Prognostic impact of intratumoral vascular invasion in non-small cell lung cancer patients

Ryo Maeda, Junji Yoshida, Genichiro Ishii, Tomoyuki Hishida, Mitsuyo Nishimura, Kanji Nagai

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: Intratumoral vascular invasion (IVI) in patients with non-small cell lung cancer (NSCLC) has been reported to be a strong independent predictor of recurrence, but it has not been incorporated in the TNM classifications including the latest 7th edition. The purpose of this study was to evaluate its significance as a risk factor for recurrence. Methods: Between July 1992 and December 2006, 2295 consecutive patients with pathological T1-4N0-2 NSCLC underwent complete resection with systematic lymph node dissection at the National Cancer Center Hospital East. The recurrence-free proportion was estimated using the Kaplan-Meier method and differences were determined by the log rank test. Cox proportional hazard ratios were used to identify independent risk factors for recurrence. Results: The proportion of recurrence-free patients at 5 years was 85.0% for patients without IVI and 51.5% for patients with IVI (p<0.001). On multivariate analyses, IVI proved to be an independently statistically significant risk factor for recurrence (HR 1.866, p<0.001). The recurrencefree proportion of patients with IVI was significantly lower than for patients without IVI in T1a (93.1% vs 69.3%, p<0.001), T1b (89.7% vs 62.7%, p<0.001), T2a (78.4%vs 53.0%, p<0.001), T2b (70.5% vs 46.4%, p=0.021) and T3 (53.1% vs 37.4%, p=0.031) subgroups. Conclusions In resected patients with T1-4N0-2 NSCLC, IVI was an independently significant risk factor for recurrence. IVI should be examined and its data collected to be considered for the next revision of the TNM staging system.

Original languageEnglish
Pages (from-to)1092-1098
Number of pages7
JournalThorax
Volume65
Issue number12
DOIs
Publication statusPublished - 2010 Dec
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Blood Vessels
Recurrence
Neoplasm Staging
Cancer Care Facilities
Lymph Node Excision
Multivariate Analysis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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Prognostic impact of intratumoral vascular invasion in non-small cell lung cancer patients. / Maeda, Ryo; Yoshida, Junji; Ishii, Genichiro; Hishida, Tomoyuki; Nishimura, Mitsuyo; Nagai, Kanji.

In: Thorax, Vol. 65, No. 12, 12.2010, p. 1092-1098.

Research output: Contribution to journalArticle

Maeda, R, Yoshida, J, Ishii, G, Hishida, T, Nishimura, M & Nagai, K 2010, 'Prognostic impact of intratumoral vascular invasion in non-small cell lung cancer patients', Thorax, vol. 65, no. 12, pp. 1092-1098. https://doi.org/10.1136/thx.2010.141861
Maeda, Ryo ; Yoshida, Junji ; Ishii, Genichiro ; Hishida, Tomoyuki ; Nishimura, Mitsuyo ; Nagai, Kanji. / Prognostic impact of intratumoral vascular invasion in non-small cell lung cancer patients. In: Thorax. 2010 ; Vol. 65, No. 12. pp. 1092-1098.
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abstract = "Objective: Intratumoral vascular invasion (IVI) in patients with non-small cell lung cancer (NSCLC) has been reported to be a strong independent predictor of recurrence, but it has not been incorporated in the TNM classifications including the latest 7th edition. The purpose of this study was to evaluate its significance as a risk factor for recurrence. Methods: Between July 1992 and December 2006, 2295 consecutive patients with pathological T1-4N0-2 NSCLC underwent complete resection with systematic lymph node dissection at the National Cancer Center Hospital East. The recurrence-free proportion was estimated using the Kaplan-Meier method and differences were determined by the log rank test. Cox proportional hazard ratios were used to identify independent risk factors for recurrence. Results: The proportion of recurrence-free patients at 5 years was 85.0{\%} for patients without IVI and 51.5{\%} for patients with IVI (p<0.001). On multivariate analyses, IVI proved to be an independently statistically significant risk factor for recurrence (HR 1.866, p<0.001). The recurrencefree proportion of patients with IVI was significantly lower than for patients without IVI in T1a (93.1{\%} vs 69.3{\%}, p<0.001), T1b (89.7{\%} vs 62.7{\%}, p<0.001), T2a (78.4{\%}vs 53.0{\%}, p<0.001), T2b (70.5{\%} vs 46.4{\%}, p=0.021) and T3 (53.1{\%} vs 37.4{\%}, p=0.031) subgroups. Conclusions In resected patients with T1-4N0-2 NSCLC, IVI was an independently significant risk factor for recurrence. IVI should be examined and its data collected to be considered for the next revision of the TNM staging system.",
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AU - Maeda, Ryo

