Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study

Status at February 2004

Keiko Hosohata, Shin Saito, Kei Asayama, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Taku Obara, Tetsuo Kato, Junichiro Hashimoto, Kazuhito Totsune, Yukio Miura, Yutaka Imai, Kikuo Arakawa, Masatoshi Fujishima, Jun Fujii, Koushiro Fukiyama, Shigeru Hisamichi, Osamu Iimura, Masao Ishii, Teruo Omae & 526 others Takao Saruta, Kaoru Yoshinaga, Isao Abe, Kouji Abe, Teruo Abukawa, Terunao Ashida, Nobutaka Dohba, Tanenao Etoh, Akio Fujimura, Toshiro Fujita, Akio Fukui, Toshikazu Gotoh, Hitoshi Hama, Takuzo Hano, Hiroshi Hayashi, Noriaki Hayashida, Masato Hayashi, Katsuhiko Hiramori, Yasunobu Hirai, Yukio Hirata, Kunio Hiwada, Kazuhito Hora, Shuichi Ichikawa, Toshiho Iida, Toshio Ikeda, Tsutomu Imaizumi, Kinji Ishikawa, Ichisuke Ito, Masaaki Ito, Sadayoshi Ito, Daisuke Iwaoka, Ken Kanamasa, Takashi Katagiri, Shigehiro Katayama, Hiroshi Kawamura, Yuhei Kawano, Hiroshi Kida, Kenjiro Kikuchi, Genjiro Kimura, Kenjiro Kimura, Hiroshi Kitaoka, Shoutai Kobayashi, Katsuhiko Kohara, Shunichi Kojima, Issei Komuro, Hiroo Kumagai, Yuji Kumagai, Eiji Kusano, Toshio Kushiro, Iwao Kuwajima, Yukio Maruyama, Fumiaki Masani, Hiroaki Matsubara, Tatsuaki Matsubara, Masayasu Matsumoto, Hiroaki Matsuoka, Hideo Matsuura, Yasuo Mishima, Mamoru Miura, Isamu Miyamori, Hideki Mori, Hidenori Murakami, Hiromi Muratani, Motoya Nakagawa, Kazuwa Nakao, Mitsuhide Naruse, Ichiro Nishio, Toshio Ogihara, Masahiro Ohta, Kuniaki Ohtsuka, Youichi Ohtsuka, Yasuyoshi Ohuchi, Shinichi Oikawa, Masaaki Okabe, Ken Okumura, Ikuo Saitoh, Hisao Saitoh, Toshiie Sakata, Keijiro Saku, Hidetada Sasaki, Masahide Seino, Shouichi Senda, Kazuyuki Shimada, Kazuaki Shimamoto, Mitsuyuki Shimizu, Toshiaki Shiomi, Kunio Shirato, Masayoshi Sone, Hiromichi Suzuki, Shin Suzuki, Hakuo Takahashi, Masanobu Takada, Kazuo Takeda, Noriyuki Takeda, Akira Takeshita, Shuichi Takishita, Shigemichi Tanaka, Kenji Toba, Osamu Tochikubo, Hitonobu Tomoike, Yuji Ueno, Satoshi Umemura, Hidenori Urata, Takeshi Watanabe, Kenichi Yamada, Tohru Yamaguchi, Minoru Yamakado, Yasumasa Yamamoto, Yoshiharu Yamamoto, Akira Yamashina, Hitoshi Yokoyama, Manabu Yoshimura, Hiroshi Satoh, Yoshitomo Oka, Hideki Katagiri, Yoshiaki Kondo, Hisayasu Shishido, Akiko Kohinata, Yohko Kanno, Hiroko Ikeda, Yuri Takahira, Takahito Takahashi, Atsushi Kimura, Jin Funahashi, Noriko Takada, Tomohiro Hanazawa, Naoko Suzuki, Motoko Osugi, Juinichiro Hashimoto, Y. Ogawa, T. Miyamura, Y. Masuda, S. Tanaka, S. Tanaka, M. Koizumi, T. Ando, T. Endo, A. Tsuchida, M. Nanba, S. Yonekura, M. Shiroishi, M. Nakagawa, K. Ito, K. Oda, K. Takahashi, I. Kanahara, N. Hirota, M. Tsutsui, J. Anzai, S. Hosoda, M. Shiiki, Y. Takagawa, M. Iida, M. Tada, T. Noto, H. Tanaka, G. Tajima, K. Kawamorita, K. Kikuchi, H. Suzuki, K. Suzuki, K. Komai, H. Seki, A. Omoto, H. Takahashi, A. Kitabayashi, M. Kimura, Y. Kimura, H. Yamamoto, K. Takahashi, H. Kimura, Y. Kawamorita, Y. Emura, Y. Suzuki, Y. Ishikawa, K. Nagai, S. Nagai, T. Ito, K. Nihei, S. Yamada, T. Goto, N. Yamamoto, Y. Suzuki, H. Ito, M. Ito, T. Fujita, Y. Tominaga, S. Tominaga, K. Suzuki, K. Ishibashi, Y. Ando, S. Sato, H. Morikawa, S. Kashima, D. Nakayama, Y. Hayashi, K. Ohta, H. Metoki, K. Fukami, T. Hayashi, M. Kishi, J. Tajima, J. Seino, H. Hoshi, Y. Imai, H. Kimura, R. Mori, K. Matsuo, Y. Tanno, A. Shibasaki, T. Yamagishi, E. Ohtomo, Y. Ohtsuka, S. Sasaki, M. Seino, K. Kurosawa, K. Ito, Y. Takagi, S. Kyogoku, K. Ito, Y. Ono, M. Watanabe, S. Watanabe, N. Hiwatashi, C. Yagi, H. Unakami, K. Asayama, T. Mouri, T. Watanabe, K. Kikuchi, N. Maruyama, M. Sone, M. Iwamoto, S. Naganuma, H. Mashiko, H. Ishii, Y. Takaya, M. Kamimoto, A. Shirai, R. Watanabe, Y. Tohyama, F. Araki, H. Sakuma, Y. Amada, E. Sato, M. Techigawara, K. Nakamura, T. Nakayama, Kazuhiro