Prognostic value of Q wave for cardiovascular death in a 19-year prospective study of the Japanese general population

Aya Higashiyama, Atsushi Hozawa, Yoshitaka Murakami, Tomonori Okamura, Makoto Watanabe, Yasuyuki Nakamura, Takehito Hayakawa, Takashi Kadowaki, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima, Osamu Iimura, Teruo Omae, Kazuo Ueda, Hiroshi Horibe, Kazunori Kodama, Fumiyoshi Kasagi, Shinichi Tanihara, Shigeyuki Saitoh, Kiyomi SakataYosikazu Nakamura, Fumihiko Kakuno, Toshihiro Takeuchi, Mitsuru Hasebe, Fumitsugu Kusano, Takahisa Kawamoto, Masumi Minowa, Katsuhiko Kawaminami, Sohel R. Choudhury, Yutaka Kiyohara, Minoru Iida, Tsutomu Hashimoto, Atsushi Terao, Koryo Sawai, Shigeo Shibata

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim: Little is known about the prognostic value of q wave abnormality for cardiovascular disease (CVD) on a resting electrocardiogram (ECG) of the Japanese general population with an extremely low incidence of myocardial infarction. Methods: We followed 8,339 participants without a past and present history of CVD for 19 years. The multivariate-adjusted hazard ratio (HR) of q wave abnormality for CVD mortality was estimated by the Cox proportional hazards model. Results: The multivariate-adjusted HR of composite findings of moderate or severe q wave abnormality was 1.75 (95% confidence interval (CI): 0.97-3.17) for mortality due to CVD and 2.97 (95%CI: 1.43-6.16) due to heart diseases. The multivariate-adjusted HR of mild abnormality for mortality from heart diseases was 1.95 (95%CI: 1.00-3.81). The relationship between moderate or severe abnormalities and mortality from CVD was unchanged when participants with ST-T changes and high amplitude R waves were excluded and when participants were divided by the presence of major CVD risk factors such as hypertension. Q wave abnormality was not associated with the risk of stroke. Conclusion: Moderate or severe q wave abnormalities are prominent and important predictors of mortality due to CVD and heart disease in the Japanese general population without CVD history.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalJournal of atherosclerosis and thrombosis
Volume16
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1
Externally publishedYes

Keywords

  • Cardiovascular diseases
  • Cohort study
  • Hazard ratio
  • Heart diseases

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

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    Higashiyama, A., Hozawa, A., Murakami, Y., Okamura, T., Watanabe, M., Nakamura, Y., Hayakawa, T., Kadowaki, T., Kita, Y., Okayama, A., Ueshima, H., Iimura, O., Omae, T., Ueda, K., Horibe, H., Kodama, K., Kasagi, F., Tanihara, S., Saitoh, S., ... Shibata, S. (2009). Prognostic value of Q wave for cardiovascular death in a 19-year prospective study of the Japanese general population. Journal of atherosclerosis and thrombosis, 16(1), 40-50. https://doi.org/10.5551/jat.E606