Primary ependymoma of the ovary, in which long-term oral etoposide (VP-16) was effective in prolonging disease-free survival

Mikio Mikami, Yuuki Komuro, Naoko Sakaiya, Chisei Tei, Takashi Kurahashi, Shinichi Komiyama, Takanori Hirose

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Background. Ovarian ependymoma is an extremely unusual teratoma of the ovary with only eight cases previously reported in the literature worldwide. Case. A 26-year-old woman presented in 1992 with a sensation of abdominal fullness. The laparotomy revealed ovarian cancer (stage III), which proved to be an ependymoma pathologically. Three courses of the PVP regimen (cisplatin, vinblastine, peplomycin) and pelvic irradiation were administered postoperatively. Oral administration of etoposide (VP-16) was initiated after the residual tumor began to proliferate, and the tumor decreased in size and never regrew during etoposide administration for a total of 5 years and 8 months. The recurrent tumor was observed soon after the drug was discontinued. Conclusion. Oral administration of etoposide was effective in prolonging disease-free survival.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalGynecologic Oncology
Volume83
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Ependymoma
  • Etoposide
  • Ovarian neoplasma
  • VP-16

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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