Hasegawa, K. Hasegawa, T. Nagao, J. Minami, Y. Kumagai, T. Cho, K. Okamoto, T. Iguchi, T. Honzawa, T. Koitabashi, T. Yamada, H. Horikoshi, T. Nagao, H. Yoshimatsu, K. Seki, N. Akiyama, H. Suga, R. Matsunaga, T. Sinozaki, Y. Ishimaru, N. Yagi, H. Takikawa, T. Hukutome, C. Nakajima, H. Sato, J. Simizu, M. Arai, H. Koide, H. Takada, T. Sato, T. Umezu, H. Aoki, H. Nakamoto, K. Komahashi, S. Sekiya, H. Sugimoto, T. Arai, H. Suzuki, S. Inokuma, T. Funazaki, F. Yasuda, S. Kanouzawa, C. Yokota, Y. Noguchi, M. Hatano, T. Izumida, T. Hara, H. Muranaka, M. Suzuki, Y. Ogawa, E. Yabumoto, S. Matsushita, K. Kohzu, F. Sasaki, N. Hata, M. Yanagisawa, T. Ueda, M. Kurosawa, S. Doutare, S. Higashi, M. Kato, T. Hoshino, K. Fukuda, K. Ohtsuki, T. Ikeda, T. Kasatani, T. Yamada, S. Yatagai, E. Ohsuga, M. Yamakado, H. Kawamura, H. Mitsubayashi, S. Yamashina, J. Yamazaki, S. Nanjo, S. Ito, T. Teramoto, T. Gomi, S. Kato, N. Koekawa, K. Kuwaki, T. Ikeda, K. Hori, S. Arai, H. Koyama, M. Ichikawa, A. Hashimoto, H. Mori, S. Abe, Y. Ohba, F. Kurata, M. Miyakawa, K. Kimura, Y. Hatori, M. Ushiyama, H. Yamamoto, M. Adachi, K. Takayama, M. Shimizu, T. Iida, S. Asato, K. Uchiba, N. Watanabe, M. Kotani, F. Akaoka, S. Takahashi, K. Hirahara, S. Suzuki, Y. Yamaguchi, S. Ishikawa, K. Sasaki, Y. Terada, S. Ohhashi, A. Sakamaki, N. Hifumi, T. Ohno, T. Saeki, Y. Suzaki, H. Yamamoto, T. Nakagawa, F. Tomoda, H. Nishino, T. Ise, H. Takakuwa, H. Yokoyama, S. Kitakawa, K. Takasawa, T. Ohkura, Y. Yamamoto, K. Satake, Y. Arai, H. Nakayama, S. Sugiyama, K. Sugiura, M. Yokoyama, A. Ito, K. Okazaki, R. Saito, J. Mihara, A. Naito, Y. Takahira, T. Mori, M. Watanabe, S. Asai, O. Nojiri, K. Sakakura, M. Kozuka, Y. Oyama, Y. Kawamura, T. Inoko, N. Takeuchi, H. Tatematsu, Y. Hayakawa, N. Adachi, N. Tamagaki, T. Nakamura, A. Fukui, M. Amenomori, T. Kanaya, A. Masui, K. Hayashi, S. Nishi, M. Amari, K. Yoshida, Y. Matsushita, S. Sawada, M. Fujiwara, S. Ono, K. Tamai, Y. Takemoto, T. Kanemasa, T. Takenaka, K. Kitayama, K. Yasui, S. Fujita, Y. Terayama, N. Kato, M. Nagai, H. Takashima, K. Watanabe, N. Hirobe, M. Miyamoto, N. Sakamoto, Y. Kurimoto, N. Suzuki, S. Katsuya, T. Katsuya, K. Nagao, K. Nakamuta, S. Goto, T. Ueda, N. Imai, I. Sano, H. Ueda, N. Takahashi, T. Sada, M. Iwane, H. Suzuki, H. Yoshikawa, Y. Tominaga, M. Kamura, A. Ohtahara, Y. Nakamura, M. Osakada, M. Gen, M. Kahara, T. Yoshimoto, K. Mizuno, Y. Furukawa, A. Tokunaga, N. Sasaki, M. Matsumura, T. Furue, K. Iwasaki, K. Ichiki, S. Mizofuchi, T. Yokoi, W. Furumoto, T. Fukui, K. Fujino, A. Ohta, S. Ueda, Y. Kitami, T. Ohkura, M. Takeuchi, K. Yoshida, S. Nishiyama, R. Kawamoto, A. Kobaru, T. Endo, K. Kitano, Y. Hirooka, M. Tohaya, Y. Miyazaki, K. Onoyama, J. Miyagi, U. Kin, Y. Fujishima, A. Kuwahara, R. Shindo, Y. Satake, T. Moritsuka, T. Kuwahara, O. Hano, Y. Takagi, S. Suzuki, K. Abe, T. Sato, M. Kohno, T. Fujino, K. Wakayama, T. Aso, T. Goto, H. Ozaki, K. Ninomiya, Y. Inobe, S. Hamasaki, J. Inoue, S. Naomi, T. Iwaoka, T. Ono, Y. Muta, Y. Endo, H. Ohmori, M. Nagata, N. Wake, H. Kozawa, Y. Tomino, T. Ikeda, H. Yoshii, H. Nakamura, N. Fujimoto, T. Asato, M. Tozawa, R. Sunagawa, Y. Nakamura, H. Tomori, K. Takashiba

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) Study is the first large-scale intervention trial in Japan using a PROBE design to determine an optimal target blood pressure (BP) level on the basis of self-measured BP at home and optimal initial antihypertensive medication. The registered patients are randomized to one of two different BP levels and to initial antihypertensive regimens (i.e., calcium antagonist [Ca-A], angiotensin-converting enzyme inhibitor [ACE-I], or angiotensin II receptor antagonist [ARB]).At the end of February 2004, 2729, 1687, and 971 patients were recruited, randomized, and followed-up for 12 months or more. Among the 971 patients, mean systolic/diastolic BP levels at randomization in the Ca-A, ACE-I, and ARB groups were 150/90, 152/89, and 151/89 mmHg, respectively. These values reduced after six months of Ca-A-, ACE-I-, and ARB-based treatment (133/81 mmHg, 135/80 mmHg, and 134/79 mmHg, respectively) and further reduced after 12 months (131/80 mmHg, 134/79 mmHg, and 132/79 mmHg, respectively) without any significant differences among groups. In more intensive and less intensive BP-lowering groups, mean systolic/diastolic BP levels at randomization were 151/90 and 150/89 mmHg, respectively. Although BP levels reduced after 6-month (135/80 mmHg and 133/80 mmHg, respectively) and 12-month treatment (133/79 mmHg and 132/80 mmHg, respectively) in each target group, no significant difference in BP values was observed between groups. These results indicate the necessity of additional interventional strategies to improve the achievement of target BP levels, especially in the more intensive BP-lowering group.

