Progress of research in osteoarthritis. Metalloproteinases in osteoarthritis

Aiko Okada, Yasunori Okada

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by destruction of articular cartilage induced by accumulated mechanical stresses to joints. Destruction of the articular cartilage in OA is caused by the combination of (1) increased degradation of ECM (extracellular matrix), (2) decreased production of ECM and (3) chondrocyte death. Members of the MMP (matrix metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene families are considered to play key roles in the degradation of cartilage ECM. On the other hand, members of the membrane-type ADAM gene family may be involved in the initiation and progression of OA by regulation of chondrocyte metabolism through shedding of membrane proteins.

Original languageEnglish
Pages (from-to)1593-1601
Number of pages9
JournalClinical calcium
Volume19
Issue number11
Publication statusPublished - 2009 Nov

Fingerprint

Metalloproteases
Osteoarthritis
Extracellular Matrix
Articular Cartilage
Chondrocytes
Research
Thrombospondins
Disintegrins
Mechanical Stress
Matrix Metalloproteinases
Genes
Cartilage
Membrane Proteins
Joints
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Progress of research in osteoarthritis. Metalloproteinases in osteoarthritis. / Okada, Aiko; Okada, Yasunori.

In: Clinical calcium, Vol. 19, No. 11, 11.2009, p. 1593-1601.

Research output: Contribution to journalArticle

Okada, A & Okada, Y 2009, 'Progress of research in osteoarthritis. Metalloproteinases in osteoarthritis', Clinical calcium, vol. 19, no. 11, pp. 1593-1601.
Okada, Aiko ; Okada, Yasunori. / Progress of research in osteoarthritis. Metalloproteinases in osteoarthritis. In: Clinical calcium. 2009 ; Vol. 19, No. 11. pp. 1593-1601.
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