Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma

Nobuhiro Nitori, Yoshinori Ino, Yukihiro Nakanishi, Tesshi Yamada, Kazufumi Honda, Kazuyoshi Yanagihara, Tomoo Kosuge, Yae Kanai, Masaki Kitajima, Setsuo Hirohashi, Tsuo Tirchashi

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Tissue factor (TF) is a transmembrane glycoprotein that plays roles in the blood coagulation and intracellular signaling pathways, and has also been suggested to modulate the biological behavior of cancer cells. In order to examine the clinicopathologic significance of TF expression in pancreatic ductal adenocarcinoma, TF expression was determined by immunohistochemistry using a newly raised anti-TF monoclonal antibody in 113 patients who had undergone surgical resection of pancreatic ductal adenocarcinoma. According to the incidence of tumor cell immunopositivity, patients were divided into "negative TF" (0%), "weak TF" (<25%), or "high TF" (25% or more) groups, which accounted for 11.6% (n = 13), 44.2% (n = 50), and 44.2% (n = 50) of the total, respectively. Increased TF expression was correlated with the extent of the primary tumor (P = 0.0043), lymph node metastasis (P = 0.0043), lymphatic distant metastasis (P = 0.0039), advanced tumor-node-metastasis stage (P = 0.0002), and high tumor grade (P = 0.0164). Multivariate analysis using the Cox proportional hazards model showed that high TF expression was an independent negative predictor for survival (hazard ratio, 2.014; P = 0.0076). Moreover, patients with TF-negative tumors had a significantly better prognosis even if lymph node metastasis was present (P < 0.0001). We also showed that TF knockdown by RNA interference suppressed the invasiveness of a pancreatic adenocarcinoma cell line in vitro. These results indicate that TF expression may contribute to the aggressiveness of pancreatic ductal adenocarcinoma by stimulating tumor invasiveness, and that evaluation of the primary tumor for TF expression may identify patients with a poor prognosis.

Original languageEnglish
Pages (from-to)2531-2539
Number of pages9
JournalClinical Cancer Research
Volume11
Issue number7
DOIs
Publication statusPublished - 2005 Apr 1
Externally publishedYes

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Thromboplastin
Adenocarcinoma
Neoplasms
Neoplasm Metastasis
Lymph Nodes
Lymphatic Metastasis
Blood Coagulation
RNA Interference
Proportional Hazards Models
Glycoproteins
Multivariate Analysis
Immunohistochemistry
Monoclonal Antibodies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nitori, N., Ino, Y., Nakanishi, Y., Yamada, T., Honda, K., Yanagihara, K., ... Tirchashi, T. (2005). Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clinical Cancer Research, 11(7), 2531-2539. https://doi.org/10.1158/1078-0432.CCR-04-0866

Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. / Nitori, Nobuhiro; Ino, Yoshinori; Nakanishi, Yukihiro; Yamada, Tesshi; Honda, Kazufumi; Yanagihara, Kazuyoshi; Kosuge, Tomoo; Kanai, Yae; Kitajima, Masaki; Hirohashi, Setsuo; Tirchashi, Tsuo.

In: Clinical Cancer Research, Vol. 11, No. 7, 01.04.2005, p. 2531-2539.

Research output: Contribution to journalArticle

Nitori, N, Ino, Y, Nakanishi, Y, Yamada, T, Honda, K, Yanagihara, K, Kosuge, T, Kanai, Y, Kitajima, M, Hirohashi, S & Tirchashi, T 2005, 'Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma', Clinical Cancer Research, vol. 11, no. 7, pp. 2531-2539. https://doi.org/10.1158/1078-0432.CCR-04-0866
Nitori N, Ino Y, Nakanishi Y, Yamada T, Honda K, Yanagihara K et al. Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clinical Cancer Research. 2005 Apr 1;11(7):2531-2539. https://doi.org/10.1158/1078-0432.CCR-04-0866
Nitori, Nobuhiro ; Ino, Yoshinori ; Nakanishi, Yukihiro ; Yamada, Tesshi ; Honda, Kazufumi ; Yanagihara, Kazuyoshi ; Kosuge, Tomoo ; Kanai, Yae ; Kitajima, Masaki ; Hirohashi, Setsuo ; Tirchashi, Tsuo. / Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. In: Clinical Cancer Research. 2005 ; Vol. 11, No. 7. pp. 2531-2539.
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AU - Yanagihara, Kazuyoshi

AU - Kosuge, Tomoo

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