Abstract
Background:Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC.Patients and methods:One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Met high and c-Met low groups. Clinicopathological factors and outcomes were compared between the groups. c-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines.Results:The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Met high expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. c-Met high expression was significantly correlated with the 5-year survival rate for CC overall (P0.0046) and for IHCC (P0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Met high expression was an independent predictor of poor overall and disease-free survival in patients with IHCC.Conclusions:c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC.
| Original language | English |
|---|---|
| Pages (from-to) | 131-138 |
| Number of pages | 8 |
| Journal | British Journal of Cancer |
| Volume | 105 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 Jun 28 |
| Externally published | Yes |
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Keywords
- c-Met
- cholangiocarcinoma
- epidermal growth factor receptor
- immunohistochemistry
- prognostic factor
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma. / Miyamoto, M.; Ojima, Hidenori; Iwasaki, M.; Shimizu, H.; Kokubu, A.; Hiraoka, N.; Kosuge, T.; Yoshikawa, D.; Kono, T.; Furukawa, H.; Shibata, T.
In: British Journal of Cancer, Vol. 105, No. 1, 28.06.2011, p. 131-138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma
AU - Miyamoto, M.
AU - Ojima, Hidenori
AU - Iwasaki, M.
AU - Shimizu, H.
AU - Kokubu, A.
AU - Hiraoka, N.
AU - Kosuge, T.
AU - Yoshikawa, D.
AU - Kono, T.
AU - Furukawa, H.
AU - Shibata, T.
PY - 2011/6/28
Y1 - 2011/6/28
N2 - Background:Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC.Patients and methods:One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Met high and c-Met low groups. Clinicopathological factors and outcomes were compared between the groups. c-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines.Results:The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Met high expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. c-Met high expression was significantly correlated with the 5-year survival rate for CC overall (P0.0046) and for IHCC (P0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Met high expression was an independent predictor of poor overall and disease-free survival in patients with IHCC.Conclusions:c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC.
AB - Background:Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC.Patients and methods:One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Met high and c-Met low groups. Clinicopathological factors and outcomes were compared between the groups. c-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines.Results:The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Met high expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. c-Met high expression was significantly correlated with the 5-year survival rate for CC overall (P0.0046) and for IHCC (P0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Met high expression was an independent predictor of poor overall and disease-free survival in patients with IHCC.Conclusions:c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC.
KW - c-Met
KW - cholangiocarcinoma
KW - epidermal growth factor receptor
KW - immunohistochemistry
KW - prognostic factor
UR - http://www.scopus.com/inward/record.url?scp=79959731074&partnerID=8YFLogxK
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U2 - 10.1038/bjc.2011.199
DO - 10.1038/bjc.2011.199
M3 - Article
VL - 105
SP - 131
EP - 138
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 1
ER -