Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors

A project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study

Kenji Wakai, Nobuyuki Hamajima, Rieko Okada, Mariko Naito, Emi Morita, Asahi Hishida, Sayo Kawai, Kazuko Nishio, Guang Yin, Yatami Asai, Keitaro Matsuo, Satoyo Hosono, Hidemi Ito, Miki Watanabe, Takakazu Kawase, Takeshi Suzuki, Kazuo Tajima, Keitaro Tanaka, Yasuki Higaki, Megumi Hara & 56 others Takeshi Imaizumi, Naoto Taguchi, Kazuyo Nakamura, Hinako Nanri, Tatsuhiko Sakamoto, Mikako Horita, Koichi Shinchi, Yoshikuni Kita, Tanvir Chowdhury Turin, Nahid Rumana, Kenji Matsui, Katsuyuki Miura, Hirotsugu Ueshima, Naoyuki Takashima, Yasuyuki Nakamura, Sadao Suzuki, Ryosuke Ando, Akihiro Hosono, Nahomi Imaeda, Kiyoshi Shibata, Chiho Goto, Nami Hattori, Mitsuru Fukatsu, Tamaki Yamada, Shinkan Tokudome, Toshiro Takezaki, Hideshi Niimura, Kazuyo Kuwabara, Akihiko Nakamura, Masaya Tatebo, Shin Ogawa, Noriko Tsunematsu, Shirabe Chiba, Haruo Mikami, Suminori Kono, Keizo Ohnaka, Ryoichi Takayanagi, Yoshiyuki Watanabe, Etsuko Ozaki, Masako Shigeta, Nagato Kuriyama, Aya Yoshikawa, Daisuke Matsui, Isao Watanabe, Kaoru Inoue, Kotaro Ozasa, Satoko Mitani, Kokichi Arisawa, Hirokazu Uemura, Mineyoshi Hiyoshi, Hidenobu Takami, Miwa Yamaguchi, Mariko Nakamoto, Hideo Takeda, Michiaki Kubo, Hideo Tanaka

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene-environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005. Methods: We initiated a cross-sectional study to examine associations of genotypes with lifestyle and clinical factors, as assessed by questionnaires and medical examinations. The 4519 subjects were selected from among participants in the J-MICC Study in 10 areas throughout Japan. In total, 108 polymorphisms were chosen and genotyped using the Invader assay. Results: The study group comprised 2124 men and 2395 women with a mean age of 55.8 ± 8.9 years (range, 35-69 years) at baseline. Among the 108 polymorphisms examined, 4 were not polymorphic in our study population. Among the remaining 104 polymorphisms, most variations were common (minor allele frequency ≥0.05 for 96 polymorphisms). The allele frequencies in this population were comparable with those in the HapMap-JPT data set for 45 Japanese from Tokyo. Only 5 of 88 polymorphisms showed allele-frequency differences greater than 0.1. Of the 108 polymorphisms, 32 showed a highly significant difference in minor allele frequency among the study areas (P < 0.001). Conclusions: This comprehensive data collection on lifestyle and clinical factors will be useful for elucidating gene-environment interactions. In addition, it is likely to be an informative reference tool, as free access to genotype data for a large Japanese population is not readily available.

Original languageEnglish
Pages (from-to)223-235
Number of pages13
JournalJournal of Epidemiology
Volume21
Issue number3
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Gene Frequency
Life Style
Japan
Cohort Studies
Cross-Sectional Studies
Genotype
Gene-Environment Interaction
HapMap Project
Population
Tokyo
Neoplasms

Keywords

  • Allele Frequency
  • Cross-Sectional Studies
  • Gene-Environment Interactions
  • Japan Multi-Institutional Collaborative Cohort Study
  • Polymorphism

