Prognostic utility of molecular factors by age at diagnosis of colorectal cancer

Nadine J. McCleary, Kaori Sato, Reiko Nishihara, Kentaro Inamura, Teppei Morikawa, Xuehong Zhang, Kana Wu, Mai Yamauchi, Sun A. Kim, Yasutaka Sukawa, Kosuke Mima, Zhi Rong Qian, Charles S. Fuchs, Shuji Ogino, Jeffrey A. Meyerhardt

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose:Wehypothesized that adverse prognostic associations of specific tumor molecular factors vary by patient age at colorectal cancer diagnosis. ExperimentalDesign:Weexamined the prognostic associations and interactions by age at colorectal cancer diagnosis (interaction = 0.03 for CSS; Pinteraction = 0.007 for OS). Conclusions: Tumor nuclear CTNNB1 expression may be associated with higher mortality among older patients with colorectal cancer but not among younger patients. Our findings need to be confirmed in independent datasets. Detailed exploration of tumor molecular signatures in older patients with colorectal cancer in large populations is warranted. Clin Cancer Res; 22(6); 1489-98.

Original languageEnglish
Pages (from-to)1489-1498
Number of pages10
JournalClinical Cancer Research
Volume22
Issue number6
DOIs
Publication statusPublished - 2016 Mar 15
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

McCleary, N. J., Sato, K., Nishihara, R., Inamura, K., Morikawa, T., Zhang, X., Wu, K., Yamauchi, M., Kim, S. A., Sukawa, Y., Mima, K., Rong Qian, Z., Fuchs, C. S., Ogino, S., & Meyerhardt, J. A. (2016). Prognostic utility of molecular factors by age at diagnosis of colorectal cancer. Clinical Cancer Research, 22(6), 1489-1498. https://doi.org/10.1158/1078-0432.CCR-15-0946