Prognostic stratification in patients who received hormonal therapy for prostate-specific antigen recurrence after radical prostatectomy

Hiroki Ide, Jun Nakashima, Hidaka Kono, Eiji Kikuchi, Hirohiko Nagata, Akira Miyajima, Ken Nakagawa, Mototsugu Oya

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The present study was undertaken to investigate the predictors in patients who received hormonal therapy (HT) for prostate-specific antigen recurrence (PSAR) after surgery. Predictors for the progression-free survival were assessed in 55 patients who received HT for PSAR after surgery. In multivariate analysis, primary Gleason grade ≥4 and PSA doubling time (PSA-DT) <6 months were independent predictors. The patients were stratified into low-risk group (Gleason grade <4 and PSA-DT ≥6), high-risk group (Gleason grade ≥4 and PSA-DT <6) and intermediate-risk group (all others). In the intermediate-and high-risk groups, progression-free survival rate was significantly higher in patients with PSA level <2 than in those with PSA level ≥2 at the initiation of HT. Primary Gleason grade ≥4 and PSA-DT <6 months are independent predictors. Patients in the intermediate-and high-risk groups may benefit from early HT for PSAR after surgery.

Original languageEnglish
Article numberhyp133
Pages (from-to)177-180
Number of pages4
JournalJapanese journal of clinical oncology
Volume40
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

Keywords

  • Gleason grade
  • Hormonal therapy
  • PSA doubling time
  • Prostate cancer
  • Radical prostatectomy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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