ASJC Scopus subject areas

  • Epidemiology

Cite this

Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors : A project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. / Wakai, Kenji; Hamajima, Nobuyuki; Okada, Rieko; Naito, Mariko; Morita, Emi; Hishida, Asahi; Kawai, Sayo; Nishio, Kazuko; Yin, Guang; Asai, Yatami; Matsuo, Keitaro; Hosono, Satoyo; Ito, Hidemi; Watanabe, Miki; Kawase, Takakazu; Suzuki, Takeshi; Tajima, Kazuo; Tanaka, Keitaro; Higaki, Yasuki; Hara, Megumi; Imaizumi, Takeshi; Taguchi, Naoto; Nakamura, Kazuyo; Nanri, Hinako; Sakamoto, Tatsuhiko; Horita, Mikako; Shinchi, Koichi; Kita, Yoshikuni; Turin, Tanvir Chowdhury; Rumana, Nahid; Matsui, Kenji; Miura, Katsuyuki; Ueshima, Hirotsugu; Takashima, Naoyuki; Nakamura, Yasuyuki; Suzuki, Sadao; Ando, Ryosuke; Hosono, Akihiro; Imaeda, Nahomi; Shibata, Kiyoshi; Goto, Chiho; Hattori, Nami; Fukatsu, Mitsuru; Yamada, Tamaki; Tokudome, Shinkan; Takezaki, Toshiro; Niimura, Hideshi; Kuwabara, Kazuyo; Nakamura, Akihiko; Tatebo, Masaya; Ogawa, Shin; Tsunematsu, Noriko; Chiba, Shirabe; Mikami, Haruo; Kono, Suminori; Ohnaka, Keizo; Takayanagi, Ryoichi; Watanabe, Yoshiyuki; Ozaki, Etsuko; Shigeta, Masako; Kuriyama, Nagato; Yoshikawa, Aya; Matsui, Daisuke; Watanabe, Isao; Inoue, Kaoru; Ozasa, Kotaro; Mitani, Satoko; Arisawa, Kokichi; Uemura, Hirokazu; Hiyoshi, Mineyoshi; Takami, Hidenobu; Yamaguchi, Miwa; Nakamoto, Mariko; Takeda, Hideo; Kubo, Michiaki; Tanaka, Hideo.

In: Journal of Epidemiology, Vol. 21, No. 3, 2011, p. 223-235.

