Primary low-grade lymphoma of mucosa-associated lymphoid tissue of the urinary bladder: A case report with special reference to the use of ancillary diagnostic studies

Ko Ando, Yoshihiro Matsuno, Yae Kanai, Michiie Sakamoto, Hiroyuki Fujimoto, Masaru Narabayashi, Ken Ichi Tobisu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We report a case of primary low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type of the urinary bladder. The patient, a 77-year-old woman, presented with a sense of urinary retention. An intravenous pyelogram and cystoscopy revealed a wide-based submucosal mass measuring 3 cm in the left wall of the urinary bladder. Histological findings of the tissue obtained by transurethral resection (TUR) showed a dense, monomorphic atypical lymphoid (centrocyte-like) infiltrate with reactive lymph follicles in the subepithelial tissue. Monocytoid and plasmacytoid features were readily evident in a population of these cells. Lymphoepithelial lesions involving the urothelium were also noticed in some areas. These features were strongly suggestive of primary low-grade lymphoma of the MALT type. The diagnosis was confirmed by immunohistochemical and flow cytometric studies, both of which showed a clear immunoglobulin restriction to lambda light chain and also by polymerase chain reaction-based assay using a formalin-fixed paraffin-embedded TUR tissue sample, which showed a clonal Ig heavy-chain gene rearrangement. Clinical staging procedures revealed that the tumor was localized in the urinary bladder. The patient has not received chemotherapy and is alive and well with no evidence of recurrence, 3 years after TUR. This case demonstrates that these ancillary tests are worth performing for confirmation of B-cell clonality in TUR tissue samples showing dense B-lymphocytic infiltration.

Original languageEnglish
Pages (from-to)636-639
Number of pages4
JournalJapanese Journal of Clinical Oncology
Volume29
Issue number12
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Marginal Zone B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Urinary Bladder
Urothelium
Immunoglobulin Heavy Chains
Cystoscopy
Urinary Retention
Gene Rearrangement
Urography
B-Cell Lymphoma
Lymph
Paraffin
Formaldehyde
Immunoglobulins
B-Lymphocytes
Light
Recurrence
Drug Therapy
Polymerase Chain Reaction
Population

Keywords

  • Flow cytometry
  • Immunohistochemistry
  • Malignant lymphoma
  • Polymerase chain reaction
  • Urinary bladder

ASJC Scopus subject areas

  • Oncology

Cite this

Primary low-grade lymphoma of mucosa-associated lymphoid tissue of the urinary bladder : A case report with special reference to the use of ancillary diagnostic studies. / Ando, Ko; Matsuno, Yoshihiro; Kanai, Yae; Sakamoto, Michiie; Fujimoto, Hiroyuki; Narabayashi, Masaru; Tobisu, Ken Ichi.

In: Japanese Journal of Clinical Oncology, Vol. 29, No. 12, 1999, p. 636-639.

Research output: Contribution to journalArticle

@article{8a58d9ae814a496a9784fc75bec61d02,
title = "Primary low-grade lymphoma of mucosa-associated lymphoid tissue of the urinary bladder: A case report with special reference to the use of ancillary diagnostic studies",
abstract = "We report a case of primary low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type of the urinary bladder. The patient, a 77-year-old woman, presented with a sense of urinary retention. An intravenous pyelogram and cystoscopy revealed a wide-based submucosal mass measuring 3 cm in the left wall of the urinary bladder. Histological findings of the tissue obtained by transurethral resection (TUR) showed a dense, monomorphic atypical lymphoid (centrocyte-like) infiltrate with reactive lymph follicles in the subepithelial tissue. Monocytoid and plasmacytoid features were readily evident in a population of these cells. Lymphoepithelial lesions involving the urothelium were also noticed in some areas. These features were strongly suggestive of primary low-grade lymphoma of the MALT type. The diagnosis was confirmed by immunohistochemical and flow cytometric studies, both of which showed a clear immunoglobulin restriction to lambda light chain and also by polymerase chain reaction-based assay using a formalin-fixed paraffin-embedded TUR tissue sample, which showed a clonal Ig heavy-chain gene rearrangement. Clinical staging procedures revealed that the tumor was localized in the urinary bladder. The patient has not received chemotherapy and is alive and well with no evidence of recurrence, 3 years after TUR. This case demonstrates that these ancillary tests are worth performing for confirmation of B-cell clonality in TUR tissue samples showing dense B-lymphocytic infiltration.",
keywords = "Flow cytometry, Immunohistochemistry, Malignant lymphoma, Polymerase chain reaction, Urinary bladder",
author = "Ko Ando and Yoshihiro Matsuno and Yae Kanai and Michiie Sakamoto and Hiroyuki Fujimoto and Masaru Narabayashi and Tobisu, {Ken Ichi}",
year = "1999",
language = "English",
volume = "29",
pages = "636--639",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Primary low-grade lymphoma of mucosa-associated lymphoid tissue of the urinary bladder

