Primary malignant melanoma of the uterine cervix or vagina which were successfully treated with nivolumab

Research output: Contribution to journalArticle

Abstract

Primary malignant melanomas (MM) originating from the gynecological tract are rare. They respond poorly to immunotherapy when compared with cutaneous MM. This study reports two cases. The first is of a 54-year-old woman with a cervical amelanotic polypoid mass who was diagnosed as having stage IB1 cervical melanoma according to the International Federation of Gynecology and Obstetrics system. At 17 months post-surgery, a computed tomography examination revealed recurrence of a 68 mm pelvic tumor. The second case is of a 37-year-old woman with a 7 cm hemorrhagic mass on the vaginal wall. The patient was diagnosed as having stage IV vaginal melanoma according to the American Joint Committee on Cancer definition. Both patients received nivolumab therapy, programmed cell death receptor 1 monoclonal antibodies, and the tumors almost disappeared. These cases may add the possibility of using colposcopy with narrow-band imaging and positron-emission tomography to diagnose and evaluate primary MM.

Original languageEnglish
JournalJournal of Obstetrics and Gynaecology Research
DOIs
Publication statusAccepted/In press - 2019 Jan 1

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Vagina
Melanoma
Programmed Cell Death 1 Receptor
Narrow Band Imaging
Neoplasms
Colposcopy
Gynecology
Positron-Emission Tomography
Immunotherapy
Obstetrics
Monoclonal Antibodies
Tomography
Recurrence
nivolumab
Primary malignant melanoma of the cervix
Therapeutics

Keywords

  • colposcopy
  • melanoma
  • nivolumab
  • uterine cervix
  • vagina

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

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title = "Primary malignant melanoma of the uterine cervix or vagina which were successfully treated with nivolumab",
abstract = "Primary malignant melanomas (MM) originating from the gynecological tract are rare. They respond poorly to immunotherapy when compared with cutaneous MM. This study reports two cases. The first is of a 54-year-old woman with a cervical amelanotic polypoid mass who was diagnosed as having stage IB1 cervical melanoma according to the International Federation of Gynecology and Obstetrics system. At 17 months post-surgery, a computed tomography examination revealed recurrence of a 68 mm pelvic tumor. The second case is of a 37-year-old woman with a 7 cm hemorrhagic mass on the vaginal wall. The patient was diagnosed as having stage IV vaginal melanoma according to the American Joint Committee on Cancer definition. Both patients received nivolumab therapy, programmed cell death receptor 1 monoclonal antibodies, and the tumors almost disappeared. These cases may add the possibility of using colposcopy with narrow-band imaging and positron-emission tomography to diagnose and evaluate primary MM.",
keywords = "colposcopy, melanoma, nivolumab, uterine cervix, vagina",
author = "Mayuka Anko and Masaru Nakamura and Yusuke Kobayashi and Kosuke Tsuji and Sakura Nakada and Yoshio Nakamura and Takeru Funakoshi and Kouji Banno and Daisuke Aoki",
year = "2019",
month = "1",
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doi = "10.1111/jog.14136",
language = "English",
journal = "Asia-Oceania Journal of Obstetrics and Gynaecology",
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AU - Anko, Mayuka

AU - Nakamura, Masaru

AU - Kobayashi, Yusuke

AU - Tsuji, Kosuke

AU - Nakada, Sakura

AU - Nakamura, Yoshio

AU - Funakoshi, Takeru

AU - Banno, Kouji

AU - Aoki, Daisuke

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Primary malignant melanomas (MM) originating from the gynecological tract are rare. They respond poorly to immunotherapy when compared with cutaneous MM. This study reports two cases. The first is of a 54-year-old woman with a cervical amelanotic polypoid mass who was diagnosed as having stage IB1 cervical melanoma according to the International Federation of Gynecology and Obstetrics system. At 17 months post-surgery, a computed tomography examination revealed recurrence of a 68 mm pelvic tumor. The second case is of a 37-year-old woman with a 7 cm hemorrhagic mass on the vaginal wall. The patient was diagnosed as having stage IV vaginal melanoma according to the American Joint Committee on Cancer definition. Both patients received nivolumab therapy, programmed cell death receptor 1 monoclonal antibodies, and the tumors almost disappeared. These cases may add the possibility of using colposcopy with narrow-band imaging and positron-emission tomography to diagnose and evaluate primary MM.

AB - Primary malignant melanomas (MM) originating from the gynecological tract are rare. They respond poorly to immunotherapy when compared with cutaneous MM. This study reports two cases. The first is of a 54-year-old woman with a cervical amelanotic polypoid mass who was diagnosed as having stage IB1 cervical melanoma according to the International Federation of Gynecology and Obstetrics system. At 17 months post-surgery, a computed tomography examination revealed recurrence of a 68 mm pelvic tumor. The second case is of a 37-year-old woman with a 7 cm hemorrhagic mass on the vaginal wall. The patient was diagnosed as having stage IV vaginal melanoma according to the American Joint Committee on Cancer definition. Both patients received nivolumab therapy, programmed cell death receptor 1 monoclonal antibodies, and the tumors almost disappeared. These cases may add the possibility of using colposcopy with narrow-band imaging and positron-emission tomography to diagnose and evaluate primary MM.

KW - colposcopy

KW - melanoma

KW - nivolumab

KW - uterine cervix

KW - vagina

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