Primary carcinosarcoma of the vagina

Rie Shibata, Akihiro Umezawa, Kyoko Takehara, Daisuke Aoki, Shiro Nozawa, Jun Ichi Hata

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Abstract

Primary carcinosarcoma of the vagina is a very rare tumor, with only eight cases diagnosed as carcinosarcoma in the literature that we are aware of. We recently encountered a case of primary carcinosarcoma of the vagina in a 75-year-old woman. The patient had a history of hysterectomy and bilateral ovariectomy for uterine corpus cancer at 55 years of age. Recurrence of the cancer was suspected 17 years after the operation and irradiation therapy was performed, but the patient died 3 years after the recurrence. Autopsy revealed a mass lesion in the pelvic cavity that originated in the vagina. Histological examination showed that the tumor contained anaplastic carcinoma, rhabdomyosarcoma, leiomyosarcoma and chondrosarcoma components, and it was diagnosed as carcinosarcoma. The histological diagnosis of the uterine corpus cancer was well-differentiated adenocarcinoma, and there was no sarcomatous component. The carcinosarcoma occurred 17 years after the hysterectomy, and it was concluded to be a primary carcinosarcoma of the vagina. This is the first case of primary vaginal carcinosarcoma in which the epithelial and sarcomatous components were clearly identified histologically and immunohistochemically.

Original languageEnglish
Pages (from-to)106-110
Number of pages5
JournalPathology International
Volume53
Issue number2
DOIs
Publication statusPublished - 2003 Feb 1

Fingerprint

Carcinosarcoma
Vagina
Uterine Neoplasms
Hysterectomy
Recurrence
Neoplasms
Chondrosarcoma
Leiomyosarcoma
Rhabdomyosarcoma
Ovariectomy
Autopsy
Adenocarcinoma
Carcinoma

Keywords

  • Carcinosarcoma
  • Malignant mixed mullelian tumor
  • Vagina

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Shibata, R., Umezawa, A., Takehara, K., Aoki, D., Nozawa, S., & Hata, J. I. (2003). Primary carcinosarcoma of the vagina. Pathology International, 53(2), 106-110. https://doi.org/10.1046/j.1440-1827.2003.01442.x

Primary carcinosarcoma of the vagina. / Shibata, Rie; Umezawa, Akihiro; Takehara, Kyoko; Aoki, Daisuke; Nozawa, Shiro; Hata, Jun Ichi.

In: Pathology International, Vol. 53, No. 2, 01.02.2003, p. 106-110.

Research output: Contribution to journalArticle

Shibata, R, Umezawa, A, Takehara, K, Aoki, D, Nozawa, S & Hata, JI 2003, 'Primary carcinosarcoma of the vagina', Pathology International, vol. 53, no. 2, pp. 106-110. https://doi.org/10.1046/j.1440-1827.2003.01442.x
Shibata R, Umezawa A, Takehara K, Aoki D, Nozawa S, Hata JI. Primary carcinosarcoma of the vagina. Pathology International. 2003 Feb 1;53(2):106-110. https://doi.org/10.1046/j.1440-1827.2003.01442.x
Shibata, Rie ; Umezawa, Akihiro ; Takehara, Kyoko ; Aoki, Daisuke ; Nozawa, Shiro ; Hata, Jun Ichi. / Primary carcinosarcoma of the vagina. In: Pathology International. 2003 ; Vol. 53, No. 2. pp. 106-110.
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