Original languageEnglish
Pages (from-to)69-81
Number of pages13
JournalClinical and Experimental Hypertension
Volume29
Issue number1
DOIs
Publication statusPublished - 2007 Jan
Externally publishedYes

Fingerprint

Blood Pressure
Hypertension
Equipment and Supplies
Therapeutics
Angiotensin-Converting Enzyme Inhibitors
Random Allocation
Calcium
Antihypertensive Agents
Angiotensin Receptor Antagonists
Japan

Keywords

  • Blood pressure measurement at home
  • Hypertension
  • Internet
  • Prospective randomized open-label blinded-endpoint (PROBE)
  • Randomized controlled trial (RCT)

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study : Status at February 2004. / Hosohata, Keiko; Saito, Shin; Asayama, Kei; Ohkubo, Takayoshi; Kikuya, Masahiro; Metoki, Hirohito; Obara, Taku; Kato, Tetsuo; Hashimoto, Junichiro; Totsune, Kazuhito; Miura, Yukio; Imai, Yutaka; Arakawa, Kikuo; Fujishima, Masatoshi; Fujii, Jun; Fukiyama, Koushiro; Hisamichi, Shigeru; Iimura, Osamu; Ishii, Masao; Omae, Teruo; Saruta, Takao; Yoshinaga, Kaoru; Abe, Isao; Abe, Kouji; Abukawa, Teruo; Ashida, Terunao; Dohba, Nobutaka; Etoh, Tanenao; Fujimura, Akio; Fujita, Toshiro; Fukui, Akio; Gotoh, Toshikazu; Hama, Hitoshi; Hano, Takuzo; Hayashi, Hiroshi; Hayashida, Noriaki; Hayashi, Masato; Hiramori, Katsuhiko; Hirai, Yasunobu; Hirata, Yukio; Hiwada, Kunio; Hora, Kazuhito; Ichikawa, Shuichi; Iida, Toshiho; Ikeda, Toshio; Imaizumi, Tsutomu; Ishikawa, Kinji; Ito, Ichisuke; Ito, Masaaki; Ito, Sadayoshi; Iwaoka, Daisuke; Kanamasa, Ken; Katagiri, Takashi; Katayama, Shigehiro; Kawamura, Hiroshi; Kawano, Yuhei; Kida, Hiroshi; Kikuchi, Kenjiro; Kimura, Genjiro; Kimura, Kenjiro; Kitaoka, Hiroshi; Kobayashi, Shoutai; Kohara, Katsuhiko; Kojima, Shunichi; Komuro, Issei; Kumagai, Hiroo; Kumagai, Yuji; Kusano, Eiji; Kushiro, Toshio; Kuwajima, Iwao; Maruyama, Yukio; Masani, Fumiaki; Matsubara, Hiroaki; Matsubara, Tatsuaki; Matsumoto, Masayasu; Matsuoka, Hiroaki; Matsuura, Hideo; Mishima, Yasuo; Miura, Mamoru; Miyamori, Isamu; Mori, Hideki; Murakami, Hidenori; Muratani, Hiromi; Nakagawa, Motoya; Nakao, Kazuwa; Naruse, Mitsuhide; Nishio, Ichiro; Ogihara, Toshio; Ohta, Masahiro; Ohtsuka, Kuniaki; Ohtsuka, Youichi; Ohuchi, Yasuyoshi; Oikawa, Shinichi; Okabe, Masaaki; Okumura, Ken; Saitoh, Ikuo; Saitoh, Hisao; Sakata, Toshiie; Saku, Keijiro; Sasaki, Hidetada; Seino, Masahide; Senda, Shouichi; Shimada, Kazuyuki; Shimamoto, Kazuaki; Shimizu, Mitsuyuki; Shiomi, Toshiaki; Shirato, Kunio; Sone, Masayoshi; Suzuki, Hiromichi; Suzuki, Shin; Takahashi, Hakuo; Takada, Masanobu; Takeda, Kazuo; Takeda, Noriyuki; Takeshita, Akira; Takishita, Shuichi; Tanaka, Shigemichi; Toba, Kenji; Tochikubo, Osamu; Tomoike, Hitonobu; Ueno, Yuji; Umemura, Satoshi; Urata, Hidenori; Watanabe, Takeshi; Yamada, Kenichi; Yamaguchi, Tohru; Yamakado, Minoru; Yamamoto, Yasumasa; Yamamoto, Yoshiharu; Yamashina, Akira; Yokoyama, Hitoshi; Yoshimura, Manabu; Satoh, Hiroshi; Oka, Yoshitomo; Katagiri, Hideki; Kondo, Yoshiaki; Shishido, Hisayasu; Kohinata, Akiko; Kanno, Yohko; Ikeda, Hiroko; Takahira, Yuri; Takahashi, Takahito; Kimura, Atsushi; Funahashi, Jin; Takada, Noriko; Hanazawa, Tomohiro; Suzuki, Naoko; Osugi, Motoko; Hashimoto, Juinichiro; Ogawa, Y.; Miyamura, T.; Masuda, Y.; Tanaka, S.; Tanaka, S.; Koizumi, M.; Ando, T.; Endo, T.; Tsuchida, A.; Nanba, M.; Yonekura, S.; Shiroishi, M.; Nakagawa, M.; Ito, K.; Oda, K.; Takahashi, K.; Kanahara, I.; Hirota, N.; Tsutsui, M.; Anzai, J.; Hosoda, S.; Shiiki, M.; Takagawa, Y.; Iida, M.; Tada, M.; Noto, T.; Tanaka, H.; Tajima, G.; Kawamorita, K.; Kikuchi, K.; Suzuki, H.; Suzuki, K.; Komai, K.; Seki, H.; Omoto, A.; Takahashi, H.; Kitabayashi, A.; Kimura, M.; Kimura, Y.; Yamamoto, H.; Takahashi, K.; Kimura, H.; Kawamorita, Y.; Emura, Y.; Suzuki, Y.; Ishikawa, Y.; Nagai, K.; Nagai, S.; Ito, T.; Nihei, K.; Yamada, S.; Goto, T.; Yamamoto, N.; Suzuki, Y.; Ito, H.; Ito, M.; Fujita, T.; Tominaga, Y.; Tominaga, S.; Suzuki, K.; Ishibashi, K.; Ando, Y.; Sato, S.; Morikawa, H.; Kashima, S.; Nakayama, D.; Hayashi, Y.; Ohta, K.; Metoki, H.; Fukami, K.; Hayashi, T.; Kishi, M.; Tajima, J.; Seino, J.; Hoshi, H.; Imai, Y.; Kimura, H.; Mori, R.; Matsuo, K.; Tanno, Y.; Shibasaki, A.; Yamagishi, T.; Ohtomo, E.; Ohtsuka, Y.; Sasaki, S.; Seino, M.; Kurosawa, K.; Ito, K.; Takagi, Y.; Kyogoku, S.; Ito, K.; Ono, Y.; Watanabe, M.; Watanabe, S.; Hiwatashi, N.; Yagi, C.; Unakami, H.; Asayama, K.; Mouri, T.; Watanabe, T.; Kikuchi, K.; Maruyama, N.; Sone, M.; Iwamoto, M.; Naganuma, S.; Mashiko, H.; Ishii, H.; Takaya, Y.; Kamimoto, M.; Shirai, A.; Watanabe, R.; Tohyama, Y.; Araki, F.; Sakuma, H.; Amada, Y.; Sato, E.; Techigawara, M.; Nakamura, K.; Nakayama, T.; Hasegawa, Kazuhiro; Hasegawa, K.; Nagao, T.; Minami, J.; Kumagai, Y.; Cho, T.; Okamoto, K.; Iguchi, T.; Honzawa, T.; Koitabashi, T.; Yamada, T.; Horikoshi, H.; Nagao, T.; Yoshimatsu, H.; Seki, K.; Akiyama, N.; Suga, H.; Matsunaga, R.; Sinozaki, T.; Ishimaru, Y.; Yagi, N.; Takikawa, H.; Hukutome, T.; Nakajima, C.; Sato, H.; Simizu, J.; Arai, M.; Koide, H.; Takada, H.; Sato, T.; Umezu, T.; Aoki, H.; Nakamoto, H.; Komahashi, K.; Sekiya, S.; Sugimoto, H.; Arai, T.; Suzuki, H.; Inokuma, S.; Funazaki, T.; Yasuda, F.; Kanouzawa, S.; Yokota, C.; Noguchi, Y.; Hatano, M.; Izumida, T.; Hara, T.; Muranaka, H.; Suzuki, M.; Ogawa, Y.; Yabumoto, E.; Matsushita, S.; Kohzu, K.; Sasaki, F.; Hata, N.; Yanagisawa, M.; Ueda, T.; Kurosawa, M.; Doutare, S.; Higashi, S.; Kato, M.; Hoshino, T.; Fukuda, K.; Ohtsuki, K.; Ikeda, T.; Kasatani, T.; Yamada, T.; Yatagai, S.; Ohsuga, E.; Yamakado, M.; Kawamura, H.; Mitsubayashi, H.; Yamashina, S.; Yamazaki, J.; Nanjo, S.; Ito, S.; Teramoto, T.; Gomi, T.; Kato, S.; Koekawa, N.; Kuwaki, K.; Ikeda, T.; Hori, K.; Arai, S.; Koyama, H.; Ichikawa, M.; Hashimoto, A.; Mori, H.; Abe, S.; Ohba, Y.; Kurata, F.; Miyakawa, M.; Kimura, K.; Hatori, Y.; Ushiyama, M.; Yamamoto, H.; Adachi, M.; Takayama, K.; Shimizu, M.; Iida, T.; Asato, S.; Uchiba, K.; Watanabe, N.; Kotani, M.; Akaoka, F.; Takahashi, S.; Hirahara, K.; Suzuki, S.; Yamaguchi, Y.; Ishikawa, S.; Sasaki, K.; Terada, Y.; Ohhashi, S.; Sakamaki, A.; Hifumi, N.; Ohno, T.; Saeki, T.; Suzaki, Y.; Yamamoto, H.; Nakagawa, T.; Tomoda, F.; Nishino, H.; Ise, T.; Takakuwa, H.; Yokoyama, H.; Kitakawa, S.; Takasawa, K.; Ohkura, T.; Yamamoto, Y.; Satake, K.; Arai, Y.; Nakayama, H.; Sugiyama, S.; Sugiura, K.; Yokoyama, M.; Ito, A.; Okazaki, K.; Saito, R.; Mihara, J.; Naito, A.; Takahira, Y.; Mori, T.; Watanabe, M.; Asai, S.; Nojiri, O.; Sakakura, K.; Kozuka, M.; Oyama, Y.; Kawamura, Y.; Inoko, T.; Takeuchi, N.; Tatematsu, H.; Hayakawa, Y.; Adachi, N.; Tamagaki, N.; Nakamura, T.; Fukui, A.; Amenomori, M.; Kanaya, T.; Masui, A.; Hayashi, K.; Nishi, S.; Amari, M.; Yoshida, K.; Matsushita, Y.; Sawada, S.; Fujiwara, M.; Ono, S.; Tamai, K.; Takemoto, Y.; Kanemasa, T.; Takenaka, T.; Kitayama, K.; Yasui, K.; Fujita, S.; Terayama, Y.; Kato, N.; Nagai, M.; Takashima, H.; Watanabe, K.; Hirobe, N.; Miyamoto, M.; Sakamoto, N.; Kurimoto, Y.; Suzuki, N.; Katsuya, S.; Katsuya, T.; Nagao, K.; Nakamuta, K.; Goto, S.; Ueda, T.; Imai, N.; Sano, I.; Ueda, H.; Takahashi, N.; Sada, T.; Iwane, M.; Suzuki, H.; Yoshikawa, H.; Tominaga, Y.; Kamura, M.; Ohtahara, A.; Nakamura, Y.; Osakada, M.; Gen, M.; Kahara, M.; Yoshimoto, T.; Mizuno, K.; Furukawa, Y.; Tokunaga, A.; Sasaki, N.; Matsumura, M.; Furue, T.; Iwasaki, K.; Ichiki, K.; Mizofuchi, S.; Yokoi, T.; Furumoto, W.; Fukui, T.; Fujino, K.; Ohta, A.; Ueda, S.; Kitami, Y.; Ohkura, T.; Takeuchi, M.; Yoshida, K.; Nishiyama, S.; Kawamoto, R.; Kobaru, A.; Endo, T.; Kitano, K.; Hirooka, Y.; Tohaya, M.; Miyazaki, Y.; Onoyama, K.; Miyagi, J.; Kin, U.; Fujishima, Y.; Kuwahara, A.; Shindo, R.; Satake, Y.; Moritsuka, T.; Kuwahara, T.; Hano, O.; Takagi, Y.; Suzuki, S.; Abe, K.; Sato, T.; Kohno, M.; Fujino, T.; Wakayama, K.; Aso, T.; Goto, T.; Ozaki, H.; Ninomiya, K.; Inobe, Y.; Hamasaki, S.; Inoue, J.; Naomi, S.; Iwaoka, T.; Ono, T.; Muta, Y.; Endo, Y.; Ohmori, H.; Nagata, M.; Wake, N.; Kozawa, H.; Tomino, Y.; Ikeda, T.; Yoshii, H.; Nakamura, H.; Fujimoto, N.; Asato, T.; Tozawa, M.; Sunagawa, R.; Nakamura, Y.; Tomori, H.; Takashiba, K.

