Prognostic factors or indicators of gynecologic cancers

Shiro Nozawa, Daisuke Aoki, Kaneyuki Kubushiro, Nobuyuki Susumu, Koji Banno, Yutaka Tamada

Research output: Contribution to journalReview article

Abstract

The large majority of gynecologic malignancies are comprised of cervical cancer, endometrial cancer and ovarian cancer. Prognostic factors for each disease are based upon various clinical pathological features. These include tumor size and lymph node metastasis for cervical cancer; histological grade, myometrial invasion, and lymph node metastasis for endometrial cancer; histopathological classification, histological grade, and capsule rupture in early ovarian cancer and completeness of debulking surgery in advanced ovarian cancer. In addition to these factors, recent studies have investigated the role of various molecules including growth factors, virus-related molecules, transcription factors, receptors-ligands, cell cycle-related molecules, apoptosis-related molecules as well as various genetic abnormalities as prognostic factors or indicators for gynecologic malignancies. This molecular background of gynecologic cancers will shape future directions in the increasingly individualized basis of treatment.

Original languageEnglish
Pages (from-to)263-271
Number of pages9
JournalBiotherapy
Volume19
Issue number3
Publication statusPublished - 2005 May 1

Keywords

  • Cervical cancer
  • Endometrial cancer
  • Ovarian cancer
  • Prognostic factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Nozawa, S., Aoki, D., Kubushiro, K., Susumu, N., Banno, K., & Tamada, Y. (2005). Prognostic factors or indicators of gynecologic cancers. Biotherapy, 19(3), 263-271.