Prognostic factors and treatment outcomes of 100 cases of anaplastic thyroid carcinoma

Junko Akaishi, Kiminori Sugino, Wataru Kitagawa, Mitsuji Nagahama, Kaori Kameyama, Kazuo Shimizu, Kunihiko Ito, Koichi Ito

Research output: Contribution to journalArticle

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Abstract

Background: Anaplastic thyroid carcinoma (ATC) is a malignancy with one of the highest fatality rates. Here we report a retrospective study of the treatment and other factors associated with its outcomes. Materials and Methods: The medical records of 100 patients diagnosed with ATC at Ito Hospital between 1993 and 2009 were reviewed and pertinent information was extracted and analyzed. Results: There were 80 women and 20 men, and their median age at diagnosis was 68 years (range, 41-90 years). Thirteen patients had a history of well-differentiated thyroid carcinoma. Six patients had a small ATC focus within a differentiated carcinoma. All cases were retrospectively staged according to the Union for International Cancer Control classification system, and the results were stage IVA in 11 cases, stage IVB in 31 cases, and stage IVC in 58 cases. Seventy patients underwent surgical treatment, and complete resection was performed in 24 of them. Seventy-eight patients received radiotherapy, and 58 of them received a total dose of ≥40 Gy. Twenty-seven patients received chemotherapy. Only 15 patients received multimodal therapy (surgery, radiotherapy, and chemotherapy). The 1-year survival rates according to stage were as follows: stage IVA, 72.7%; stage IVB, 24.8%; and stage IVC, 8.2%. Multivariate analysis identified age ≥70 years, white blood cell ≥10,000 mm 3, extrathyroidal invasion, and distant metastasis at the time of diagnosis as prognostic factors. Survival after complete resection was significantly better than after incomplete resection or no resection. The results also suggested that radiation doses of ≥40 Gy were associated with significantly longer survival. Conclusion: Although the prognosis of most patients with ATC continues to be poor, surgery, radiotherapy, and a combination of both improved the survival of patients with ATC.

Original languageEnglish
Pages (from-to)1183-1189
Number of pages7
JournalThyroid
Volume21
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

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Radiotherapy
Survival
Anaplastic Thyroid Carcinoma
Drug Therapy
Thyroid Neoplasms
Medical Records
Neoplasms
Leukocytes
Therapeutics
Multivariate Analysis
Survival Rate
Retrospective Studies
Radiation
Neoplasm Metastasis
Carcinoma

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Akaishi, J., Sugino, K., Kitagawa, W., Nagahama, M., Kameyama, K., Shimizu, K., ... Ito, K. (2011). Prognostic factors and treatment outcomes of 100 cases of anaplastic thyroid carcinoma. Thyroid, 21(11), 1183-1189. https://doi.org/10.1089/thy.2010.0332

Prognostic factors and treatment outcomes of 100 cases of anaplastic thyroid carcinoma. / Akaishi, Junko; Sugino, Kiminori; Kitagawa, Wataru; Nagahama, Mitsuji; Kameyama, Kaori; Shimizu, Kazuo; Ito, Kunihiko; Ito, Koichi.

In: Thyroid, Vol. 21, No. 11, 01.11.2011, p. 1183-1189.

Research output: Contribution to journalArticle

Akaishi, J, Sugino, K, Kitagawa, W, Nagahama, M, Kameyama, K, Shimizu, K, Ito, K & Ito, K 2011, 'Prognostic factors and treatment outcomes of 100 cases of anaplastic thyroid carcinoma', Thyroid, vol. 21, no. 11, pp. 1183-1189. https://doi.org/10.1089/thy.2010.0332
Akaishi J, Sugino K, Kitagawa W, Nagahama M, Kameyama K, Shimizu K et al. Prognostic factors and treatment outcomes of 100 cases of anaplastic thyroid carcinoma. Thyroid. 2011 Nov 1;21(11):1183-1189. https://doi.org/10.1089/thy.2010.0332
Akaishi, Junko ; Sugino, Kiminori ; Kitagawa, Wataru ; Nagahama, Mitsuji ; Kameyama, Kaori ; Shimizu, Kazuo ; Ito, Kunihiko ; Ito, Koichi. / Prognostic factors and treatment outcomes of 100 cases of anaplastic thyroid carcinoma. In: Thyroid. 2011 ; Vol. 21, No. 11. pp. 1183-1189.
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AB - Background: Anaplastic thyroid carcinoma (ATC) is a malignancy with one of the highest fatality rates. Here we report a retrospective study of the treatment and other factors associated with its outcomes. Materials and Methods: The medical records of 100 patients diagnosed with ATC at Ito Hospital between 1993 and 2009 were reviewed and pertinent information was extracted and analyzed. Results: There were 80 women and 20 men, and their median age at diagnosis was 68 years (range, 41-90 years). Thirteen patients had a history of well-differentiated thyroid carcinoma. Six patients had a small ATC focus within a differentiated carcinoma. All cases were retrospectively staged according to the Union for International Cancer Control classification system, and the results were stage IVA in 11 cases, stage IVB in 31 cases, and stage IVC in 58 cases. Seventy patients underwent surgical treatment, and complete resection was performed in 24 of them. Seventy-eight patients received radiotherapy, and 58 of them received a total dose of ≥40 Gy. Twenty-seven patients received chemotherapy. Only 15 patients received multimodal therapy (surgery, radiotherapy, and chemotherapy). The 1-year survival rates according to stage were as follows: stage IVA, 72.7%; stage IVB, 24.8%; and stage IVC, 8.2%. Multivariate analysis identified age ≥70 years, white blood cell ≥10,000 mm 3, extrathyroidal invasion, and distant metastasis at the time of diagnosis as prognostic factors. Survival after complete resection was significantly better than after incomplete resection or no resection. The results also suggested that radiation doses of ≥40 Gy were associated with significantly longer survival. Conclusion: Although the prognosis of most patients with ATC continues to be poor, surgery, radiotherapy, and a combination of both improved the survival of patients with ATC.

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