TY - JOUR
T1 - Prognostic value of ST-T abnormalities and left high R waves with cardiovascular mortality in Japanese (24-Year follow-up of NIPPON DATA80)
AU - Rumana, Nahid
AU - Turin, Tanvir Chowdhury
AU - Miura, Katsuyuki
AU - Nakamura, Yasuyuki
AU - Kita, Yoshikuni
AU - Hayakawa, Takehito
AU - Choudhury, Sohel Reza
AU - Kadota, Aya
AU - Nagasawa, Shin Ya
AU - Fujioshi, Akira
AU - Takashima, Naoyuki
AU - Okamura, Tomonori
AU - Okayama, Akira
AU - Ueshima, Hirotsugu
N1 - Funding Information:
This study was supported by a Grant-in-Aid from the Ministry of Health, Labor and Welfare under the auspices of the Japanese Association for Cerebrocardiovascular Disease Control ; Research Grant for Cardiovascular Diseases 7A-2 from the Ministry of Health, Labor and Welfare ; and the Health and Labor Sciences Research Grant, Tokyo, Japan ( Comprehensive Research on Aging and Health Grants H11-Chouju-046 , H14-Chouju-003 , H17-Chouju-012 , and H19-Chouju-Ippan-014 ; Comprehensive Research on Life-Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus Grant H22-Jyunkankitou-Seisyu-Sitei-017 ). Dr. Rumana is supported by a research fellowship and Research Grant-in-Aid P-21.09139 from the Japan Society of Promotion of Science , Tokyo, Japan.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/6/15
Y1 - 2011/6/15
N2 - Little is known about the prognostic value of ST-segment depression and/or T wave (ST-T abnormalities) with or without left high R waves on electrocardiogram recorded at rest for death from cardiovascular disease (CVD) in Asian populations. Japanese participants without a history of CVD and free of major electrocardiographic (ECG) abnormalities were followed for 24 years. Subjects were divided into 4 groups based on baseline ECG findings: isolated left high R waves, isolated ST-T abnormalities, ST-T abnormalities with left high R waves, and normal electrocardiogram. Cox proportional hazard model was used to estimate risk of CVD mortality in groups with ECG abnormalities compared to the normal group. Of 8,572 participants (44.4% men, mean age 49.5 years; 55.6% women, mean age 49.4 years), 1,142 had isolated left high R waves, 292 had isolated ST-T abnormalities, and 128 had ST-T abnormalities with left high R waves at baseline. Multivariable-adjusted hazard ratios of ST-T abnormalities with left high R waves for CVD mortality were 1.95 (95% confidence interval 1.25 to 3.04) in men and 2.68 (95% confidence interval 1.81 to 3.97) in women. Isolated ST-T abnormalities increased the risk for CVD death by 1.66 times (95% confidence interval 1.01 to 2.71) in men and 1.62 times (95% confidence interval 1.18 to 2.24) in women. Association of ECG abnormalities with CVD mortality was independent of age, body mass index, systolic blood pressure, serum cholesterol, blood glucose, smoking and drinking, and antihypertensive medication. In conclusion, ST-T abnormalities with or without left high R waves on electrocardiogram recorded at rest constitute an independent predictor of CVD mortality in Japanese men and women.
AB - Little is known about the prognostic value of ST-segment depression and/or T wave (ST-T abnormalities) with or without left high R waves on electrocardiogram recorded at rest for death from cardiovascular disease (CVD) in Asian populations. Japanese participants without a history of CVD and free of major electrocardiographic (ECG) abnormalities were followed for 24 years. Subjects were divided into 4 groups based on baseline ECG findings: isolated left high R waves, isolated ST-T abnormalities, ST-T abnormalities with left high R waves, and normal electrocardiogram. Cox proportional hazard model was used to estimate risk of CVD mortality in groups with ECG abnormalities compared to the normal group. Of 8,572 participants (44.4% men, mean age 49.5 years; 55.6% women, mean age 49.4 years), 1,142 had isolated left high R waves, 292 had isolated ST-T abnormalities, and 128 had ST-T abnormalities with left high R waves at baseline. Multivariable-adjusted hazard ratios of ST-T abnormalities with left high R waves for CVD mortality were 1.95 (95% confidence interval 1.25 to 3.04) in men and 2.68 (95% confidence interval 1.81 to 3.97) in women. Isolated ST-T abnormalities increased the risk for CVD death by 1.66 times (95% confidence interval 1.01 to 2.71) in men and 1.62 times (95% confidence interval 1.18 to 2.24) in women. Association of ECG abnormalities with CVD mortality was independent of age, body mass index, systolic blood pressure, serum cholesterol, blood glucose, smoking and drinking, and antihypertensive medication. In conclusion, ST-T abnormalities with or without left high R waves on electrocardiogram recorded at rest constitute an independent predictor of CVD mortality in Japanese men and women.
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U2 - 10.1016/j.amjcard.2011.02.335
DO - 10.1016/j.amjcard.2011.02.335
M3 - Article
C2 - 21497783
AN - SCOPUS:79957952562
VL - 107
SP - 1718
EP - 1724
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 12
ER -