Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma

M. Miyamoto, H. Ojima, M. Iwasaki, H. Shimizu, A. Kokubu, N. Hiraoka, T. Kosuge, D. Yoshikawa, T. Kono, H. Furukawa, T. Shibata

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74 Citations (Scopus)


Background:Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC.Patients and methods:One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Met high and c-Met low groups. Clinicopathological factors and outcomes were compared between the groups. c-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines.Results:The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Met high expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. c-Met high expression was significantly correlated with the 5-year survival rate for CC overall (P0.0046) and for IHCC (P0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Met high expression was an independent predictor of poor overall and disease-free survival in patients with IHCC.Conclusions:c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC.

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalBritish Journal of Cancer
Issue number1
Publication statusPublished - 2011 Jun 28
Externally publishedYes


  • c-Met
  • cholangiocarcinoma
  • epidermal growth factor receptor
  • immunohistochemistry
  • prognostic factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Miyamoto, M., Ojima, H., Iwasaki, M., Shimizu, H., Kokubu, A., Hiraoka, N., Kosuge, T., Yoshikawa, D., Kono, T., Furukawa, H., & Shibata, T. (2011). Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma. British Journal of Cancer, 105(1), 131-138.