AU - Yoshida, Junji

AU - Ishii, Genichiro

AU - Hishida, Tomoyuki

AU - Nishimura, Mitsuyo

AU - Nagai, Kanji

PY - 2010/12

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N2 - Objective: Intratumoral vascular invasion (IVI) in patients with non-small cell lung cancer (NSCLC) has been reported to be a strong independent predictor of recurrence, but it has not been incorporated in the TNM classifications including the latest 7th edition. The purpose of this study was to evaluate its significance as a risk factor for recurrence. Methods: Between July 1992 and December 2006, 2295 consecutive patients with pathological T1-4N0-2 NSCLC underwent complete resection with systematic lymph node dissection at the National Cancer Center Hospital East. The recurrence-free proportion was estimated using the Kaplan-Meier method and differences were determined by the log rank test. Cox proportional hazard ratios were used to identify independent risk factors for recurrence. Results: The proportion of recurrence-free patients at 5 years was 85.0% for patients without IVI and 51.5% for patients with IVI (p<0.001). On multivariate analyses, IVI proved to be an independently statistically significant risk factor for recurrence (HR 1.866, p<0.001). The recurrencefree proportion of patients with IVI was significantly lower than for patients without IVI in T1a (93.1% vs 69.3%, p<0.001), T1b (89.7% vs 62.7%, p<0.001), T2a (78.4%vs 53.0%, p<0.001), T2b (70.5% vs 46.4%, p=0.021) and T3 (53.1% vs 37.4%, p=0.031) subgroups. Conclusions In resected patients with T1-4N0-2 NSCLC, IVI was an independently significant risk factor for recurrence. IVI should be examined and its data collected to be considered for the next revision of the TNM staging system.

AB - Objective: Intratumoral vascular invasion (IVI) in patients with non-small cell lung cancer (NSCLC) has been reported to be a strong independent predictor of recurrence, but it has not been incorporated in the TNM classifications including the latest 7th edition. The purpose of this study was to evaluate its significance as a risk factor for recurrence. Methods: Between July 1992 and December 2006, 2295 consecutive patients with pathological T1-4N0-2 NSCLC underwent complete resection with systematic lymph node dissection at the National Cancer Center Hospital East. The recurrence-free proportion was estimated using the Kaplan-Meier method and differences were determined by the log rank test. Cox proportional hazard ratios were used to identify independent risk factors for recurrence. Results: The proportion of recurrence-free patients at 5 years was 85.0% for patients without IVI and 51.5% for patients with IVI (p<0.001). On multivariate analyses, IVI proved to be an independently statistically significant risk factor for recurrence (HR 1.866, p<0.001). The recurrencefree proportion of patients with IVI was significantly lower than for patients without IVI in T1a (93.1% vs 69.3%, p<0.001), T1b (89.7% vs 62.7%, p<0.001), T2a (78.4%vs 53.0%, p<0.001), T2b (70.5% vs 46.4%, p=0.021) and T3 (53.1% vs 37.4%, p=0.031) subgroups. Conclusions In resected patients with T1-4N0-2 NSCLC, IVI was an independently significant risk factor for recurrence. IVI should be examined and its data collected to be considered for the next revision of the TNM staging system.

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