Prognostic factors for adult single cord blood transplantation among European and Japanese populations: the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study

Junya Kanda, Hiromi Hayashi, Annalisa Ruggeri, Fumihiko Kimura, Fernanda Volt, Satoshi Takahashi, Myriam Labopin, Shinichi Kako, Karina Tozatto-Maio, Shingo Yano, Guillermo Sanz, Naoyuki Uchida, Maria Teresa Van Lint, Seiko Kato, Mohamad Mohty, Edouard Forcade, Heiwa Kanamori, Jorge Sierra, Yuju Ohno, Riccardo SaccardiTakahiro Fukuda, Tatsuo Ichinohe, Minoko Takanashi, Vanderson Rocha, Shinichiro Okamoto, Arnon Nagler, Yoshiko Atsuta, Eliane Gluckman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Large differences in patient and transplant backgrounds make it difficult to identify consistent prognostic factors of unrelated cord blood transplantation (UCBT) among different populations. Thus, we performed a collaborative study between Eurocord/ALWP-EBMT and JSHCT/JDCHCT. Adults with acute leukaemia who underwent a single UCBT were eligible. In total, 3764 and 1027 patients of the JSHCT/JDCHCT and Eurocord/ALWP-EBMT registries, respectively, were included. The median ages of the Japanese and European cohorts were 51 and 38 years, respectively. Three or more HLA mismatches were more frequently observed in the Japanese cohort. The median total nucleated cell (TNC) counts were 2.58 and 3.51 × 107/kg in the Japanese and European cohorts, respectively. Anti-thymocyte globulin was used in only 2% of the Japanese cohort compared with 65% of the European cohort. The 3-year overall survival (OS) was 41% in JSHCT/JDCHCT and 33% in Eurocord/ALWP-EBMT. In the multivariate analysis, TNC dose and HLA matching had no significant effect on OS in either cohort, whereas year of transplantation, age, and refined disease risk index affected OS in both cohorts. Despite considerable differences in characteristics between the Japanese and European cohorts, we observed similar prognostic factors affecting UCBT outcomes in adult patients with acute leukaemia in both registries.

Original languageEnglish
JournalLeukemia
DOIs
Publication statusAccepted/In press - 2019 Jan 1

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Fetal Blood
Transplantation
Population
Survival
Registries
Leukemia
Antilymphocyte Serum
Multivariate Analysis
Cell Count
Transplants

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Prognostic factors for adult single cord blood transplantation among European and Japanese populations : the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study. / Kanda, Junya; Hayashi, Hiromi; Ruggeri, Annalisa; Kimura, Fumihiko; Volt, Fernanda; Takahashi, Satoshi; Labopin, Myriam; Kako, Shinichi; Tozatto-Maio, Karina; Yano, Shingo; Sanz, Guillermo; Uchida, Naoyuki; Van Lint, Maria Teresa; Kato, Seiko; Mohty, Mohamad; Forcade, Edouard; Kanamori, Heiwa; Sierra, Jorge; Ohno, Yuju; Saccardi, Riccardo; Fukuda, Takahiro; Ichinohe, Tatsuo; Takanashi, Minoko; Rocha, Vanderson; Okamoto, Shinichiro; Nagler, Arnon; Atsuta, Yoshiko; Gluckman, Eliane.

In: Leukemia, 01.01.2019.

