Abstract
The plasminogen activation system plays an important role in enhancing pericellular proteolysis of tumor invasion/metastasis and in autocrine/paracrine tumor growth stimulation. To investigate the prognostic significance of the plasminogen activation system in human chondrosarcoma, the immunohistochemical expression of urokinase-type plasminogen activator (uPA), urokinase-type plasminogen activator receptor (uPAR), plasminogen activator inhibitor, 1 (PAI-1) and 2 (PAI-2) were analyzed in 28 patients with chondrosarcoma. In multivariate survival analysis, histological grade (p=0.0008) and location (p=0.02) were independent risk factors for local relapse. For metastasis-free survival, uPA index (p=0.006) and PAI-2 index (p=0.04) were independent prognostic factors. PAI-2 index (p=0.02), uPAR index (p=0.02) and histological grade (p=0.03) predicted total survival. These results demonstrated the usefulness of uPA, uPAR and PAI-2 expression as biological prognostic indicator and the importance of the plasminogen activation system in tumor progression and metastasis in chondrosarcoma.
| Original language | English |
|---|---|
| Pages (from-to) | 3031-3036 |
| Number of pages | 6 |
| Journal | Anticancer research |
| Volume | 20 |
| Issue number | 5 |
| Publication status | Published - 2000 |
| Externally published | Yes |
Keywords
- Chondrosarcoma
- Immunohistochemistry
- Plasminogen activator inhibitor (PAI)
- Survival analysis
- Urokinase-type plasminogen activator (uPA)
- Urokinase-type plasminogen activator receptor (uPAR)
ASJC Scopus subject areas
- Oncology
- Cancer Research
