Prognostic impact of pleural invasion in 1488 patients with surgically resected non-small cell lung carcinoma

Mayumi Oyama, Akiko Miyagi Maeshima, Naobumi Tochigi, Koji Tsuta, Riken Kawachi, Hiroyuki Sakurai, Shunichi Watanabe, Hisao Asamura, Hitoshi Tsuda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: This study aimed to verify the prognostic impact of pleural invasion according to the revised TNM classification, seventh edition. Methods: The study consisted of 1488 patients with surgically resected non-small cell carcinoma. The degree (pl0-3) and location of pleural invasion were examined using hematoxylin and eosin- and elastica van Gieson-stained slides, and outcome was compared with stratification by several clinicopathological factors. Results: The 5-year overall survival rates of 1008, 260, 85 and 135 patients with pl0, pl1, pl2 and pl3 tumours were 80, 60, 55 and 52%, respectively. Overall survival differed significantly between patients with pl0 tumours and those with pl1 tumours (P< 0.0001). The difference was significant for patients with 1 <≤ 2 cm (P = 0.004), 2,<≤ 3 cm (P = 0.003) and 3,<≤ 5 cm (P = 0.02) tumours. The overall survival of pl0 patients was also significantly better in patients with adenocarcinoma (P< 0.0001) than squamous cell carcinoma (P = 0.043). The overall survival of pl0 patients was significantly better in patients without lymph node metastasis (P< 0.0001) than in those with lymph node metastasis. The 5-year overall survival rates of patients with interlobar, lateral, mediastinal and diaphragmatic pl3 tumours were 65, 51, 51 and 40%, respectively. Overall survival did not differ significantly among these four groups. Conclusions: Outcome differs between patients with pl0 tumours and those with pl1-3 tumours, particularly among patients with 1 <≤ 2 cm, 2 <≤ 3 cm and 3<≤ 5 cm tumours, adenocarcinoma histology and no lymph node metastasis. The location of pl3 pleural invasion did not affect outcome significantly.

Original languageEnglish
Pages (from-to)540-546
Number of pages7
JournalJapanese Journal of Clinical Oncology
Volume43
Issue number5
DOIs
Publication statusPublished - 2013 May
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Neoplasms
Survival
Lymph Nodes
Neoplasm Metastasis
Adenocarcinoma
Survival Rate
Neoplasm Staging
Rubber
Hematoxylin
Eosine Yellowish-(YS)
Squamous Cell Carcinoma
Histology
Carcinoma

Keywords

  • Lung
  • Non-small cell carcinoma
  • Pleural invasion
  • TNM classification

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Prognostic impact of pleural invasion in 1488 patients with surgically resected non-small cell lung carcinoma. / Oyama, Mayumi; Maeshima, Akiko Miyagi; Tochigi, Naobumi; Tsuta, Koji; Kawachi, Riken; Sakurai, Hiroyuki; Watanabe, Shunichi; Asamura, Hisao; Tsuda, Hitoshi.

In: Japanese Journal of Clinical Oncology, Vol. 43, No. 5, 05.2013, p. 540-546.

Research output: Contribution to journalArticle

Oyama, M, Maeshima, AM, Tochigi, N, Tsuta, K, Kawachi, R, Sakurai, H, Watanabe, S, Asamura, H & Tsuda, H 2013, 'Prognostic impact of pleural invasion in 1488 patients with surgically resected non-small cell lung carcinoma', Japanese Journal of Clinical Oncology, vol. 43, no. 5, pp. 540-546. https://doi.org/10.1093/jjco/hyt039
Oyama, Mayumi ; Maeshima, Akiko Miyagi ; Tochigi, Naobumi ; Tsuta, Koji ; Kawachi, Riken ; Sakurai, Hiroyuki ; Watanabe, Shunichi ; Asamura, Hisao ; Tsuda, Hitoshi. / Prognostic impact of pleural invasion in 1488 patients with surgically resected non-small cell lung carcinoma. In: Japanese Journal of Clinical Oncology. 2013 ; Vol. 43, No. 5. pp. 540-546.
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T1 - Prognostic impact of pleural invasion in 1488 patients with surgically resected non-small cell lung carcinoma