In: Clinical and Experimental Hypertension, Vol. 29, No. 1, 01.2007, p. 69-81.

Research output: Contribution to journalArticle

Hosohata, K, Saito, S, Asayama, K, Ohkubo, T, Kikuya, M, Metoki, H, Obara, T, Kato, T, Hashimoto, J, Totsune, K, Miura, Y, Imai, Y, Arakawa, K, Fujishima, M, Fujii, J, Fukiyama, K, Hisamichi, S, Iimura, O, Ishii, M, Omae, T, Saruta, T, Yoshinaga, K, Abe, I, Abe, K, Abukawa, T, Ashida, T, Dohba, N, Etoh, T, Fujimura, A, Fujita, T, Fukui, A, Gotoh, T, Hama, H, Hano, T, Hayashi, H, Hayashida, N, Hayashi, M, Hiramori, K, Hirai, Y, Hirata, Y, Hiwada, K, Hora, K, Ichikawa, S, Iida, T, Ikeda, T, Imaizumi, T, Ishikawa, K, Ito, I, Ito, M, Ito, S, Iwaoka, D, Kanamasa, K, Katagiri, T, Katayama, S, Kawamura, H, Kawano, Y, Kida, H, Kikuchi, K, Kimura, G, Kimura, K, Kitaoka, H, Kobayashi, S, Kohara, K, Kojima, S, Komuro, I, Kumagai, H, Kumagai, Y, Kusano, E, Kushiro, T, Kuwajima, I, Maruyama, Y, Masani, F, Matsubara, H, Matsubara, T, Matsumoto, M, Matsuoka, H, Matsuura, H, Mishima, Y, Miura, M, Miyamori, I, Mori, H, Murakami, H, Muratani, H, Nakagawa, M, Nakao, K, Naruse, M, Nishio, I, Ogihara, T, Ohta, M, Ohtsuka, K, Ohtsuka, Y, Ohuchi, Y, Oikawa, S, Okabe, M, Okumura, K, Saitoh, I, Saitoh, H, Sakata, T, Saku, K, Sasaki, H, Seino, M, Senda, S, Shimada, K, Shimamoto, K, Shimizu, M, Shiomi, T, Shirato, K, Sone, M, Suzuki, H, Suzuki, S, Takahashi, H, Takada, M, Takeda, K, Takeda, N, Takeshita, A, Takishita, S, Tanaka, S, Toba, K, Tochikubo, O, Tomoike, H, Ueno, Y, Umemura, S, Urata, H, Watanabe, T, Yamada, K, Yamaguchi, T, Yamakado, M, Yamamoto, Y, Yamamoto, Y, Yamashina, A, Yokoyama, H, Yoshimura, M, Satoh, H, Oka, Y, Katagiri, H, Kondo, Y, Shishido, H, Kohinata, A, Kanno, Y, Ikeda, H, Takahira, Y, Takahashi, T, Kimura, A, Funahashi, J, Takada, N, Hanazawa, T, Suzuki, N, Osugi, M, Hashimoto, J, Ogawa, Y, Miyamura, T, Masuda, Y, Tanaka, S, Tanaka, S, Koizumi, M, Ando, T, Endo, T, Tsuchida, A, Nanba, M, Yonekura, S, Shiroishi, M, Nakagawa, M, Ito, K, Oda, K, Takahashi, K, Kanahara, I, Hirota, N, Tsutsui, M, Anzai, J, Hosoda, S, Shiiki, M, Takagawa, Y, Iida, M, Tada, M, Noto, T, Tanaka, H, Tajima, G, Kawamorita, K, Kikuchi, K, Suzuki, H, Suzuki, K, Komai, K, Seki, H, Omoto, A, Takahashi, H, Kitabayashi, A, Kimura, M, Kimura, Y, Yamamoto, H, Takahashi, K, Kimura, H, Kawamorita, Y, Emura, Y, Suzuki, Y, Ishikawa, Y, Nagai, K, Nagai, S, Ito, T, Nihei, K, Yamada, S, Goto, T, Yamamoto, N, Suzuki, Y, Ito, H, Ito, M, Fujita, T, Tominaga, Y, Tominaga, S, Suzuki, K, Ishibashi, K, Ando, Y, Sato, S, Morikawa, H, Kashima, S, Nakayama, D, Hayashi, Y, Ohta, K, Metoki, H, Fukami, K, Hayashi, T, Kishi, M, Tajima, J, Seino, J, Hoshi, H, Imai, Y, Kimura, H, Mori, R, Matsuo, K, Tanno, Y, Shibasaki, A, Yamagishi, T, Ohtomo, E, Ohtsuka, Y, Sasaki, S, Seino, M, Kurosawa, K, Ito, K, Takagi, Y, Kyogoku, S, Ito, K, Ono, Y, Watanabe, M, Watanabe, S, Hiwatashi, N, Yagi, C, Unakami, H, Asayama, K, Mouri, T, Watanabe, T, Kikuchi, K, Maruyama, N, Sone, M, Iwamoto, M, Naganuma, S, Mashiko, H, Ishii, H, Takaya, Y, Kamimoto, M, Shirai, A, Watanabe, R, Tohyama, Y, Araki, F, Sakuma, H, Amada, Y, Sato, E, Techigawara, M, Nakamura, K, Nakayama, T, Hasegawa, K, Hasegawa, K, Nagao, T, Minami, J, Kumagai, Y, Cho, T, Okamoto, K, Iguchi, T, Honzawa, T, Koitabashi, T, Yamada, T, Horikoshi, H, Nagao, T, Yoshimatsu, H, Seki, K, Akiyama, N, Suga, H, Matsunaga, R, Sinozaki, T, Ishimaru, Y, Yagi, N, Takikawa, H, Hukutome, T, Nakajima, C, Sato, H, Simizu, J, Arai, M, Koide, H, Takada, H, Sato, T, Umezu, T, Aoki, H, Nakamoto, H, Komahashi, K, Sekiya, S, Sugimoto, H, Arai, T, Suzuki, H, Inokuma, S, Funazaki, T, Yasuda, F, Kanouzawa, S, Yokota, C, Noguchi, Y, Hatano, M, Izumida, T, Hara, T, Muranaka, H, Suzuki, M, Ogawa, Y, Yabumoto, E, Matsushita, S, Kohzu, K, Sasaki, F, Hata, N, Yanagisawa, M, Ueda, T, Kurosawa, M, Doutare, S, Higashi, S, Kato, M, Hoshino, T, Fukuda, K, Ohtsuki, K, Ikeda, T, Kasatani, T, Yamada, T, Yatagai, S, Ohsuga, E, Yamakado, M, Kawamura, H, Mitsubayashi, H, Yamashina, S, Yamazaki, J, Nanjo, S, Ito, S, Teramoto, T, Gomi, T, Kato, S, Koekawa, N, Kuwaki, K, Ikeda, T, Hori, K, Arai, S, Koyama, H, Ichikawa, M, Hashimoto, A, Mori, H, Abe, S, Ohba, Y, Kurata, F, Miyakawa, M, Kimura, K, Hatori, Y, Ushiyama, M, Yamamoto, H, Adachi, M, Takayama, K, Shimizu, M, Iida, T, Asato, S, Uchiba, K, Watanabe, N, Kotani, M, Akaoka, F, Takahashi, S, Hirahara, K, Suzuki, S, Yamaguchi, Y, Ishikawa, S, Sasaki, K, Terada, Y, Ohhashi, S, Sakamaki, A, Hifumi, N, Ohno, T, Saeki, T, Suzaki, Y, Yamamoto, H, Nakagawa, T, Tomoda, F, Nishino, H, Ise, T, Takakuwa, H, Yokoyama, H, Kitakawa, S, Takasawa, K, Ohkura, T, Yamamoto, Y, Satake, K, Arai, Y, Nakayama, H, Sugiyama, S, Sugiura, K, Yokoyama, M, Ito, A, Okazaki, K, Saito, R, Mihara, J, Naito, A, Takahira, Y, Mori, T, Watanabe, M, Asai, S, Nojiri, O, Sakakura, K, Kozuka, M, Oyama, Y, Kawamura, Y, Inoko, T, Takeuchi, N, Tatematsu, H, Hayakawa, Y, Adachi, N, Tamagaki, N, Nakamura, T, Fukui, A, Amenomori, M, Kanaya, T, Masui, A, Hayashi, K, Nishi, S, Amari, M, Yoshida, K, Matsushita, Y, Sawada, S, Fujiwara, M, Ono, S, Tamai, K, Takemoto, Y, Kanemasa, T, Takenaka, T, Kitayama, K, Yasui, K, Fujita, S, Terayama, Y, Kato, N, Nagai, M, Takashima, H, Watanabe, K, Hirobe, N, Miyamoto, M, Sakamoto, N, Kurimoto, Y, Suzuki, N, Katsuya, S, Katsuya, T, Nagao, K, Nakamuta, K, Goto, S, Ueda, T, Imai, N, Sano, I, Ueda, H, Takahashi, N, Sada, T, Iwane, M, Suzuki, H, Yoshikawa, H, Tominaga, Y, Kamura, M, Ohtahara, A, Nakamura, Y, Osakada, M, Gen, M, Kahara, M, Yoshimoto, T, Mizuno, K, Furukawa, Y, Tokunaga, A, Sasaki, N, Matsumura, M, Furue, T, Iwasaki, K, Ichiki, K, Mizofuchi, S, Yokoi, T, Furumoto, W, Fukui, T, Fujino, K, Ohta, A, Ueda, S, Kitami, Y, Ohkura, T, Takeuchi, M, Yoshida, K, Nishiyama, S, Kawamoto, R, Kobaru, A, Endo, T, Kitano, K, Hirooka, Y, Tohaya, M, Miyazaki, Y, Onoyama, K, Miyagi, J, Kin, U, Fujishima, Y, Kuwahara, A, Shindo, R, Satake, Y, Moritsuka, T, Kuwahara, T, Hano, O, Takagi, Y, Suzuki, S, Abe, K, Sato, T, Kohno, M, Fujino, T, Wakayama, K, Aso, T, Goto, T, Ozaki, H, Ninomiya, K, Inobe, Y, Hamasaki, S, Inoue, J, Naomi, S, Iwaoka, T, Ono, T, Muta, Y, Endo, Y, Ohmori, H, Nagata, M, Wake, N, Kozawa, H, Tomino, Y, Ikeda, T, Yoshii, H, Nakamura, H, Fujimoto, N, Asato, T, Tozawa, M, Sunagawa, R, Nakamura, Y, Tomori, H & Takashiba, K 2007, 'Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study: Status at February 2004', Clinical and Experimental Hypertension, vol. 29, no. 1, pp. 69-81. https://doi.org/10.1080/10641960601096976