T2 - A case report with special reference to the use of ancillary diagnostic studies

AU - Ando, Ko

AU - Matsuno, Yoshihiro

AU - Kanai, Yae

AU - Sakamoto, Michiie

AU - Fujimoto, Hiroyuki

AU - Narabayashi, Masaru

AU - Tobisu, Ken Ichi

PY - 1999

Y1 - 1999

N2 - We report a case of primary low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type of the urinary bladder. The patient, a 77-year-old woman, presented with a sense of urinary retention. An intravenous pyelogram and cystoscopy revealed a wide-based submucosal mass measuring 3 cm in the left wall of the urinary bladder. Histological findings of the tissue obtained by transurethral resection (TUR) showed a dense, monomorphic atypical lymphoid (centrocyte-like) infiltrate with reactive lymph follicles in the subepithelial tissue. Monocytoid and plasmacytoid features were readily evident in a population of these cells. Lymphoepithelial lesions involving the urothelium were also noticed in some areas. These features were strongly suggestive of primary low-grade lymphoma of the MALT type. The diagnosis was confirmed by immunohistochemical and flow cytometric studies, both of which showed a clear immunoglobulin restriction to lambda light chain and also by polymerase chain reaction-based assay using a formalin-fixed paraffin-embedded TUR tissue sample, which showed a clonal Ig heavy-chain gene rearrangement. Clinical staging procedures revealed that the tumor was localized in the urinary bladder. The patient has not received chemotherapy and is alive and well with no evidence of recurrence, 3 years after TUR. This case demonstrates that these ancillary tests are worth performing for confirmation of B-cell clonality in TUR tissue samples showing dense B-lymphocytic infiltration.

AB - We report a case of primary low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type of the urinary bladder. The patient, a 77-year-old woman, presented with a sense of urinary retention. An intravenous pyelogram and cystoscopy revealed a wide-based submucosal mass measuring 3 cm in the left wall of the urinary bladder. Histological findings of the tissue obtained by transurethral resection (TUR) showed a dense, monomorphic atypical lymphoid (centrocyte-like) infiltrate with reactive lymph follicles in the subepithelial tissue. Monocytoid and plasmacytoid features were readily evident in a population of these cells. Lymphoepithelial lesions involving the urothelium were also noticed in some areas. These features were strongly suggestive of primary low-grade lymphoma of the MALT type. The diagnosis was confirmed by immunohistochemical and flow cytometric studies, both of which showed a clear immunoglobulin restriction to lambda light chain and also by polymerase chain reaction-based assay using a formalin-fixed paraffin-embedded TUR tissue sample, which showed a clonal Ig heavy-chain gene rearrangement. Clinical staging procedures revealed that the tumor was localized in the urinary bladder. The patient has not received chemotherapy and is alive and well with no evidence of recurrence, 3 years after TUR. This case demonstrates that these ancillary tests are worth performing for confirmation of B-cell clonality in TUR tissue samples showing dense B-lymphocytic infiltration.

KW - Flow cytometry

KW - Immunohistochemistry

KW - Malignant lymphoma

KW - Polymerase chain reaction

KW - Urinary bladder

UR - http://www.scopus.com/inward/record.url?scp=0033252370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033252370&partnerID=8YFLogxK

M3 - Article

C2 - 10721948

AN - SCOPUS:0033252370

VL - 29

SP - 636

EP - 639

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 12

ER -