Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: A project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study

Kenji Wakai, Nobuyuki Hamajima, Rieko Okada, Mariko Naito, Emi Morita, Asahi Hishida, Sayo Kawai, Kazuko Nishio, Guang Yin, Yatami Asai, Keitaro Matsuo, Satoyo Hosono, Hidemi Ito, Miki Watanabe, Takakazu Kawase, Takeshi Suzuki, Kazuo Tajima, Keitaro Tanaka, Yasuki Higaki, Megumi HaraTakeshi Imaizumi, Naoto Taguchi, Kazuyo Nakamura, Hinako Nanri, Tatsuhiko Sakamoto, Mikako Horita, Koichi Shinchi, Yoshikuni Kita, Tanvir Chowdhury Turin, Nahid Rumana, Kenji Matsui, Katsuyuki Miura, Hirotsugu Ueshima, Naoyuki Takashima, Yasuyuki Nakamura, Sadao Suzuki, Ryosuke Ando, Akihiro Hosono, Nahomi Imaeda, Kiyoshi Shibata, Chiho Goto, Nami Hattori, Mitsuru Fukatsu, Tamaki Yamada, Shinkan Tokudome, Toshiro Takezaki, Hideshi Niimura, Kazuyo Hirasada, Akihiko Nakamura, Masaya Tatebo, Shin Ogawa, Noriko Tsunematsu, Shirabe Chiba, Haruo Mikami, Suminori Kono, Keizo Ohnaka, Ryoichi Takayanagi, Yoshiyuki Watanabe, Etsuko Ozaki, Masako Shigeta, Nagato Kuriyama, Aya Yoshikawa, Daisuke Matsui, Isao Watanabe, Kaoru Inoue, Kotaro Ozasa, Satoko Mitani, Kokichi Arisawa, Hirokazu Uemura, Mineyoshi Hiyoshi, Hidenobu Takami, Miwa Yamaguchi, Mariko Nakamoto, Hideo Takeda, Michiaki Kubo, Hideo Tanaka

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene-environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005. Methods: We initiated a cross-sectional study to examine associations of genotypes with lifestyle and clinical factors, as assessed by questionnaires and medical examinations. The 4519 subjects were selected from among participants in the J-MICC Study in 10 areas throughout Japan. In total, 108 polymorphisms were chosen and genotyped using the Invader assay. Results: The study group comprised 2124 men and 2395 women with a mean age of 55.8 ± 8.9 years (range, 35-69 years) at baseline. Among the 108 polymorphisms examined, 4 were not polymorphic in our study population. Among the remaining 104 polymorphisms, most variations were common (minor allele frequency ≥0.05 for 96 polymorphisms). The allele frequencies in this population were comparable with those in the HapMap-JPT data set for 45 Japanese from Tokyo. Only 5 of 88 polymorphisms showed allele-frequency differences greater than 0.1. Of the 108 polymorphisms, 32 showed a highly significant difference in minor allele frequency among the study areas (P < 0.001). Conclusions: This comprehensive data collection on lifestyle and clinical factors will be useful for elucidating gene-environment interactions. In addition, it is likely to be an informative reference tool, as free access to genotype data for a large Japanese population is not readily available.

Original languageEnglish
Pages (from-to)223-235
Number of pages13
JournalJournal of epidemiology
Volume21
Issue number3
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Allele Frequency
  • Cross-Sectional Studies
  • Gene-Environment Interactions
  • Japan Multi-Institutional Collaborative Cohort Study
  • Polymorphism

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: A project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study'. Together they form a unique fingerprint.

Cite this