko Takamura, Ichiro Saito, Hiroko Inoue, Seiji Nakamura, Masafumi Moriyama, Tsutomu Takeuchi, Yoshiya TanakaShintaro Hirata, Tsuneyo Mimori, Hajime Yoshifuji, Akiko Ohta, Isao Matsumoto, Takayuki Sumida

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective. To characterize the epidemiology of Sjögren's syndrome (SS), including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets, and treatment used in Japan. Methods. The Research Team for Autoimmune Diseases, the Research Program for Intractable Disease by the Ministry of Health, Labor and Welfare conducted primary and secondary surveys on epidemiology of SS in 2011. The primary survey covered 4,729 out of 14,095 Japan-wide Hospital Departments to investigate the prevalence of SS. The secondary survey encompassed 214 Hospital Departments that agreed to the survey, to characterize disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets, and treatments. Results. The number of patients with SS in Japan estimated by the primary survey was 68,483. The secondary survey involving data collected from 2,195 SS patients from 98 Hospital Departments showed that the mean age of patients was 60.8 ± 15.2 years, male/female ratio was 1/17.4, primary/secondary SS was about 60%/40% and glandular/extra-glandular form in primary SS was about 70%/25%. The satisfaction rate was 53.8% for the 1999 revised Japanese Ministry of Health criteria for the diagnosis of SS, 47.7% for the 2002 American-European Consensus Group classification criteria for SS and 49.6% for 2012 American College of Rheumatology classification criteria for SS. Corticosteroids were used by 752 of 2,195 patients (34%), immunosuppressants by 358 patients (16%), biologics by 68 patients (3%) and secretagogues by 695 patients (32%). Conclusion. The surveys provided valuable information on the epidemiology of SS including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets and treatments used today in Japan.

Original languageEnglish
Pages (from-to)464-470
Number of pages7
JournalModern Rheumatology
Volume24
Issue number3
DOIs
Publication statusPublished - 2014

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Japan
Epidemiology
Hospital Departments
Surveys and Questionnaires
Health
Immunosuppressive Agents
Biological Products
Research
Autoimmune Diseases
Consensus
Adrenal Cortex Hormones
Therapeutics

Keywords

  • Criteria
  • Epidemiology
  • Extra-glandular form
  • Glandular form
  • Sjögren's syndrome
  • Treatment

ASJC Scopus subject areas

  • Rheumatology
  • Medicine(all)

Cite this

Tsuboi, H., Asashima, H., Takai, C., Hagiwara, S., Hagiya, C., Yokosawa, M., ... Sumida, T. (2014). Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan. Modern Rheumatology, 24(3), 464-470. https://doi.org/10.3109/14397595.2013.843765

Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan. / Tsuboi, Hiroto; Asashima, Hiromitsu; Takai, Chinatsu; Hagiwara, Shinya; Hagiya, Chihiro; Yokosawa, Masahiro; Hirota, Tomoya; Umehara, Hisanori; Kawakami, Atsushi; Nakamura, Hideki; Sano, Hajime; Tsubota, Kazuo; Ogawa, Yoko; Takamura, Etsuko; Saito, Ichiro; Inoue, Hiroko; Nakamura, Seiji; Moriyama, Masafumi; Takeuchi, Tsutomu; Tanaka, Yoshiya; Hirata, Shintaro; Mimori, Tsuneyo; Yoshifuji, Hajime; Ohta, Akiko; Matsumoto, Isao; Sumida, Takayuki.

In: Modern Rheumatology, Vol. 24, No. 3, 2014, p. 464-470.

