Abstract
Introduction: We previously showed that squamous cell carcinoma (SCC) patients with directly involved N1 nodes resulted in outcomes significantly better than those with separately involved N1 nodes. The purpose of this study was to evaluate the prognostic effect of node involvement patterns in pN1 non-small cell lung cancer (NSCLC) patients, with special attention given to any differences between SCC and adenocarcinoma (AD). Methods: We reviewed 324 consecutive patients with completely resected pN1 NSCLC and classified them into two groups based on their node involvement patterns: directly or separately involved N1 groups. To compare survival rates, 1545 pN0 patients and 330 pN2 patients were also investigated. Results: Univariate and multivariate analyses showed that the node involvement pattern was significantly associated with pN1 NSCLC patient outcome. The directly involved N1 group had a much better 5-year overall survival rate of 60.1% compared with 45.0% for the separately involved N1 group. In SCC patients, the directly involved N1 group showed an overall survival similar to pN0 patients, whereas overall survival of the separately involved N1 group was identical to that of pN2 patients, and their survival rates were significantly different. In AD patients, however, the survival rates were marginally different between the directly and separately involved N1 groups, and they were intermediate between pN0 and pN2 patient survival rates. Conclusions: Node involvement patterns had significant prognostic effect in pN1 NSCLC patients. This effect was different between SCC and AD cases. The subclassification of N1 based on node involvement pattern is of significance for SCC patients but not for AD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1576-1582 |
| Number of pages | 7 |
| Journal | Journal of Thoracic Oncology |
| Volume | 5 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2010 Oct |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Oncology
- Pulmonary and Respiratory Medicine
Cite this
Prognostic impact of node involvement pattern in pN1 non-small cell lung cancer patients. / Nakao, Masayuki; Yoshida, Junji; Ishii, Genichiro; Kawase, Akikazu; Maeda, Ryo; Aokage, Keiju; Hishida, Tomoyuki; Nishimura, Mitsuyo; Nagai, Kanji.
In: Journal of Thoracic Oncology, Vol. 5, No. 10, 10.2010, p. 1576-1582.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic impact of node involvement pattern in pN1 non-small cell lung cancer patients
AU - Nakao, Masayuki
AU - Yoshida, Junji
AU - Ishii, Genichiro
AU - Kawase, Akikazu
AU - Maeda, Ryo
AU - Aokage, Keiju
AU - Hishida, Tomoyuki
AU - Nishimura, Mitsuyo
AU - Nagai, Kanji
PY - 2010/10
Y1 - 2010/10
N2 - Introduction: We previously showed that squamous cell carcinoma (SCC) patients with directly involved N1 nodes resulted in outcomes significantly better than those with separately involved N1 nodes. The purpose of this study was to evaluate the prognostic effect of node involvement patterns in pN1 non-small cell lung cancer (NSCLC) patients, with special attention given to any differences between SCC and adenocarcinoma (AD). Methods: We reviewed 324 consecutive patients with completely resected pN1 NSCLC and classified them into two groups based on their node involvement patterns: directly or separately involved N1 groups. To compare survival rates, 1545 pN0 patients and 330 pN2 patients were also investigated. Results: Univariate and multivariate analyses showed that the node involvement pattern was significantly associated with pN1 NSCLC patient outcome. The directly involved N1 group had a much better 5-year overall survival rate of 60.1% compared with 45.0% for the separately involved N1 group. In SCC patients, the directly involved N1 group showed an overall survival similar to pN0 patients, whereas overall survival of the separately involved N1 group was identical to that of pN2 patients, and their survival rates were significantly different. In AD patients, however, the survival rates were marginally different between the directly and separately involved N1 groups, and they were intermediate between pN0 and pN2 patient survival rates. Conclusions: Node involvement patterns had significant prognostic effect in pN1 NSCLC patients. This effect was different between SCC and AD cases. The subclassification of N1 based on node involvement pattern is of significance for SCC patients but not for AD patients.
AB - Introduction: We previously showed that squamous cell carcinoma (SCC) patients with directly involved N1 nodes resulted in outcomes significantly better than those with separately involved N1 nodes. The purpose of this study was to evaluate the prognostic effect of node involvement patterns in pN1 non-small cell lung cancer (NSCLC) patients, with special attention given to any differences between SCC and adenocarcinoma (AD). Methods: We reviewed 324 consecutive patients with completely resected pN1 NSCLC and classified them into two groups based on their node involvement patterns: directly or separately involved N1 groups. To compare survival rates, 1545 pN0 patients and 330 pN2 patients were also investigated. Results: Univariate and multivariate analyses showed that the node involvement pattern was significantly associated with pN1 NSCLC patient outcome. The directly involved N1 group had a much better 5-year overall survival rate of 60.1% compared with 45.0% for the separately involved N1 group. In SCC patients, the directly involved N1 group showed an overall survival similar to pN0 patients, whereas overall survival of the separately involved N1 group was identical to that of pN2 patients, and their survival rates were significantly different. In AD patients, however, the survival rates were marginally different between the directly and separately involved N1 groups, and they were intermediate between pN0 and pN2 patient survival rates. Conclusions: Node involvement patterns had significant prognostic effect in pN1 NSCLC patients. This effect was different between SCC and AD cases. The subclassification of N1 based on node involvement pattern is of significance for SCC patients but not for AD patients.
UR - http://www.scopus.com/inward/record.url?scp=77958190659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958190659&partnerID=8YFLogxK
U2 - 10.1097/JTO.0b013e3181ec7e70
DO - 10.1097/JTO.0b013e3181ec7e70
M3 - Article
C2 - 20802346
AN - SCOPUS:77958190659
VL - 5
SP - 1576
EP - 1582
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
SN - 1556-0864
IS - 10
ER -