Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma

T. Morii, H. Yabe, H. Morioka, R. Yamada, T. Nakagawa, Y. Toyama

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The plasminogen activation system plays an important role in enhancing pericellular proteolysis of tumor invasion/metastasis and in autocrine/paracrine tumor growth stimulation. To investigate the prognostic significance of the plasminogen activation system in human chondrosarcoma, the immunohistochemical expression of urokinase-type plasminogen activator (uPA), urokinase-type plasminogen activator receptor (uPAR), plasminogen activator inhibitor, 1 (PAI-1) and 2 (PAI-2) were analyzed in 28 patients with chondrosarcoma. In multivariate survival analysis, histological grade (p=0.0008) and location (p=0.02) were independent risk factors for local relapse. For metastasis-free survival, uPA index (p=0.006) and PAI-2 index (p=0.04) were independent prognostic factors. PAI-2 index (p=0.02), uPAR index (p=0.02) and histological grade (p=0.03) predicted total survival. These results demonstrated the usefulness of uPA, uPAR and PAI-2 expression as biological prognostic indicator and the importance of the plasminogen activation system in tumor progression and metastasis in chondrosarcoma.

Original languageEnglish
Pages (from-to)3031-3036
Number of pages6
JournalAnticancer Research
Volume20
Issue number5
Publication statusPublished - 2000

Fingerprint

Plasminogen Activator Inhibitor 2
Urokinase Plasminogen Activator Receptors
Plasminogen Inactivators
Chondrosarcoma
Plasminogen Activator Inhibitor 1
Plasminogen
Urokinase-Type Plasminogen Activator
Neoplasm Metastasis
Neoplasms
Survival
Survival Analysis
Proteolysis
Multivariate Analysis
Recurrence
Growth

Keywords

  • Chondrosarcoma
  • Immunohistochemistry
  • Plasminogen activator inhibitor (PAI)
  • Survival analysis
  • Urokinase-type plasminogen activator (uPA)
  • Urokinase-type plasminogen activator receptor (uPAR)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Morii, T., Yabe, H., Morioka, H., Yamada, R., Nakagawa, T., & Toyama, Y. (2000). Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma. Anticancer Research, 20(5), 3031-3036.

Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma. / Morii, T.; Yabe, H.; Morioka, H.; Yamada, R.; Nakagawa, T.; Toyama, Y.

In: Anticancer Research, Vol. 20, No. 5, 2000, p. 3031-3036.

Research output: Contribution to journalArticle

Morii, T, Yabe, H, Morioka, H, Yamada, R, Nakagawa, T & Toyama, Y 2000, 'Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma', Anticancer Research, vol. 20, no. 5, pp. 3031-3036.
Morii T, Yabe H, Morioka H, Yamada R, Nakagawa T, Toyama Y. Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma. Anticancer Research. 2000;20(5):3031-3036.
Morii, T. ; Yabe, H. ; Morioka, H. ; Yamada, R. ; Nakagawa, T. ; Toyama, Y. / Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma. In: Anticancer Research. 2000 ; Vol. 20, No. 5. pp. 3031-3036.
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