Prognostic factors for surgically resected N2 non-small cell lung cancer

Keishi Kawasaki, Yasunori Sato, Yoshio Suzuki, Haruhisa Saito, Yukihiro Nomura, Yukihiro Yoshida

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Non-small cell lung cancers (NSCLCs) with pathologically documented ipsilateral mediastinal lymph node (LN) metastases (pN2) are a broad spectrum of diseases. We retrospectively analyzed prognostic factors for cases of pN2 NSCLC treated by surgical resection. Methods: Clinicopathological data were reviewed for consecutive 121 patients who underwent anatomical pulmonary resection with mediastinal LN sampling or dissection for pN2 NSCLC over a 15-year period. Results: The 5-year survival rate for all patients was 29.9%. Clinical N status, curability, surgical procedure and adjuvant chemotherapy were favorable prognostic factors in uni-variate analysis, with 5-year survival rates of 35.0% for cN0/1 vs. 17.7% for cN2/3 cases; 33.1% for R0 vs. 14.7% for R1/2 resection; 31.5% for lobectomy vs. 25.0% for bilobectomy and 15.6% for pneumonectomy; and 72.7% with adjuvant chemotherapy vs. 23.8% without adjuvant chemotherapy. Survival did not differ significantly based on gender, age, smoking status, clinical T status, tumor location, histology, skip metastasis, subcarinal LN metastasis, or number of involved N2 levels. In multivariate analysis, adjuvant chemotherapy, R0 resection, and lobectomy emerged as independent favorable prognostic factors. Conclusion: Complete resection using lobectomy and adjuvant chemotherapy are favorable prognostic factors in cases of pN2 NSCLC.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalAnnals of Thoracic and Cardiovascular Surgery
Volume21
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

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Adjuvant Chemotherapy
Non-Small Cell Lung Carcinoma
Lymph Nodes
Neoplasm Metastasis
Survival Rate
Pneumonectomy
Dissection
Histology
Multivariate Analysis
Smoking
Lung
Survival
Neoplasms

Keywords

  • Carcinoma Non-Small-Cell Lung
  • Lymph Nodes
  • Survival Analysis
  • Thoracic Surgery

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Gastroenterology

Cite this

Prognostic factors for surgically resected N2 non-small cell lung cancer. / Kawasaki, Keishi; Sato, Yasunori; Suzuki, Yoshio; Saito, Haruhisa; Nomura, Yukihiro; Yoshida, Yukihiro.

In: Annals of Thoracic and Cardiovascular Surgery, Vol. 21, No. 3, 01.01.2015, p. 217-222.

Research output: Contribution to journalArticle

Kawasaki, K, Sato, Y, Suzuki, Y, Saito, H, Nomura, Y & Yoshida, Y 2015, 'Prognostic factors for surgically resected N2 non-small cell lung cancer', Annals of Thoracic and Cardiovascular Surgery, vol. 21, no. 3, pp. 217-222. https://doi.org/10.5761/atcs.oa.14-00218
Kawasaki, Keishi ; Sato, Yasunori ; Suzuki, Yoshio ; Saito, Haruhisa ; Nomura, Yukihiro ; Yoshida, Yukihiro. / Prognostic factors for surgically resected N2 non-small cell lung cancer. In: Annals of Thoracic and Cardiovascular Surgery. 2015 ; Vol. 21, No. 3. pp. 217-222.
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