Prognostic significance of HLA class I expression in Ewing's sarcoma family of tumors

Hiroki Yabe, Tomohide Tsukahara, Satoshi Kawaguchi, Takuro Wada, Toshihiko Torigoe, Noriyuki Sato, Chihiro Terai, Masaya Aoki, Shigemichi Hirose, Hideo Morioka, Hiroo Yabe

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17 Citations (Scopus)

Abstract

Background: Ewing's sarcoma family of tumors (ESFT) is one of the most malignant groups of tumors in young people. Human leukocyte antigen (HLA) class I displays endogenously processed peptides to CD8+ T lymphocytes and has a key role for host immune surveillance. In ESFT, the investigation concerning both HLA class I expression and T-cell infiltration has yet to be reported. Methods: Biopsy specimens from 28 ESFT patients were evaluated by immunohistochemistry with the anti-HLA class I monoclonal antibody (mAb) EMR8-5 and anti-CD8 mAb, respectively. Results: Expression of HLA class I was negative in 10 tumors and down-regulated in 22 tumors. The status of CD8+ T cell infiltration was closely associated with the expression levels of HLA class I. ESFT patients with down-regulated or negative expression of HLA class I showed significantly poorer survival than the rest of the patients. Conclusions: Our results suggested that CD8+ T cell-mediated immune response restricted by HLA class I might play an important role in immune surveillance of ESFT, and we revealed for the first time that the status of HLA class I expression affects the survival of the patients with ESFT.

Original languageEnglish
Pages (from-to)380-385
Number of pages6
JournalJournal of Surgical Oncology
Volume103
Issue number5
DOIs
Publication statusPublished - 2011 Apr 1

Keywords

  • CD8
  • ESFT
  • Ewing's
  • Hla class I
  • Sarcoma
  • T lymphocyte

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Yabe, H., Tsukahara, T., Kawaguchi, S., Wada, T., Torigoe, T., Sato, N., Terai, C., Aoki, M., Hirose, S., Morioka, H., & Yabe, H. (2011). Prognostic significance of HLA class I expression in Ewing's sarcoma family of tumors. Journal of Surgical Oncology, 103(5), 380-385. https://doi.org/10.1002/jso.21829