Research output: Contribution to journalArticle

Tsuboi, H, Asashima, H, Takai, C, Hagiwara, S, Hagiya, C, Yokosawa, M, Hirota, T, Umehara, H, Kawakami, A, Nakamura, H, Sano, H, Tsubota, K, Ogawa, Y, Takamura, E, Saito, I, Inoue, H, Nakamura, S, Moriyama, M, Takeuchi, T, Tanaka, Y, Hirata, S, Mimori, T, Yoshifuji, H, Ohta, A, Matsumoto, I & Sumida, T 2014, 'Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan', Modern Rheumatology, vol. 24, no. 3, pp. 464-470. https://doi.org/10.3109/14397595.2013.843765
Tsuboi H, Asashima H, Takai C, Hagiwara S, Hagiya C, Yokosawa M et al. Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan. Modern Rheumatology. 2014;24(3):464-470. https://doi.org/10.3109/14397595.2013.843765
Tsuboi, Hiroto ; Asashima, Hiromitsu ; Takai, Chinatsu ; Hagiwara, Shinya ; Hagiya, Chihiro ; Yokosawa, Masahiro ; Hirota, Tomoya ; Umehara, Hisanori ; Kawakami, Atsushi ; Nakamura, Hideki ; Sano, Hajime ; Tsubota, Kazuo ; Ogawa, Yoko ; Takamura, Etsuko ; Saito, Ichiro ; Inoue, Hiroko ; Nakamura, Seiji ; Moriyama, Masafumi ; Takeuchi, Tsutomu ; Tanaka, Yoshiya ; Hirata, Shintaro ; Mimori, Tsuneyo ; Yoshifuji, Hajime ; Ohta, Akiko ; Matsumoto, Isao ; Sumida, Takayuki. / Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan. In: Modern Rheumatology. 2014 ; Vol. 24, No. 3. pp. 464-470.
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abstract = "Objective. To characterize the epidemiology of Sj{\"o}gren's syndrome (SS), including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets, and treatment used in Japan. Methods. The Research Team for Autoimmune Diseases, the Research Program for Intractable Disease by the Ministry of Health, Labor and Welfare conducted primary and secondary surveys on epidemiology of SS in 2011. The primary survey covered 4,729 out of 14,095 Japan-wide Hospital Departments to investigate the prevalence of SS. The secondary survey encompassed 214 Hospital Departments that agreed to the survey, to characterize disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets, and treatments. Results. The number of patients with SS in Japan estimated by the primary survey was 68,483. The secondary survey involving data collected from 2,195 SS patients from 98 Hospital Departments showed that the mean age of patients was 60.8 ± 15.2 years, male/female ratio was 1/17.4, primary/secondary SS was about 60{\%}/40{\%} and glandular/extra-glandular form in primary SS was about 70{\%}/25{\%}. The satisfaction rate was 53.8{\%} for the 1999 revised Japanese Ministry of Health criteria for the diagnosis of SS, 47.7{\%} for the 2002 American-European Consensus Group classification criteria for SS and 49.6{\%} for 2012 American College of Rheumatology classification criteria for SS. Corticosteroids were used by 752 of 2,195 patients (34{\%}), immunosuppressants by 358 patients (16{\%}), biologics by 68 patients (3{\%}) and secretagogues by 695 patients (32{\%}). Conclusion. The surveys provided valuable information on the epidemiology of SS including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets and treatments used today in Japan.",
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author = "Hiroto Tsuboi and Hiromitsu Asashima and Chinatsu Takai and Shinya Hagiwara and Chihiro Hagiya and Masahiro Yokosawa and Tomoya Hirota and Hisanori Umehara and Atsushi Kawakami and Hideki Nakamura and Hajime Sano and Kazuo Tsubota and Yoko Ogawa and Etsuko Takamura and Ichiro Saito and Hiroko Inoue and Seiji Nakamura and Masafumi Moriyama and Tsutomu Takeuchi and Yoshiya Tanaka and Shintaro Hirata and Tsuneyo Mimori and Hajime Yoshifuji and Akiko Ohta and Isao Matsumoto and Takayuki Sumida",
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T1 - Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan

