Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma

Yutaka Shimada, Yosuke Hashimoto, Takatsugu Kan, Jun Ichiro Kawamura, Tomoyuki Okumura, Toshiya Soma, Kan Kondo, Naoki Teratani, Go Watanabe, Yoshinori Ino, Michiie Sakamoto, Setsuo Hirohashi, Masayuki Imamura

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Objective: Dysadherin is a cancer-associated cell membrane glycoprotein that has been reported to downregulate E-cadherin expression and promote metastasis. To evaluate the role of dysadherin in metastasis of esophageal squamous cell carcinoma (ESCC), we examined dysadherin and E-cadherin expression in patients with this cancer. Methods: Dysadherin and E-cadherin expression was evaluated in 117 ESCC patients (pT1, 31; pT2, 30; pT3, 39; pT4, 17) by immunohistochemistry. The findings were compared with the clinicopathological data of the patients. Results: Both dysadherin and E-cadherin were localized to the cell membrane. Thirty patients (29.1%) had tumors positive for dysadherin and 41 patients (35.0%) had tumors positive for E-cadherin. Tumors showing dysadherin positivity and negative E-cadherin expression had a significantly worse prognosis than other tumors. When the patients with dysadherinpositive tumors were combined with E-cadherin-negative patients, this group had a worse prognosis (p < 0.0001). Cox multivariate analysis revealed that dysadherin expression was an independent prognostic factor for ESCC (p = 0.003), but E-cadherin expression was not. Conclusion: Combined analysis of dysadherin and E-cadherin expression may help to predict the prognosis of patients with ESCC. Our results suggested that expression of dysadherin by this cancer may partly explain the poor prognosis of patients with preservation of E-cadherin expression.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalOncology
Volume67
Issue number1
DOIs
Publication statusPublished - 2004 Oct 27

Keywords

  • Cell-cell adhesion
  • E-cadherin
  • Esophageal cancer
  • Lymph node metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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