Research output: Contribution to journalArticle

Wakai, K, Hamajima, N, Okada, R, Naito, M, Morita, E, Hishida, A, Kawai, S, Nishio, K, Yin, G, Asai, Y, Matsuo, K, Hosono, S, Ito, H, Watanabe, M, Kawase, T, Suzuki, T, Tajima, K, Tanaka, K, Higaki, Y, Hara, M, Imaizumi, T, Taguchi, N, Nakamura, K, Nanri, H, Sakamoto, T, Horita, M, Shinchi, K, Kita, Y, Turin, TC, Rumana, N, Matsui, K, Miura, K, Ueshima, H, Takashima, N, Nakamura, Y, Suzuki, S, Ando, R, Hosono, A, Imaeda, N, Shibata, K, Goto, C, Hattori, N, Fukatsu, M, Yamada, T, Tokudome, S, Takezaki, T, Niimura, H, Kuwabara, K, Nakamura, A, Tatebo, M, Ogawa, S, Tsunematsu, N, Chiba, S, Mikami, H, Kono, S, Ohnaka, K, Takayanagi, R, Watanabe, Y, Ozaki, E, Shigeta, M, Kuriyama, N, Yoshikawa, A, Matsui, D, Watanabe, I, Inoue, K, Ozasa, K, Mitani, S, Arisawa, K, Uemura, H, Hiyoshi, M, Takami, H, Yamaguchi, M, Nakamoto, M, Takeda, H, Kubo, M & Tanaka, H 2011, 'Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: A project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study', Journal of Epidemiology, vol. 21, no. 3, pp. 223-235. https://doi.org/10.2188/jea.JE20100139
Wakai, Kenji ; Hamajima, Nobuyuki ; Okada, Rieko ; Naito, Mariko ; Morita, Emi ; Hishida, Asahi ; Kawai, Sayo ; Nishio, Kazuko ; Yin, Guang ; Asai, Yatami ; Matsuo, Keitaro ; Hosono, Satoyo ; Ito, Hidemi ; Watanabe, Miki ; Kawase, Takakazu ; Suzuki, Takeshi ; Tajima, Kazuo ; Tanaka, Keitaro ; Higaki, Yasuki ; Hara, Megumi ; Imaizumi, Takeshi ; Taguchi, Naoto ; Nakamura, Kazuyo ; Nanri, Hinako ; Sakamoto, Tatsuhiko ; Horita, Mikako ; Shinchi, Koichi ; Kita, Yoshikuni ; Turin, Tanvir Chowdhury ; Rumana, Nahid ; Matsui, Kenji ; Miura, Katsuyuki ; Ueshima, Hirotsugu ; Takashima, Naoyuki ; Nakamura, Yasuyuki ; Suzuki, Sadao ; Ando, Ryosuke ; Hosono, Akihiro ; Imaeda, Nahomi ; Shibata, Kiyoshi ; Goto, Chiho ; Hattori, Nami ; Fukatsu, Mitsuru ; Yamada, Tamaki ; Tokudome, Shinkan ; Takezaki, Toshiro ; Niimura, Hideshi ; Kuwabara, Kazuyo ; Nakamura, Akihiko ; Tatebo, Masaya ; Ogawa, Shin ; Tsunematsu, Noriko ; Chiba, Shirabe ; Mikami, Haruo ; Kono, Suminori ; Ohnaka, Keizo ; Takayanagi, Ryoichi ; Watanabe, Yoshiyuki ; Ozaki, Etsuko ; Shigeta, Masako ; Kuriyama, Nagato ; Yoshikawa, Aya ; Matsui, Daisuke ; Watanabe, Isao ; Inoue, Kaoru ; Ozasa, Kotaro ; Mitani, Satoko ; Arisawa, Kokichi ; Uemura, Hirokazu ; Hiyoshi, Mineyoshi ; Takami, Hidenobu ; Yamaguchi, Miwa ; Nakamoto, Mariko ; Takeda, Hideo ; Kubo, Michiaki ; Tanaka, Hideo. / Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors : A project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. In: Journal of Epidemiology. 2011 ; Vol. 21, No. 3. pp. 223-235.
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TY - JOUR

