Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma

T. Morii, H. Yabe, H. Morioka, R. Yamada, T. Nakagawa, Y. Toyama

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The plasminogen activation system plays an important role in enhancing pericellular proteolysis of tumor invasion/metastasis and in autocrine/paracrine tumor growth stimulation. To investigate the prognostic significance of the plasminogen activation system in human chondrosarcoma, the immunohistochemical expression of urokinase-type plasminogen activator (uPA), urokinase-type plasminogen activator receptor (uPAR), plasminogen activator inhibitor, 1 (PAI-1) and 2 (PAI-2) were analyzed in 28 patients with chondrosarcoma. In multivariate survival analysis, histological grade (p=0.0008) and location (p=0.02) were independent risk factors for local relapse. For metastasis-free survival, uPA index (p=0.006) and PAI-2 index (p=0.04) were independent prognostic factors. PAI-2 index (p=0.02), uPAR index (p=0.02) and histological grade (p=0.03) predicted total survival. These results demonstrated the usefulness of uPA, uPAR and PAI-2 expression as biological prognostic indicator and the importance of the plasminogen activation system in tumor progression and metastasis in chondrosarcoma.

Original languageEnglish
Pages (from-to)3031-3036
Number of pages6
JournalAnticancer research
Volume20
Issue number5
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Chondrosarcoma
  • Immunohistochemistry
  • Plasminogen activator inhibitor (PAI)
  • Survival analysis
  • Urokinase-type plasminogen activator (uPA)
  • Urokinase-type plasminogen activator receptor (uPAR)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Morii, T., Yabe, H., Morioka, H., Yamada, R., Nakagawa, T., & Toyama, Y. (2000). Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma. Anticancer research, 20(5), 3031-3036.