Primary malignant hepatic pheochromocytoma with negative adrenal scintigraphy

Koichiro Homma, Koichi Hayashi, Shu Wakino, Rie Irie, Makio Mukai, Hiroo Kumagai, Hirotaka Shibata, Takao Saruta

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A 60-year-old male patient with hypertension was referred to our hospital because of insufficient blood pressure control (190/98 mmHg) and to rule out secondary hypertension. A computed tomography scan revealed no adrenal tumor but a large liver mass (5 × 5 cm), and magnetic resonance imaging showed a high signal intensity lesion on the T2-weighted image. Twenty-four hour urinary excretion of catecholamine metabolites was markedly increased, although a 123l-metaiodobenzyl guanidine (MIBG) scintigram failed to show accumulation in the hepatic mass, and no difference was noted between the catecholamine concentration in the tumor-drainage vein and that obtained from the vein draining from the non-tumor area. Liver biopsy did show features compatible with pheochromocytoma (i.e., chromogranin A-positive cells). Transcatheter arterial embolization of the liver tumor was conducted and resulted in a marked (50%) decrease in the 24-h urine normetanephrine excretion. Several metastatic foci were noted in the spinal bone and transcatheter arterial embolization (TAE) was also conducted with successful results. Thus, we experienced a case of primary malignant hepatic pheochromocytoma with negative 123l-MIBG scanning.

Original languageEnglish
Pages (from-to)551-554
Number of pages4
JournalHypertension Research
Issue number7
Publication statusPublished - 2006 Jul


  • Embolization
  • Liver
  • Metalodobenzyl guanidine
  • Metastasis
  • Pheochromocytoma

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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