Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma

M. Miyamoto, Hidenori Ojima, M. Iwasaki, H. Shimizu, A. Kokubu, N. Hiraoka, T. Kosuge, D. Yoshikawa, T. Kono, H. Furukawa, T. Shibata

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background:Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC.Patients and methods:One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Met high and c-Met low groups. Clinicopathological factors and outcomes were compared between the groups. c-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines.Results:The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Met high expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. c-Met high expression was significantly correlated with the 5-year survival rate for CC overall (P0.0046) and for IHCC (P0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Met high expression was an independent predictor of poor overall and disease-free survival in patients with IHCC.Conclusions:c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC.

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalBritish Journal of Cancer
Volume105
Issue number1
DOIs
Publication statusPublished - 2011 Jun 28
Externally publishedYes

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Cholangiocarcinoma
Oncogene Proteins
Epidermal Growth Factor Receptor
Cell Line
Disease-Free Survival
Multivariate Analysis
Survival Rate
Carcinoma

Keywords

  • c-Met
  • cholangiocarcinoma
  • epidermal growth factor receptor
  • immunohistochemistry
  • prognostic factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Miyamoto, M., Ojima, H., Iwasaki, M., Shimizu, H., Kokubu, A., Hiraoka, N., ... Shibata, T. (2011). Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma. British Journal of Cancer, 105(1), 131-138. https://doi.org/10.1038/bjc.2011.199

Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma. / Miyamoto, M.; Ojima, Hidenori; Iwasaki, M.; Shimizu, H.; Kokubu, A.; Hiraoka, N.; Kosuge, T.; Yoshikawa, D.; Kono, T.; Furukawa, H.; Shibata, T.

In: British Journal of Cancer, Vol. 105, No. 1, 28.06.2011, p. 131-138.

Research output: Contribution to journalArticle

Miyamoto, M, Ojima, H, Iwasaki, M, Shimizu, H, Kokubu, A, Hiraoka, N, Kosuge, T, Yoshikawa, D, Kono, T, Furukawa, H & Shibata, T 2011, 'Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma', British Journal of Cancer, vol. 105, no. 1, pp. 131-138. https://doi.org/10.1038/bjc.2011.199
Miyamoto, M. ; Ojima, Hidenori ; Iwasaki, M. ; Shimizu, H. ; Kokubu, A. ; Hiraoka, N. ; Kosuge, T. ; Yoshikawa, D. ; Kono, T. ; Furukawa, H. ; Shibata, T. / Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma. In: British Journal of Cancer. 2011 ; Vol. 105, No. 1. pp. 131-138.
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AU - Hiraoka, N.

AU - Kosuge, T.

AU - Yoshikawa, D.

AU - Kono, T.

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AU - Shibata, T.

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