T1 - Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors

T2 - A project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study

AU - Wakai, Kenji

AU - Hamajima, Nobuyuki

AU - Okada, Rieko

AU - Naito, Mariko

AU - Morita, Emi

AU - Hishida, Asahi

AU - Kawai, Sayo

AU - Nishio, Kazuko

AU - Yin, Guang

AU - Asai, Yatami

AU - Matsuo, Keitaro

AU - Hosono, Satoyo

AU - Ito, Hidemi

AU - Watanabe, Miki

AU - Kawase, Takakazu

AU - Suzuki, Takeshi

AU - Tajima, Kazuo

AU - Tanaka, Keitaro

AU - Higaki, Yasuki

AU - Hara, Megumi

AU - Imaizumi, Takeshi

AU - Taguchi, Naoto

AU - Nakamura, Kazuyo

AU - Nanri, Hinako

AU - Sakamoto, Tatsuhiko

AU - Horita, Mikako

AU - Shinchi, Koichi

AU - Kita, Yoshikuni

AU - Turin, Tanvir Chowdhury

AU - Rumana, Nahid

AU - Matsui, Kenji

AU - Miura, Katsuyuki

AU - Ueshima, Hirotsugu

AU - Takashima, Naoyuki

AU - Nakamura, Yasuyuki

AU - Suzuki, Sadao

AU - Ando, Ryosuke

AU - Hosono, Akihiro

AU - Imaeda, Nahomi

AU - Shibata, Kiyoshi

AU - Goto, Chiho

AU - Hattori, Nami

AU - Fukatsu, Mitsuru

AU - Yamada, Tamaki

AU - Tokudome, Shinkan

AU - Takezaki, Toshiro

AU - Niimura, Hideshi

AU - Kuwabara, Kazuyo

AU - Nakamura, Akihiko

AU - Tatebo, Masaya

AU - Ogawa, Shin

AU - Tsunematsu, Noriko

AU - Chiba, Shirabe

AU - Mikami, Haruo

AU - Kono, Suminori

AU - Ohnaka, Keizo

AU - Takayanagi, Ryoichi

AU - Watanabe, Yoshiyuki

AU - Ozaki, Etsuko

AU - Shigeta, Masako

AU - Kuriyama, Nagato

AU - Yoshikawa, Aya

AU - Matsui, Daisuke

AU - Watanabe, Isao

AU - Inoue, Kaoru

AU - Ozasa, Kotaro

AU - Mitani, Satoko

AU - Arisawa, Kokichi

AU - Uemura, Hirokazu

AU - Hiyoshi, Mineyoshi

AU - Takami, Hidenobu

AU - Yamaguchi, Miwa

AU - Nakamoto, Mariko

AU - Takeda, Hideo

AU - Kubo, Michiaki

AU - Tanaka, Hideo

PY - 2011

Y1 - 2011

N2 - Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene-environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005. Methods: We initiated a cross-sectional study to examine associations of genotypes with lifestyle and clinical factors, as assessed by questionnaires and medical examinations. The 4519 subjects were selected from among participants in the J-MICC Study in 10 areas throughout Japan. In total, 108 polymorphisms were chosen and genotyped using the Invader assay. Results: The study group comprised 2124 men and 2395 women with a mean age of 55.8 ± 8.9 years (range, 35-69 years) at baseline. Among the 108 polymorphisms examined, 4 were not polymorphic in our study population. Among the remaining 104 polymorphisms, most variations were common (minor allele frequency ≥0.05 for 96 polymorphisms). The allele frequencies in this population were comparable with those in the HapMap-JPT data set for 45 Japanese from Tokyo. Only 5 of 88 polymorphisms showed allele-frequency differences greater than 0.1. Of the 108 polymorphisms, 32 showed a highly significant difference in minor allele frequency among the study areas (P < 0.001). Conclusions: This comprehensive data collection on lifestyle and clinical factors will be useful for elucidating gene-environment interactions. In addition, it is likely to be an informative reference tool, as free access to genotype data for a large Japanese population is not readily available.

AB - Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene-environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005. Methods: We initiated a cross-sectional study to examine associations of genotypes with lifestyle and clinical factors, as assessed by questionnaires and medical examinations. The 4519 subjects were selected from among participants in the J-MICC Study in 10 areas throughout Japan. In total, 108 polymorphisms were chosen and genotyped using the Invader assay. Results: The study group comprised 2124 men and 2395 women with a mean age of 55.8 ± 8.9 years (range, 35-69 years) at baseline. Among the 108 polymorphisms examined, 4 were not polymorphic in our study population. Among the remaining 104 polymorphisms, most variations were common (minor allele frequency ≥0.05 for 96 polymorphisms). The allele frequencies in this population were comparable with those in the HapMap-JPT data set for 45 Japanese from Tokyo. Only 5 of 88 polymorphisms showed allele-frequency differences greater than 0.1. Of the 108 polymorphisms, 32 showed a highly significant difference in minor allele frequency among the study areas (P < 0.001). Conclusions: This comprehensive data collection on lifestyle and clinical factors will be useful for elucidating gene-environment interactions. In addition, it is likely to be an informative reference tool, as free access to genotype data for a large Japanese population is not readily available.

KW - Allele Frequency

KW - Cross-Sectional Studies

KW - Gene-Environment Interactions

KW - Japan Multi-Institutional Collaborative Cohort Study

KW - Polymorphism

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