Prognostic value of preoperative multiparametric magnetic resonance imaging (MRI) for predicting biochemical recurrence after radical prostatectomy

Seiya Hattori, Takeo Kosaka, Ryuichi Mizuno, Kent Kanao, Akira Miyajima, Yota Yasumizu, Satoshi Yazawa, Hirohiko Nagata, Eiji Kikuchi, Shuji Mikami, Masahiro Jinzaki, Ken Nakagawa, Akihiro Tanimoto, Mototsugu Oya

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective To evaluate the suitability of preoperative multiparametric magnetic resonance imaging (MRI) positivity as a predictor of biochemical recurrence after radical prostatectomy (RP). Patients and Methods We reviewed the clinical records of patients who underwent either standard RP or laparoscopic RP between January 2005 and December 2009 at our institution. Patients who received radiotherapy or androgen deprivation therapy before surgery were excluded. A total of 314 patients met the study inclusion criteria. Cox proportional hazard regression models were used for analyses. In accordance with the criteria in the established guidelines, a radiologist scored the probability of the presence of prostate cancer using a five-point scale of diagnostic confidence level. The highest confidence level of any pulse sequence was considered as the evaluation result. Results MRI positivity was significantly associated with a high clinical stage (cT ≥ 2; P = 0.039), a high positive biopsy core rate (≥0.2; P < 0.001), a high biopsy Gleason score ([GS] ≥8; P < 0.001) and a high pathological GS (≥8; P = 0.005). Univariate analysis and multivariate analysis showed that MRI positivity was a prognostic indicator in the analysis that included only preoperative variables and also in the analysis including preoperative and pathological variables. Conclusion Multiparametric MRI positivity can independently predict biochemical recurrence after RP.

Original languageEnglish
Pages (from-to)741-747
Number of pages7
JournalBJU International
Volume113
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Prostatectomy
Magnetic Resonance Imaging
Recurrence
Neoplasm Grading
Biopsy
Proportional Hazards Models
Androgens
Prostatic Neoplasms
Radiotherapy
Multivariate Analysis
Guidelines
Therapeutics

Keywords

  • biochemical recurrence
  • clinical stage
  • MRI
  • prostate cancer
  • PSA
  • radical prostatectomy

ASJC Scopus subject areas

  • Urology

Cite this

Prognostic value of preoperative multiparametric magnetic resonance imaging (MRI) for predicting biochemical recurrence after radical prostatectomy. / Hattori, Seiya; Kosaka, Takeo; Mizuno, Ryuichi; Kanao, Kent; Miyajima, Akira; Yasumizu, Yota; Yazawa, Satoshi; Nagata, Hirohiko; Kikuchi, Eiji; Mikami, Shuji; Jinzaki, Masahiro; Nakagawa, Ken; Tanimoto, Akihiro; Oya, Mototsugu.

In: BJU International, Vol. 113, No. 5, 2014, p. 741-747.

Research output: Contribution to journalArticle

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AU - Miyajima, Akira

AU - Yasumizu, Yota

AU - Yazawa, Satoshi

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AU - Jinzaki, Masahiro

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N2 - Objective To evaluate the suitability of preoperative multiparametric magnetic resonance imaging (MRI) positivity as a predictor of biochemical recurrence after radical prostatectomy (RP). Patients and Methods We reviewed the clinical records of patients who underwent either standard RP or laparoscopic RP between January 2005 and December 2009 at our institution. Patients who received radiotherapy or androgen deprivation therapy before surgery were excluded. A total of 314 patients met the study inclusion criteria. Cox proportional hazard regression models were used for analyses. In accordance with the criteria in the established guidelines, a radiologist scored the probability of the presence of prostate cancer using a five-point scale of diagnostic confidence level. The highest confidence level of any pulse sequence was considered as the evaluation result. Results MRI positivity was significantly associated with a high clinical stage (cT ≥ 2; P = 0.039), a high positive biopsy core rate (≥0.2; P < 0.001), a high biopsy Gleason score ([GS] ≥8; P < 0.001) and a high pathological GS (≥8; P = 0.005). Univariate analysis and multivariate analysis showed that MRI positivity was a prognostic indicator in the analysis that included only preoperative variables and also in the analysis including preoperative and pathological variables. Conclusion Multiparametric MRI positivity can independently predict biochemical recurrence after RP.

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