Prognostic value of cerebral blood flow autoregulation in the long-term prognosis of ischemic cerebrovascular disease

Hisao Tachibana, Fumio Gotoh, Shin Ichiro Ebihara, Hiroyuki Okayasu, Yasuhisa Kitagawa, Takashi Hata, Norihiro Suzuki, Nobuo Araki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The correlation between long-term prognosis, cerebral blood flow (CBF) and CBF autoregulation was studied in 34 patients with cerebral infarction (mean age, 64 years). CBF was measured by the nitrous oxide method 1-6 months (mean 87 days) after disease onset. CBF autoregulation was evaluated quantitatively from the Dysautoregulation Index (DI) (ΔCBF/Δeffective MABP). Reductions in effective MABP were induced with a tilt table. No significant correlation was noted among CBF, DI and activities of daily living at the time of measurement. The patients' physical condition was reevaluated by questionnaire 2 years or more (mean 32 months) later. Better functional state at follow-up was related to higher CBF and lower DI values although the differences were not significant. The relationships among CBF, DI and changes in physical condition during the period were evaluated. The mean CBF values in patients with a better prognosis exceeded those of poor prognosis patients. The CBF values in the group who became independent significantly exceeded those in the group that deteriorated (P < 0.05). The CBF values in the latter showed small but significant decreases during head-up tilting (P < 0.05). The DI in this group was significantly higher than in the groups with a less severe outcome (P < 0.01, P < 0.05, respectively). In conclusion, determinations of CBF autoregulation, together with flow values, in the chronic state may have some value in predicting the long-term prognosis in cerebral infarction.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalJournal of the Neurological Sciences
Volume60
Issue number2
DOIs
Publication statusPublished - 1983

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Cerebrovascular Circulation
Cerebrovascular Disorders
Homeostasis
Cerebral Infarction
Nitrous Oxide
Activities of Daily Living

Keywords

  • Autoregulation
  • Cerebral blood flow
  • Cerebral infarction
  • Prognosis of stroke

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Prognostic value of cerebral blood flow autoregulation in the long-term prognosis of ischemic cerebrovascular disease. / Tachibana, Hisao; Gotoh, Fumio; Ebihara, Shin Ichiro; Okayasu, Hiroyuki; Kitagawa, Yasuhisa; Hata, Takashi; Suzuki, Norihiro; Araki, Nobuo.

In: Journal of the Neurological Sciences, Vol. 60, No. 2, 1983, p. 197-204.

Research output: Contribution to journalArticle

Tachibana, H, Gotoh, F, Ebihara, SI, Okayasu, H, Kitagawa, Y, Hata, T, Suzuki, N & Araki, N 1983, 'Prognostic value of cerebral blood flow autoregulation in the long-term prognosis of ischemic cerebrovascular disease', Journal of the Neurological Sciences, vol. 60, no. 2, pp. 197-204. https://doi.org/10.1016/0022-510X(83)90062-X
Tachibana, Hisao ; Gotoh, Fumio ; Ebihara, Shin Ichiro ; Okayasu, Hiroyuki ; Kitagawa, Yasuhisa ; Hata, Takashi ; Suzuki, Norihiro ; Araki, Nobuo. / Prognostic value of cerebral blood flow autoregulation in the long-term prognosis of ischemic cerebrovascular disease. In: Journal of the Neurological Sciences. 1983 ; Vol. 60, No. 2. pp. 197-204.
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N2 - The correlation between long-term prognosis, cerebral blood flow (CBF) and CBF autoregulation was studied in 34 patients with cerebral infarction (mean age, 64 years). CBF was measured by the nitrous oxide method 1-6 months (mean 87 days) after disease onset. CBF autoregulation was evaluated quantitatively from the Dysautoregulation Index (DI) (ΔCBF/Δeffective MABP). Reductions in effective MABP were induced with a tilt table. No significant correlation was noted among CBF, DI and activities of daily living at the time of measurement. The patients' physical condition was reevaluated by questionnaire 2 years or more (mean 32 months) later. Better functional state at follow-up was related to higher CBF and lower DI values although the differences were not significant. The relationships among CBF, DI and changes in physical condition during the period were evaluated. The mean CBF values in patients with a better prognosis exceeded those of poor prognosis patients. The CBF values in the group who became independent significantly exceeded those in the group that deteriorated (P < 0.05). The CBF values in the latter showed small but significant decreases during head-up tilting (P < 0.05). The DI in this group was significantly higher than in the groups with a less severe outcome (P < 0.01, P < 0.05, respectively). In conclusion, determinations of CBF autoregulation, together with flow values, in the chronic state may have some value in predicting the long-term prognosis in cerebral infarction.

AB - The correlation between long-term prognosis, cerebral blood flow (CBF) and CBF autoregulation was studied in 34 patients with cerebral infarction (mean age, 64 years). CBF was measured by the nitrous oxide method 1-6 months (mean 87 days) after disease onset. CBF autoregulation was evaluated quantitatively from the Dysautoregulation Index (DI) (ΔCBF/Δeffective MABP). Reductions in effective MABP were induced with a tilt table. No significant correlation was noted among CBF, DI and activities of daily living at the time of measurement. The patients' physical condition was reevaluated by questionnaire 2 years or more (mean 32 months) later. Better functional state at follow-up was related to higher CBF and lower DI values although the differences were not significant. The relationships among CBF, DI and changes in physical condition during the period were evaluated. The mean CBF values in patients with a better prognosis exceeded those of poor prognosis patients. The CBF values in the group who became independent significantly exceeded those in the group that deteriorated (P < 0.05). The CBF values in the latter showed small but significant decreases during head-up tilting (P < 0.05). The DI in this group was significantly higher than in the groups with a less severe outcome (P < 0.01, P < 0.05, respectively). In conclusion, determinations of CBF autoregulation, together with flow values, in the chronic state may have some value in predicting the long-term prognosis in cerebral infarction.

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