AU - Oyama, Mayumi

AU - Maeshima, Akiko Miyagi

AU - Tochigi, Naobumi

AU - Tsuta, Koji

AU - Kawachi, Riken

AU - Sakurai, Hiroyuki

AU - Watanabe, Shunichi

AU - Asamura, Hisao

AU - Tsuda, Hitoshi

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N2 - Objective: This study aimed to verify the prognostic impact of pleural invasion according to the revised TNM classification, seventh edition. Methods: The study consisted of 1488 patients with surgically resected non-small cell carcinoma. The degree (pl0-3) and location of pleural invasion were examined using hematoxylin and eosin- and elastica van Gieson-stained slides, and outcome was compared with stratification by several clinicopathological factors. Results: The 5-year overall survival rates of 1008, 260, 85 and 135 patients with pl0, pl1, pl2 and pl3 tumours were 80, 60, 55 and 52%, respectively. Overall survival differed significantly between patients with pl0 tumours and those with pl1 tumours (P< 0.0001). The difference was significant for patients with 1 <≤ 2 cm (P = 0.004), 2,<≤ 3 cm (P = 0.003) and 3,<≤ 5 cm (P = 0.02) tumours. The overall survival of pl0 patients was also significantly better in patients with adenocarcinoma (P< 0.0001) than squamous cell carcinoma (P = 0.043). The overall survival of pl0 patients was significantly better in patients without lymph node metastasis (P< 0.0001) than in those with lymph node metastasis. The 5-year overall survival rates of patients with interlobar, lateral, mediastinal and diaphragmatic pl3 tumours were 65, 51, 51 and 40%, respectively. Overall survival did not differ significantly among these four groups. Conclusions: Outcome differs between patients with pl0 tumours and those with pl1-3 tumours, particularly among patients with 1 <≤ 2 cm, 2 <≤ 3 cm and 3<≤ 5 cm tumours, adenocarcinoma histology and no lymph node metastasis. The location of pl3 pleural invasion did not affect outcome significantly.

AB - Objective: This study aimed to verify the prognostic impact of pleural invasion according to the revised TNM classification, seventh edition. Methods: The study consisted of 1488 patients with surgically resected non-small cell carcinoma. The degree (pl0-3) and location of pleural invasion were examined using hematoxylin and eosin- and elastica van Gieson-stained slides, and outcome was compared with stratification by several clinicopathological factors. Results: The 5-year overall survival rates of 1008, 260, 85 and 135 patients with pl0, pl1, pl2 and pl3 tumours were 80, 60, 55 and 52%, respectively. Overall survival differed significantly between patients with pl0 tumours and those with pl1 tumours (P< 0.0001). The difference was significant for patients with 1 <≤ 2 cm (P = 0.004), 2,<≤ 3 cm (P = 0.003) and 3,<≤ 5 cm (P = 0.02) tumours. The overall survival of pl0 patients was also significantly better in patients with adenocarcinoma (P< 0.0001) than squamous cell carcinoma (P = 0.043). The overall survival of pl0 patients was significantly better in patients without lymph node metastasis (P< 0.0001) than in those with lymph node metastasis. The 5-year overall survival rates of patients with interlobar, lateral, mediastinal and diaphragmatic pl3 tumours were 65, 51, 51 and 40%, respectively. Overall survival did not differ significantly among these four groups. Conclusions: Outcome differs between patients with pl0 tumours and those with pl1-3 tumours, particularly among patients with 1 <≤ 2 cm, 2 <≤ 3 cm and 3<≤ 5 cm tumours, adenocarcinoma histology and no lymph node metastasis. The location of pl3 pleural invasion did not affect outcome significantly.

KW - Lung

KW - Non-small cell carcinoma

KW - Pleural invasion

KW - TNM classification

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