Prognosis of primary aldosteronism in japan: Results from a nationwide epidemiological study

Yoshihiro Miyake, Keiko Tanaka, Tetsuo Nishikawa, Mitsuhide Naruse, Ryoichi Takayanagi, Hironobu Sasano, Yoshiyu Takeda, Hirotaka Shibata, Masakatsu Sone, Fumitoshi Satoh, Masanobu Yamada, Hajime Ueshiba, Takuyuki Katabami, Yasumasa Iwasaki, Hirotoshi Tanaka, Yusuke Tanahashi, Shigeru Suzuki, Tomonobu Hasegawa, Noriyuki Katsumata, Toshihiro TajimaToshihiko Yanase

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Abstract

The Research Committee of Disorders of Adrenal Hormones, Japan, undertook a nationwide epidemiological study of primary aldosteronism (PA). The present study was undertaken as a part of this study to reveal the relationship between type of treatment and the prognosis of PA. In the primary survey, 4161 patients with PA during the period January 1, 2003-December 31, 2007 were reported from 3252 departments of internal medicine, pediatrics and urology. In the secondary survey, a questionnaire that requested detailed clinical information on individual patients was sent to those departments reporting patients in the primary survey. In total, data on 1706 patients with PA were available in the present study. Among patients with bilateral or unilateral aldosterone-producing adenoma, after adjustment for age at which prognosis was examined, sex, surgical treatment and medical treatment, surgical treatment was significantly associated with amelioration of hypertension (adjusted odds ratio [OR]: 0.47 [95% confidence interval (CI): 0.29-0.77]) and hypokalemia (adjusted OR: 0.17 [95% CI: 0.11-0.29]). No significant relationship was observed between medical treatment and such prognosis in this group of patients. Among patients with bilateral or unilateral adrenal hyperplasia, surgical, but not medical, treatment was significantly associated with amelioration of hypokalemia (adjusted OR: 0.23 [95% CI: 0.06-0.74]), while there was no relationship between surgical or medical treatment and the prognosis of hypertension. In conclusion, surgery offered a better prognosis of PA than medication with regards to hypertension and hypokalemia, with the limitation that a new anti-aldosterone drug, eplerenone, was not available during the study period.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalEndocrine journal
Volume61
Issue number1
DOIs
Publication statusPublished - 2014 Feb 5

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Keywords

  • Medical treatment
  • Nationwide epidemiological study
  • Primary aldosteronism
  • Prognosis
  • Surgical treatment

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Miyake, Y., Tanaka, K., Nishikawa, T., Naruse, M., Takayanagi, R., Sasano, H., Takeda, Y., Shibata, H., Sone, M., Satoh, F., Yamada, M., Ueshiba, H., Katabami, T., Iwasaki, Y., Tanaka, H., Tanahashi, Y., Suzuki, S., Hasegawa, T., Katsumata, N., ... Yanase, T. (2014). Prognosis of primary aldosteronism in japan: Results from a nationwide epidemiological study. Endocrine journal, 61(1), 35-40. https://doi.org/10.1507/endocrj.EJ13-0353