Progress in myocardial regeneration and cell transplantation

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Embryonic stem cells and bone marrow mesenchymal stem cells can be induced to differentiate into cardiomyocytes. Techniques to purify and transplant regenerated cardiomyocytes have been developed, and transplanted regenerated cardiomyocytes are capable of residing in the heart of recipients for long periods. Advances in tissue engineering technology have enabled the production of cardiomyocyte cell sheets for transplantation treatment of heart failure, without the need for a donor, and this has now reached the preclinical stage. The treatment of heart failure using cytokines to mobilize stem cells has also been explored.

Original languageEnglish
Pages (from-to)1431-1446
Number of pages16
JournalCirculation Journal
Volume69
Issue number12
DOIs
Publication statusPublished - 2005 Dec

Fingerprint

Cell Transplantation
Cardiac Myocytes
Regeneration
Treatment Failure
Heart Failure
Tissue Engineering
Embryonic Stem Cells
Mesenchymal Stromal Cells
Stem Cells
Bone Marrow
Cytokines
Technology
Transplants

Keywords

  • Bone marrow mesenchymal stem cells
  • Cardiomyocytes
  • Cell transplantation
  • Embryonic stem cells
  • Heart failure
  • Regenerative medicine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Progress in myocardial regeneration and cell transplantation. / Fukuda, Keiichi.

In: Circulation Journal, Vol. 69, No. 12, 12.2005, p. 1431-1446.

Research output: Contribution to journalArticle

@article{6e23f9209f5f4aab8d05aa7706caa249,
title = "Progress in myocardial regeneration and cell transplantation",
abstract = "Embryonic stem cells and bone marrow mesenchymal stem cells can be induced to differentiate into cardiomyocytes. Techniques to purify and transplant regenerated cardiomyocytes have been developed, and transplanted regenerated cardiomyocytes are capable of residing in the heart of recipients for long periods. Advances in tissue engineering technology have enabled the production of cardiomyocyte cell sheets for transplantation treatment of heart failure, without the need for a donor, and this has now reached the preclinical stage. The treatment of heart failure using cytokines to mobilize stem cells has also been explored.",
keywords = "Bone marrow mesenchymal stem cells, Cardiomyocytes, Cell transplantation, Embryonic stem cells, Heart failure, Regenerative medicine",
author = "Keiichi Fukuda",
year = "2005",
month = "12",
doi = "10.1253/circj.69.1431",
language = "English",
volume = "69",
pages = "1431--1446",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "12",

}

TY - JOUR

T1 - Progress in myocardial regeneration and cell transplantation

AU - Fukuda, Keiichi

PY - 2005/12

Y1 - 2005/12

N2 - Embryonic stem cells and bone marrow mesenchymal stem cells can be induced to differentiate into cardiomyocytes. Techniques to purify and transplant regenerated cardiomyocytes have been developed, and transplanted regenerated cardiomyocytes are capable of residing in the heart of recipients for long periods. Advances in tissue engineering technology have enabled the production of cardiomyocyte cell sheets for transplantation treatment of heart failure, without the need for a donor, and this has now reached the preclinical stage. The treatment of heart failure using cytokines to mobilize stem cells has also been explored.

AB - Embryonic stem cells and bone marrow mesenchymal stem cells can be induced to differentiate into cardiomyocytes. Techniques to purify and transplant regenerated cardiomyocytes have been developed, and transplanted regenerated cardiomyocytes are capable of residing in the heart of recipients for long periods. Advances in tissue engineering technology have enabled the production of cardiomyocyte cell sheets for transplantation treatment of heart failure, without the need for a donor, and this has now reached the preclinical stage. The treatment of heart failure using cytokines to mobilize stem cells has also been explored.

KW - Bone marrow mesenchymal stem cells

KW - Cardiomyocytes

KW - Cell transplantation

KW - Embryonic stem cells

KW - Heart failure

KW - Regenerative medicine

UR - http://www.scopus.com/inward/record.url?scp=28544453391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28544453391&partnerID=8YFLogxK

U2 - 10.1253/circj.69.1431

DO - 10.1253/circj.69.1431

M3 - Article

C2 - 16308489

AN - SCOPUS:28544453391

VL - 69

SP - 1431

EP - 1446

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 12

ER -