Abstract
Background: Although the natural history of urothelial carcinoma of the bladder (UCB) from radical cystectomy (RC) to disease recurrence (DR) has been investigated intensively, the course of patients who have experienced DR after RC for UCB remains poorly understood. Objective: To evaluate the prognostic value of the Bajorin criteria that consists of two risk factors: Karnofsky performance status (KPS) and the presence of visceral metastases (VMs) in patients with DR after RC for UCB. Furthermore, to identify additional factors associated with cancer-specific mortality (CSM) and thus build a multivariable model to predict survival after DR. Design, setting, and participants: We identified 967 patients with UCB who underwent RC at 17 centers between 1979 and 2012 and experienced DR. Of these, 372 patients had complete data we used for analysis. Outcomes measurements and statistical analysis: Univariable Cox regressions analysis was performed. We used a forward stepwise selection process for our final multivariable model. Results and limitations: Within a median follow-up of 18 mo, 266 patients died of disease. Cancer-specific survival at 1 yr was 79%, 76%, and 47% for patients with no (n= 105), one (n= 180), and two (n= 87) risk factors (p<0.001; c-index: 0.604). On multivariable analyses, we found that KPS
| Original language | English |
|---|---|
| Pages (from-to) | 75-81 |
| Number of pages | 7 |
| Journal | European Urology Focus |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 Aug 1 |
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Keywords
- Bladder cancer
- Disease recurrence
- Metastasis
- Model
- Prognosis
- Survival
- Transitional cell carcinoma
- Urothelial carcinoma of the bladder
ASJC Scopus subject areas
- Urology
Cite this
Prognostic Model for Predicting Survival in Patients with Disease Recurrence Following Radical Cystectomy. / Kluth, Luis A.; Xylinas, Evanguelos; Rieken, Malte; Kent, Matthew; Ikeda, Masaomi; Matsumoto, Kazumasa; Hagiwara, Masayuki; Kikuchi, Eiji; Bing, Megan T.; Gupta, Amit; Sewell, Joseph M.; Konety, Badrinath R.; Todenhöfer, Tilman; Schwentner, Christian; Masson-Lecomte, Alexandra; Vordos, Dimitri; Roghmann, Florian; Noldus, Joachim; Razmaria, Aria A.; Smith, Norm D.; Comploj, Evi; Pycha, Armin; Rink, Michael; Baniel, Jack; Mano, Roy; Novara, Giacomo; Aziz, Atiqullah; Fritsche, Hans Martin; Brisuda, Antonin; Bivalacqua, Trinity; Gontero, Paolo; Boorjian, Stephen A.; Vickers, Andrew J.; Shariat, Shahrokh F.
In: European Urology Focus, Vol. 1, No. 1, 01.08.2015, p. 75-81.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic Model for Predicting Survival in Patients with Disease Recurrence Following Radical Cystectomy
AU - Kluth, Luis A.
AU - Xylinas, Evanguelos
AU - Rieken, Malte
AU - Kent, Matthew
AU - Ikeda, Masaomi
AU - Matsumoto, Kazumasa
AU - Hagiwara, Masayuki
AU - Kikuchi, Eiji
AU - Bing, Megan T.
AU - Gupta, Amit
AU - Sewell, Joseph M.
AU - Konety, Badrinath R.
AU - Todenhöfer, Tilman
AU - Schwentner, Christian
AU - Masson-Lecomte, Alexandra
AU - Vordos, Dimitri
AU - Roghmann, Florian
AU - Noldus, Joachim
AU - Razmaria, Aria A.
AU - Smith, Norm D.
AU - Comploj, Evi
AU - Pycha, Armin
AU - Rink, Michael
AU - Baniel, Jack
AU - Mano, Roy
AU - Novara, Giacomo
AU - Aziz, Atiqullah
AU - Fritsche, Hans Martin
AU - Brisuda, Antonin
AU - Bivalacqua, Trinity
AU - Gontero, Paolo
AU - Boorjian, Stephen A.
AU - Vickers, Andrew J.
AU - Shariat, Shahrokh F.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background: Although the natural history of urothelial carcinoma of the bladder (UCB) from radical cystectomy (RC) to disease recurrence (DR) has been investigated intensively, the course of patients who have experienced DR after RC for UCB remains poorly understood. Objective: To evaluate the prognostic value of the Bajorin criteria that consists of two risk factors: Karnofsky performance status (KPS) and the presence of visceral metastases (VMs) in patients with DR after RC for UCB. Furthermore, to identify additional factors associated with cancer-specific mortality (CSM) and thus build a multivariable model to predict survival after DR. Design, setting, and participants: We identified 967 patients with UCB who underwent RC at 17 centers between 1979 and 2012 and experienced DR. Of these, 372 patients had complete data we used for analysis. Outcomes measurements and statistical analysis: Univariable Cox regressions analysis was performed. We used a forward stepwise selection process for our final multivariable model. Results and limitations: Within a median follow-up of 18 mo, 266 patients died of disease. Cancer-specific survival at 1 yr was 79%, 76%, and 47% for patients with no (n= 105), one (n= 180), and two (n= 87) risk factors (p<0.001; c-index: 0.604). On multivariable analyses, we found that KPS
AB - Background: Although the natural history of urothelial carcinoma of the bladder (UCB) from radical cystectomy (RC) to disease recurrence (DR) has been investigated intensively, the course of patients who have experienced DR after RC for UCB remains poorly understood. Objective: To evaluate the prognostic value of the Bajorin criteria that consists of two risk factors: Karnofsky performance status (KPS) and the presence of visceral metastases (VMs) in patients with DR after RC for UCB. Furthermore, to identify additional factors associated with cancer-specific mortality (CSM) and thus build a multivariable model to predict survival after DR. Design, setting, and participants: We identified 967 patients with UCB who underwent RC at 17 centers between 1979 and 2012 and experienced DR. Of these, 372 patients had complete data we used for analysis. Outcomes measurements and statistical analysis: Univariable Cox regressions analysis was performed. We used a forward stepwise selection process for our final multivariable model. Results and limitations: Within a median follow-up of 18 mo, 266 patients died of disease. Cancer-specific survival at 1 yr was 79%, 76%, and 47% for patients with no (n= 105), one (n= 180), and two (n= 87) risk factors (p<0.001; c-index: 0.604). On multivariable analyses, we found that KPS
KW - Bladder cancer
KW - Disease recurrence
KW - Metastasis
KW - Model
KW - Prognosis
KW - Survival
KW - Transitional cell carcinoma
KW - Urothelial carcinoma of the bladder
UR - http://www.scopus.com/inward/record.url?scp=84940948204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940948204&partnerID=8YFLogxK
U2 - 10.1016/j.euf.2014.10.003
DO - 10.1016/j.euf.2014.10.003
M3 - Article
AN - SCOPUS:84940948204
VL - 1
SP - 75
EP - 81
JO - European Urology Focus
JF - European Urology Focus
SN - 2405-4569
IS - 1
ER -