Prognostic implication of histological oligodendroglial tumor component: Clinicopathological analysis of 111 cases of malignant gliomas

Hiromi Kanno, Hiroshi Nishihara, Takuhito Narita, Shigeru Yamaguchi, Hiroyuki Kobayashi, Mishie Tanino, Taichi Kimura, Shunsuke Terasaka, Shinya Tanaka

Research output: Contribution to journalArticle

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Abstract

The favorable prognosis of high-grade oligodendroglial tumor such as glioblastoma (GBM) with oligodendroglioma component (GBMO) has been suggested; however, the studies which examine the prognostic significance of oligodendroglial tumor were limited. In this study, we performed a histopathology-based reevaluation of 111 cases of high grade gliomas according to the latest World Health Organization (WHO), and compared the clinical outcomes between oligodendroglial tumors and pure astrocytic tumors. The survival analysis revealed that the patients with high grade oligodendroglial tumor including GBMO significantly indicated better prognosis compared to the patients with high grade pure astrocytic tumors (GBM and AA, anaplastic astrocytoma) as expected, and the obtained survival curves were almost identical to those from the patients with conventional Grade III or Grade IV tumors, respectively. Moreover, if the cases of oligodendroglial tumor were histopathologically excluded, the patients with AA exhibited extremely poor prognosis which was similar to that of GBM, suggesting that the histological identification of oligodendroglial tumor component, even partially, prescribe the prognosis of high grade glioma patients. This is the prominent report of retrospective clinicopathological analysis for high-grade gliomas throughout Grade III and IV, especially referring to the prognostic value of histological oligodendroglial tumor component; in addition, our results might offer an alternative aspect for the grading of high-grade astrocytic/oligodendroglial tumors.

Original languageEnglish
Article numbere41669
JournalPloS one
Volume7
Issue number7
DOIs
Publication statusPublished - 2012 Jul 24
Externally publishedYes

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Glioma
Tumors
neoplasms
Neoplasms
prognosis
Glioblastoma
Oligodendroglioma
Astrocytoma
World Health Organization
Survival Analysis
histopathology
Health
Survival

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Prognostic implication of histological oligodendroglial tumor component : Clinicopathological analysis of 111 cases of malignant gliomas. / Kanno, Hiromi; Nishihara, Hiroshi; Narita, Takuhito; Yamaguchi, Shigeru; Kobayashi, Hiroyuki; Tanino, Mishie; Kimura, Taichi; Terasaka, Shunsuke; Tanaka, Shinya.

In: PloS one, Vol. 7, No. 7, e41669, 24.07.2012.

Research output: Contribution to journalArticle

Kanno, Hiromi ; Nishihara, Hiroshi ; Narita, Takuhito ; Yamaguchi, Shigeru ; Kobayashi, Hiroyuki ; Tanino, Mishie ; Kimura, Taichi ; Terasaka, Shunsuke ; Tanaka, Shinya. / Prognostic implication of histological oligodendroglial tumor component : Clinicopathological analysis of 111 cases of malignant gliomas. In: PloS one. 2012 ; Vol. 7, No. 7.
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