TY - JOUR
T1 - Prognostic impact of previous hospitalization in acute heart failure patients
AU - West Tokyo Heart Failure Registry Investigators
AU - Akita, Keitaro
AU - Kohno, Takashi
AU - Kohsaka, Shun
AU - Shiraishi, Yasuyuki
AU - Nagatomo, Yuji
AU - Goda, Ayumi
AU - Mizuno, Atsushi
AU - Sujino, Yasumori
AU - Fukuda, Keiichi
AU - Yoshikawa, Tsutomu
N1 - Funding Information:
This study was supported by Grant-in-Aid for Young Scientists (JPSS KAKENHI, 18K15860 [Y. Shiraishi]), Grant-in-Aid for Scientific Research (23591062, 26461088 [T.Y.], 17K09526 [T.K.]), Health Labour Sciences Research Grant (14528506 [S.K.]), the Sakakibara Clinical Research Grant for Promotion of Sciences (2012, 2013, 2014 [T.Y.]), and Grant from the Japan Agency for Medical Research and Development (201439013C [S.K.]).
Publisher Copyright:
© 2019, Japanese Circulation Society. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Background: The natural course of heart failure (HF) is typically associated with repeated hospitalizations, and subsequently, patient prognosis deteriorates. However, the precise relationship between repeated admissions for HF and long-term prognosis remains unknown. Methods and Results: We analyzed data from 1,730 consecutive acute HF patients registered in the West Tokyo Heart Failure (WET-HF) registry between June 2005 and April 2014 (median age, 76 years). Patients were divided into 3 groups according to the number of previous HF admissions at the time of the index admission (0, n=876 [55.4%]; 1, n=425 [26.9%]; ≥2, n=279 [17.7%] previous admissions). A history of multiple previous admissions was an independent predictor for all-cause death and HF readmission in reference to a history of a single previous admission (hazard ratio (HR), 1.53; 95% confidence interval (CI) 1.10–2.13; HR, 1.90 95% CI, 1.47–2.44, respectively) or no previous admissions (HR, 1.37, 95% CI, 1.01–1.85; HR, 2.83, 95% CI, 2.19–3.65, respec-tively). On the other hand, a history of a single previous admission was an independent predictor for HF readmission in reference to a history of no previous admissions (HR, 1.51, 95% CI, 1.18–1.92), but not for all-cause death (HR, 0.89, 95% CI, 0.66–1.20). Conclusions: Based on a contemporary multicenter HF registry, a history of multiple previous HF admissions was revealed as an independent, strong risk factor of adverse events following the index admission. The number of hospitalizations could be a simple and important surrogate indicating subsequent adverse events in patients with HF.
AB - Background: The natural course of heart failure (HF) is typically associated with repeated hospitalizations, and subsequently, patient prognosis deteriorates. However, the precise relationship between repeated admissions for HF and long-term prognosis remains unknown. Methods and Results: We analyzed data from 1,730 consecutive acute HF patients registered in the West Tokyo Heart Failure (WET-HF) registry between June 2005 and April 2014 (median age, 76 years). Patients were divided into 3 groups according to the number of previous HF admissions at the time of the index admission (0, n=876 [55.4%]; 1, n=425 [26.9%]; ≥2, n=279 [17.7%] previous admissions). A history of multiple previous admissions was an independent predictor for all-cause death and HF readmission in reference to a history of a single previous admission (hazard ratio (HR), 1.53; 95% confidence interval (CI) 1.10–2.13; HR, 1.90 95% CI, 1.47–2.44, respectively) or no previous admissions (HR, 1.37, 95% CI, 1.01–1.85; HR, 2.83, 95% CI, 2.19–3.65, respec-tively). On the other hand, a history of a single previous admission was an independent predictor for HF readmission in reference to a history of no previous admissions (HR, 1.51, 95% CI, 1.18–1.92), but not for all-cause death (HR, 0.89, 95% CI, 0.66–1.20). Conclusions: Based on a contemporary multicenter HF registry, a history of multiple previous HF admissions was revealed as an independent, strong risk factor of adverse events following the index admission. The number of hospitalizations could be a simple and important surrogate indicating subsequent adverse events in patients with HF.
KW - Heart failure
KW - Hospitalization
KW - Prognosis
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U2 - 10.1253/circj.CJ-18-1087
DO - 10.1253/circj.CJ-18-1087
M3 - Article
C2 - 30944274
AN - SCOPUS:85066496642
VL - 83
SP - 1261
EP - 1268
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 6
ER -