AU - Tsuboi, Hiroto

AU - Asashima, Hiromitsu

AU - Takai, Chinatsu

AU - Hagiwara, Shinya

AU - Hagiya, Chihiro

AU - Yokosawa, Masahiro

AU - Hirota, Tomoya

AU - Umehara, Hisanori

AU - Kawakami, Atsushi

AU - Nakamura, Hideki

AU - Sano, Hajime

AU - Tsubota, Kazuo

AU - Ogawa, Yoko

AU - Takamura, Etsuko

AU - Saito, Ichiro

AU - Inoue, Hiroko

AU - Nakamura, Seiji

AU - Moriyama, Masafumi

AU - Takeuchi, Tsutomu

AU - Tanaka, Yoshiya

AU - Hirata, Shintaro

AU - Mimori, Tsuneyo

AU - Yoshifuji, Hajime

AU - Ohta, Akiko

AU - Matsumoto, Isao

AU - Sumida, Takayuki

PY - 2014

Y1 - 2014

N2 - Objective. To characterize the epidemiology of Sjögren's syndrome (SS), including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets, and treatment used in Japan. Methods. The Research Team for Autoimmune Diseases, the Research Program for Intractable Disease by the Ministry of Health, Labor and Welfare conducted primary and secondary surveys on epidemiology of SS in 2011. The primary survey covered 4,729 out of 14,095 Japan-wide Hospital Departments to investigate the prevalence of SS. The secondary survey encompassed 214 Hospital Departments that agreed to the survey, to characterize disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets, and treatments. Results. The number of patients with SS in Japan estimated by the primary survey was 68,483. The secondary survey involving data collected from 2,195 SS patients from 98 Hospital Departments showed that the mean age of patients was 60.8 ± 15.2 years, male/female ratio was 1/17.4, primary/secondary SS was about 60%/40% and glandular/extra-glandular form in primary SS was about 70%/25%. The satisfaction rate was 53.8% for the 1999 revised Japanese Ministry of Health criteria for the diagnosis of SS, 47.7% for the 2002 American-European Consensus Group classification criteria for SS and 49.6% for 2012 American College of Rheumatology classification criteria for SS. Corticosteroids were used by 752 of 2,195 patients (34%), immunosuppressants by 358 patients (16%), biologics by 68 patients (3%) and secretagogues by 695 patients (32%). Conclusion. The surveys provided valuable information on the epidemiology of SS including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets and treatments used today in Japan.

AB - Objective. To characterize the epidemiology of Sjögren's syndrome (SS), including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets, and treatment used in Japan. Methods. The Research Team for Autoimmune Diseases, the Research Program for Intractable Disease by the Ministry of Health, Labor and Welfare conducted primary and secondary surveys on epidemiology of SS in 2011. The primary survey covered 4,729 out of 14,095 Japan-wide Hospital Departments to investigate the prevalence of SS. The secondary survey encompassed 214 Hospital Departments that agreed to the survey, to characterize disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets, and treatments. Results. The number of patients with SS in Japan estimated by the primary survey was 68,483. The secondary survey involving data collected from 2,195 SS patients from 98 Hospital Departments showed that the mean age of patients was 60.8 ± 15.2 years, male/female ratio was 1/17.4, primary/secondary SS was about 60%/40% and glandular/extra-glandular form in primary SS was about 70%/25%. The satisfaction rate was 53.8% for the 1999 revised Japanese Ministry of Health criteria for the diagnosis of SS, 47.7% for the 2002 American-European Consensus Group classification criteria for SS and 49.6% for 2012 American College of Rheumatology classification criteria for SS. Corticosteroids were used by 752 of 2,195 patients (34%), immunosuppressants by 358 patients (16%), biologics by 68 patients (3%) and secretagogues by 695 patients (32%). Conclusion. The surveys provided valuable information on the epidemiology of SS including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets and treatments used today in Japan.

KW - Criteria

KW - Epidemiology

KW - Extra-glandular form

KW - Glandular form

KW - Sjögren's syndrome

KW - Treatment

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