Research output: Contribution to journalArticle

Kanda, J, Hayashi, H, Ruggeri, A, Kimura, F, Volt, F, Takahashi, S, Labopin, M, Kako, S, Tozatto-Maio, K, Yano, S, Sanz, G, Uchida, N, Van Lint, MT, Kato, S, Mohty, M, Forcade, E, Kanamori, H, Sierra, J, Ohno, Y, Saccardi, R, Fukuda, T, Ichinohe, T, Takanashi, M, Rocha, V, Okamoto, S, Nagler, A, Atsuta, Y & Gluckman, E 2019, 'Prognostic factors for adult single cord blood transplantation among European and Japanese populations: the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study', Leukemia. https://doi.org/10.1038/s41375-019-0534-5
Kanda, Junya ; Hayashi, Hiromi ; Ruggeri, Annalisa ; Kimura, Fumihiko ; Volt, Fernanda ; Takahashi, Satoshi ; Labopin, Myriam ; Kako, Shinichi ; Tozatto-Maio, Karina ; Yano, Shingo ; Sanz, Guillermo ; Uchida, Naoyuki ; Van Lint, Maria Teresa ; Kato, Seiko ; Mohty, Mohamad ; Forcade, Edouard ; Kanamori, Heiwa ; Sierra, Jorge ; Ohno, Yuju ; Saccardi, Riccardo ; Fukuda, Takahiro ; Ichinohe, Tatsuo ; Takanashi, Minoko ; Rocha, Vanderson ; Okamoto, Shinichiro ; Nagler, Arnon ; Atsuta, Yoshiko ; Gluckman, Eliane. / Prognostic factors for adult single cord blood transplantation among European and Japanese populations : the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study. In: Leukemia. 2019.
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abstract = "Large differences in patient and transplant backgrounds make it difficult to identify consistent prognostic factors of unrelated cord blood transplantation (UCBT) among different populations. Thus, we performed a collaborative study between Eurocord/ALWP-EBMT and JSHCT/JDCHCT. Adults with acute leukaemia who underwent a single UCBT were eligible. In total, 3764 and 1027 patients of the JSHCT/JDCHCT and Eurocord/ALWP-EBMT registries, respectively, were included. The median ages of the Japanese and European cohorts were 51 and 38 years, respectively. Three or more HLA mismatches were more frequently observed in the Japanese cohort. The median total nucleated cell (TNC) counts were 2.58 and 3.51 × 107/kg in the Japanese and European cohorts, respectively. Anti-thymocyte globulin was used in only 2{\%} of the Japanese cohort compared with 65{\%} of the European cohort. The 3-year overall survival (OS) was 41{\%} in JSHCT/JDCHCT and 33{\%} in Eurocord/ALWP-EBMT. In the multivariate analysis, TNC dose and HLA matching had no significant effect on OS in either cohort, whereas year of transplantation, age, and refined disease risk index affected OS in both cohorts. Despite considerable differences in characteristics between the Japanese and European cohorts, we observed similar prognostic factors affecting UCBT outcomes in adult patients with acute leukaemia in both registries.",
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T1 - Prognostic factors for adult single cord blood transplantation among European and Japanese populations

T2 - the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study

AU - Kanda, Junya

AU - Hayashi, Hiromi

AU - Ruggeri, Annalisa

AU - Kimura, Fumihiko

AU - Volt, Fernanda

AU - Takahashi, Satoshi

AU - Labopin, Myriam

AU - Kako, Shinichi

AU - Tozatto-Maio, Karina

AU - Yano, Shingo

AU - Sanz, Guillermo

AU - Uchida, Naoyuki

AU - Van Lint, Maria Teresa

AU - Kato, Seiko

AU - Mohty, Mohamad

AU - Forcade, Edouard

AU - Kanamori, Heiwa

AU - Sierra, Jorge

AU - Ohno, Yuju

AU - Saccardi, Riccardo

AU - Fukuda, Takahiro

AU - Ichinohe, Tatsuo

AU - Takanashi, Minoko

AU - Rocha, Vanderson

AU - Okamoto, Shinichiro

AU - Nagler, Arnon

AU - Atsuta, Yoshiko

AU - Gluckman, Eliane

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Large differences in patient and transplant backgrounds make it difficult to identify consistent prognostic factors of unrelated cord blood transplantation (UCBT) among different populations. Thus, we performed a collaborative study between Eurocord/ALWP-EBMT and JSHCT/JDCHCT. Adults with acute leukaemia who underwent a single UCBT were eligible. In total, 3764 and 1027 patients of the JSHCT/JDCHCT and Eurocord/ALWP-EBMT registries, respectively, were included. The median ages of the Japanese and European cohorts were 51 and 38 years, respectively. Three or more HLA mismatches were more frequently observed in the Japanese cohort. The median total nucleated cell (TNC) counts were 2.58 and 3.51 × 107/kg in the Japanese and European cohorts, respectively. Anti-thymocyte globulin was used in only 2% of the Japanese cohort compared with 65% of the European cohort. The 3-year overall survival (OS) was 41% in JSHCT/JDCHCT and 33% in Eurocord/ALWP-EBMT. In the multivariate analysis, TNC dose and HLA matching had no significant effect on OS in either cohort, whereas year of transplantation, age, and refined disease risk index affected OS in both cohorts. Despite considerable differences in characteristics between the Japanese and European cohorts, we observed similar prognostic factors affecting UCBT outcomes in adult patients with acute leukaemia in both registries.

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