Purpose:Wehypothesized that adverse prognostic associations of specific tumor molecular factors vary by patient age at colorectal cancer diagnosis. ExperimentalDesign:Weexamined the prognostic associations and interactions by age at colorectal cancer diagnosis (interaction = 0.03 for CSS; Pinteraction = 0.007 for OS). Conclusions: Tumor nuclear CTNNB1 expression may be associated with higher mortality among older patients with colorectal cancer but not among younger patients. Our findings need to be confirmed in independent datasets. Detailed exploration of tumor molecular signatures in older patients with colorectal cancer in large populations is warranted. Clin Cancer Res; 22(6); 1489-98.
ASJC Scopus subject areas
- Cancer Research