Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma: Possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment

Shunki Hirayama, Genichiro Ishii, Kanji Nagai, Shotaro Ono, Motohiro Kojima, Chisako Yamauchi, Keiju Aokage, Tomoyuki Hishida, Junji Yoshida, Kenji Suzuki, Atsushi Ochiai

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

INTRODUCTION:: Tumor-associated macrophages (TAMs) are recruited into cancer-induced stroma and produce a specific microenvironment for cancer progression. CD204 (+) TAMs are reportedly related to tumor progression and clinical outcome in some tumors. The aim of this study was to clarify the correlation between CD204 (+) TAMs and the clinicopathological features of lung squamous cell carcinoma. METHODS:: We investigated the relationships between the numbers of CD204 (+) TAMs and clinicopathological factors, microvessel density, and the numbers of Foxp3 (+) lymphocytes in 208 consecutively resected cases. We also examined the relationships between the numbers of CD204 (+) TAMs and the expression levels of cytokines involved in the migration and differentiation of CD204 (+) TAMs. RESULTS:: A high number of CD204 (+) TAMs in the stroma was significantly correlated with an advanced p-stage, T factor, N factor, and the presence of vascular and pleural invasion. A high number of CD204 (+) TAMs in the stroma was also a significant prognostic factor for all p-stages and p-stage I. Moreover, the numbers of CD204 (+) TAMs were correlated with the microvessel density and the numbers of Foxp3 (+) lymphocytes. A high number of CD204 (+) TAMs was strongly correlated with the tissue expression level of monocyte chemoattractant protein-1. CD204 (+) TAMs were shown to be significant independent prognostic factors in a multivariate analysis. CONCLUSIONS:: CD204 (+) TAMs were an independent prognostic factor in lung squamous cell carcinoma. CD204 (+) TAMs, along with other tumor-promoting stromal cells such as regulatory T cells and endothelial cells, may create tumor-promoting microenvironments.

Original languageEnglish
Pages (from-to)1790-1797
Number of pages8
JournalJournal of Thoracic Oncology
Volume7
Issue number12
DOIs
Publication statusPublished - 2012 Dec
Externally publishedYes

Fingerprint

Tumor Microenvironment
Squamous Cell Carcinoma
Macrophages
Lung
Neoplasms
Lymphocyte Count
Microvessels
Chemokine CCL2
Regulatory T-Lymphocytes
Stromal Cells

Keywords

  • CD204
  • Non-smallcell lung carcinoma
  • Squamous cell carcinoma
  • Tumor associated macrophages

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma : Possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment. / Hirayama, Shunki; Ishii, Genichiro; Nagai, Kanji; Ono, Shotaro; Kojima, Motohiro; Yamauchi, Chisako; Aokage, Keiju; Hishida, Tomoyuki; Yoshida, Junji; Suzuki, Kenji; Ochiai, Atsushi.

In: Journal of Thoracic Oncology, Vol. 7, No. 12, 12.2012, p. 1790-1797.

Research output: Contribution to journalArticle

Hirayama, Shunki ; Ishii, Genichiro ; Nagai, Kanji ; Ono, Shotaro ; Kojima, Motohiro ; Yamauchi, Chisako ; Aokage, Keiju ; Hishida, Tomoyuki ; Yoshida, Junji ; Suzuki, Kenji ; Ochiai, Atsushi. / Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma : Possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment. In: Journal of Thoracic Oncology. 2012 ; Vol. 7, No. 12. pp. 1790-1797.
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T1 - Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma

T2 - Possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment

AU - Hirayama, Shunki

AU - Ishii, Genichiro

AU - Nagai, Kanji

AU - Ono, Shotaro

AU - Kojima, Motohiro

AU - Yamauchi, Chisako

AU - Aokage, Keiju

AU - Hishida, Tomoyuki

AU - Yoshida, Junji

AU - Suzuki, Kenji

AU - Ochiai, Atsushi

PY - 2012/12

Y1 - 2012/12

N2 - INTRODUCTION:: Tumor-associated macrophages (TAMs) are recruited into cancer-induced stroma and produce a specific microenvironment for cancer progression. CD204 (+) TAMs are reportedly related to tumor progression and clinical outcome in some tumors. The aim of this study was to clarify the correlation between CD204 (+) TAMs and the clinicopathological features of lung squamous cell carcinoma. METHODS:: We investigated the relationships between the numbers of CD204 (+) TAMs and clinicopathological factors, microvessel density, and the numbers of Foxp3 (+) lymphocytes in 208 consecutively resected cases. We also examined the relationships between the numbers of CD204 (+) TAMs and the expression levels of cytokines involved in the migration and differentiation of CD204 (+) TAMs. RESULTS:: A high number of CD204 (+) TAMs in the stroma was significantly correlated with an advanced p-stage, T factor, N factor, and the presence of vascular and pleural invasion. A high number of CD204 (+) TAMs in the stroma was also a significant prognostic factor for all p-stages and p-stage I. Moreover, the numbers of CD204 (+) TAMs were correlated with the microvessel density and the numbers of Foxp3 (+) lymphocytes. A high number of CD204 (+) TAMs was strongly correlated with the tissue expression level of monocyte chemoattractant protein-1. CD204 (+) TAMs were shown to be significant independent prognostic factors in a multivariate analysis. CONCLUSIONS:: CD204 (+) TAMs were an independent prognostic factor in lung squamous cell carcinoma. CD204 (+) TAMs, along with other tumor-promoting stromal cells such as regulatory T cells and endothelial cells, may create tumor-promoting microenvironments.

AB - INTRODUCTION:: Tumor-associated macrophages (TAMs) are recruited into cancer-induced stroma and produce a specific microenvironment for cancer progression. CD204 (+) TAMs are reportedly related to tumor progression and clinical outcome in some tumors. The aim of this study was to clarify the correlation between CD204 (+) TAMs and the clinicopathological features of lung squamous cell carcinoma. METHODS:: We investigated the relationships between the numbers of CD204 (+) TAMs and clinicopathological factors, microvessel density, and the numbers of Foxp3 (+) lymphocytes in 208 consecutively resected cases. We also examined the relationships between the numbers of CD204 (+) TAMs and the expression levels of cytokines involved in the migration and differentiation of CD204 (+) TAMs. RESULTS:: A high number of CD204 (+) TAMs in the stroma was significantly correlated with an advanced p-stage, T factor, N factor, and the presence of vascular and pleural invasion. A high number of CD204 (+) TAMs in the stroma was also a significant prognostic factor for all p-stages and p-stage I. Moreover, the numbers of CD204 (+) TAMs were correlated with the microvessel density and the numbers of Foxp3 (+) lymphocytes. A high number of CD204 (+) TAMs was strongly correlated with the tissue expression level of monocyte chemoattractant protein-1. CD204 (+) TAMs were shown to be significant independent prognostic factors in a multivariate analysis. CONCLUSIONS:: CD204 (+) TAMs were an independent prognostic factor in lung squamous cell carcinoma. CD204 (+) TAMs, along with other tumor-promoting stromal cells such as regulatory T cells and endothelial cells, may create tumor-promoting microenvironments.

KW - CD204

KW - Non-smallcell lung carcinoma

KW - Squamous cell carcinoma

KW - Tumor associated macrophages

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