Hosohata, Keiko ; Saito, Shin ; Asayama, Kei ; Ohkubo, Takayoshi ; Kikuya, Masahiro ; Metoki, Hirohito ; Obara, Taku ; Kato, Tetsuo ; Hashimoto, Junichiro ; Totsune, Kazuhito ; Miura, Yukio ; Imai, Yutaka ; Arakawa, Kikuo ; Fujishima, Masatoshi ; Fujii, Jun ; Fukiyama, Koushiro ; Hisamichi, Shigeru ; Iimura, Osamu ; Ishii, Masao ; Omae, Teruo ; Saruta, Takao ; Yoshinaga, Kaoru ; Abe, Isao ; Abe, Kouji ; Abukawa, Teruo ; Ashida, Terunao ; Dohba, Nobutaka ; Etoh, Tanenao ; Fujimura, Akio ; Fujita, Toshiro ; Fukui, Akio ; Gotoh, Toshikazu ; Hama, Hitoshi ; Hano, Takuzo ; Hayashi, Hiroshi ; Hayashida, Noriaki ; Hayashi, Masato ; Hiramori, Katsuhiko ; Hirai, Yasunobu ; Hirata, Yukio ; Hiwada, Kunio ; Hora, Kazuhito ; Ichikawa, Shuichi ; Iida, Toshiho ; Ikeda, Toshio ; Imaizumi, Tsutomu ; Ishikawa, Kinji ; Ito, Ichisuke ; Ito, Masaaki ; Ito, Sadayoshi ; Iwaoka, Daisuke ; Kanamasa, Ken ; Katagiri, Takashi ; Katayama, Shigehiro ; Kawamura, Hiroshi ; Kawano, Yuhei ; Kida, Hiroshi ; Kikuchi, Kenjiro ; Kimura, Genjiro ; Kimura, Kenjiro ; Kitaoka, Hiroshi ; Kobayashi, Shoutai ; Kohara, Katsuhiko ; Kojima, Shunichi ; Komuro, Issei ; Kumagai, Hiroo ; Kumagai, Yuji ; Kusano, Eiji ; Kushiro, Toshio ; Kuwajima, Iwao ; Maruyama, Yukio ; Masani, Fumiaki ; Matsubara, Hiroaki ; Matsubara, Tatsuaki ; Matsumoto, Masayasu ; Matsuoka, Hiroaki ; Matsuura, Hideo ; Mishima, Yasuo ; Miura, Mamoru ; Miyamori, Isamu ; Mori, Hideki ; Murakami, Hidenori ; Muratani, Hiromi ; Nakagawa, Motoya ; Nakao, Kazuwa ; Naruse, Mitsuhide ; Nishio, Ichiro ; Ogihara, Toshio ; Ohta, Masahiro ; Ohtsuka, Kuniaki ; Ohtsuka, Youichi ; Ohuchi, Yasuyoshi ; Oikawa, Shinichi ; Okabe, Masaaki ; Okumura, Ken ; Saitoh, Ikuo ; Saitoh, Hisao ; Sakata, Toshiie ; Saku, Keijiro ; Sasaki, Hidetada ; Seino, Masahide ; Senda, Shouichi ; Shimada, Kazuyuki ; Shimamoto, Kazuaki ; Shimizu, Mitsuyuki ; Shiomi, Toshiaki ; Shirato, Kunio ; Sone, Masayoshi ; Suzuki, Hiromichi ; Suzuki, Shin ; Takahashi, Hakuo ; Takada, Masanobu ; Takeda, Kazuo ; Takeda, Noriyuki ; Takeshita, Akira ; Takishita, Shuichi ; Tanaka, Shigemichi ; Toba, Kenji ; Tochikubo, Osamu ; Tomoike, Hitonobu ; Ueno, Yuji ; Umemura, Satoshi ; Urata, Hidenori ; Watanabe, Takeshi ; Yamada, Kenichi ; Yamaguchi, Tohru ; Yamakado, Minoru ; Yamamoto, Yasumasa ; Yamamoto, Yoshiharu ; Yamashina, Akira ; Yokoyama, Hitoshi ; Yoshimura, Manabu ; Satoh, Hiroshi ; Oka, Yoshitomo ; Katagiri, Hideki ; Kondo, Yoshiaki ; Shishido, Hisayasu ; Kohinata, Akiko ; Kanno, Yohko ; Ikeda, Hiroko ; Takahira, Yuri ; Takahashi, Takahito ; Kimura, Atsushi ; Funahashi, Jin ; Takada, Noriko ; Hanazawa, Tomohiro ; Suzuki, Naoko ; Osugi, Motoko ; Hashimoto, Juinichiro ; Ogawa, Y. ; Miyamura, T. ; Masuda, Y. ; Tanaka, S. ; Tanaka, S. ; Koizumi, M. ; Ando, T. ; Endo, T. ; Tsuchida, A. ; Nanba, M. ; Yonekura, S. ; Shiroishi, M. ; Nakagawa, M. ; Ito, K. ; Oda, K. ; Takahashi, K. ; Kanahara, I. ; Hirota, N. ; Tsutsui, M. ; Anzai, J. ; Hosoda, S. ; Shiiki, M. ; Takagawa, Y. ; Iida, M. ; Tada, M. ; Noto, T. ; Tanaka, H. ; Tajima, G. ; Kawamorita, K. ; Kikuchi, K. ; Suzuki, H. ; Suzuki, K. ; Komai, K. ; Seki, H. ; Omoto, A. ; Takahashi, H. ; Kitabayashi, A. ; Kimura, M. ; Kimura, Y. ; Yamamoto, H. ; Takahashi, K. ; Kimura, H. ; Kawamorita, Y. ; Emura, Y. ; Suzuki, Y. ; Ishikawa, Y. ; Nagai, K. ; Nagai, S. ; Ito, T. ; Nihei, K. ; Yamada, S. ; Goto, T. ; Yamamoto, N. ; Suzuki, Y. ; Ito, H. ; Ito, M. ; Fujita, T. ; Tominaga, Y. ; Tominaga, S. ; Suzuki, K. ; Ishibashi, K. ; Ando, Y. ; Sato, S. ; Morikawa, H. ; Kashima, S. ; Nakayama, D. ; Hayashi, Y. ; Ohta, K. ; Metoki, H. ; Fukami, K. ; Hayashi, T. ; Kishi, M. ; Tajima, J. ; Seino, J. ; Hoshi, H. ; Imai, Y. ; Kimura, H. ; Mori, R. ; Matsuo, K. ; Tanno, Y. ; Shibasaki, A. ; Yamagishi, T. ; Ohtomo, E. ; Ohtsuka, Y. ; Sasaki, S. ; Seino, M. ; Kurosawa, K. ; Ito, K. ; Takagi, Y. ; Kyogoku, S. ; Ito, K. ; Ono, Y. ; Watanabe, M. ; Watanabe, S. ; Hiwatashi, N. ; Yagi, C. ; Unakami, H. ; Asayama, K. ; Mouri, T. ; Watanabe, T. ; Kikuchi, K. ; Maruyama, N. ; Sone, M. ; Iwamoto, M. ; Naganuma, S. ; Mashiko, H. ; Ishii, H. ; Takaya, Y. ; Kamimoto, M. ; Shirai, A. ; Watanabe, R. ; Tohyama, Y. ; Araki, F. ; Sakuma, H. ; Amada, Y. ; Sato, E. ; Techigawara, M. ; Nakamura, K. ; Nakayama, T. ; Hasegawa, Kazuhiro ; Hasegawa, K. ; Nagao, T. ; Minami, J. ; Kumagai, Y. ; Cho, T. ; Okamoto, K. ; Iguchi, T. ; Honzawa, T. ; Koitabashi, T. ; Yamada, T. ; Horikoshi, H. ; Nagao, T. ; Yoshimatsu, H. ; Seki, K. ; Akiyama, N. ; Suga, H. ; Matsunaga, R. ; Sinozaki, T. ; Ishimaru, Y. ; Yagi, N. ; Takikawa, H. ; Hukutome, T. ; Nakajima, C. ; Sato, H. ; Simizu, J. ; Arai, M. ; Koide, H. ; Takada, H. ; Sato, T. ; Umezu, T. ; Aoki, H. ; Nakamoto, H. ; Komahashi, K. ; Sekiya, S. ; Sugimoto, H. ; Arai, T. ; Suzuki, H. ; Inokuma, S. ; Funazaki, T. ; Yasuda, F. ; Kanouzawa, S. ; Yokota, C. ; Noguchi, Y. ; Hatano, M. ; Izumida, T. ; Hara, T. ; Muranaka, H. ; Suzuki, M. ; Ogawa, Y. ; Yabumoto, E. ; Matsushita, S. ; Kohzu, K. ; Sasaki, F. ; Hata, N. ; Yanagisawa, M. ; Ueda, T. ; Kurosawa, M. ; Doutare, S. ; Higashi, S. ; Kato, M. ; Hoshino, T. ; Fukuda, K. ; Ohtsuki, K. ; Ikeda, T. ; Kasatani, T. ; Yamada, T. ; Yatagai, S. ; Ohsuga, E. ; Yamakado, M. ; Kawamura, H. ; Mitsubayashi, H. ; Yamashina, S. ; Yamazaki, J. ; Nanjo, S. ; Ito, S. ; Teramoto, T. ; Gomi, T. ; Kato, S. ; Koekawa, N. ; Kuwaki, K. ; Ikeda, T. ; Hori, K. ; Arai, S. ; Koyama, H. ; Ichikawa, M. ; Hashimoto, A. ; Mori, H. ; Abe, S. ; Ohba, Y. ; Kurata, F. ; Miyakawa, M. ; Kimura, K. ; Hatori, Y. ; Ushiyama, M. ; Yamamoto, H. ; Adachi, M. ; Takayama, K. ; Shimizu, M. ; Iida, T. ; Asato, S. ; Uchiba, K. ; Watanabe, N. ; Kotani, M. ; Akaoka, F. ; Takahashi, S. ; Hirahara, K. ; Suzuki, S. ; Yamaguchi, Y. ; Ishikawa, S. ; Sasaki, K. ; Terada, Y. ; Ohhashi, S. ; Sakamaki, A. ; Hifumi, N. ; Ohno, T. ; Saeki, T. ; Suzaki, Y. ; Yamamoto, H. ; Nakagawa, T. ; Tomoda, F. ; Nishino, H. ; Ise, T. ; Takakuwa, H. ; Yokoyama, H. ; Kitakawa, S. ; Takasawa, K. ; Ohkura, T. ; Yamamoto, Y. ; Satake, K. ; Arai, Y. ; Nakayama, H. ; Sugiyama, S. ; Sugiura, K. ; Yokoyama, M. ; Ito, A. ; Okazaki, K. ; Saito, R. ; Mihara, J. ; Naito, A. ; Takahira, Y. ; Mori, T. ; Watanabe, M. ; Asai, S. ; Nojiri, O. ; Sakakura, K. ; Kozuka, M. ; Oyama, Y. ; Kawamura, Y. ; Inoko, T. ; Takeuchi, N. ; Tatematsu, H. ; Hayakawa, Y. ; Adachi, N. ; Tamagaki, N. ; Nakamura, T. ; Fukui, A. ; Amenomori, M. ; Kanaya, T. ; Masui, A. ; Hayashi, K. ; Nishi, S. ; Amari, M. ; Yoshida, K. ; Matsushita, Y. ; Sawada, S. ; Fujiwara, M. ; Ono, S. ; Tamai, K. ; Takemoto, Y. ; Kanemasa, T. ; Takenaka, T. ; Kitayama, K. ; Yasui, K. ; Fujita, S. ; Terayama, Y. ; Kato, N. ; Nagai, M. ; Takashima, H. ; Watanabe, K. ; Hirobe, N. ; Miyamoto, M. ; Sakamoto, N. ; Kurimoto, Y. ; Suzuki, N. ; Katsuya, S. ; Katsuya, T. ; Nagao, K. ; Nakamuta, K. ; Goto, S. ; Ueda, T. ; Imai, N. ; Sano, I. ; Ueda, H. ; Takahashi, N. ; Sada, T. ; Iwane, M. ; Suzuki, H. ; Yoshikawa, H. ; Tominaga, Y. ; Kamura, M. ; Ohtahara, A. ; Nakamura, Y. ; Osakada, M. ; Gen, M. ; Kahara, M. ; Yoshimoto, T. ; Mizuno, K. ; Furukawa, Y. ; Tokunaga, A. ; Sasaki, N. ; Matsumura, M. ; Furue, T. ; Iwasaki, K. ; Ichiki, K. ; Mizofuchi, S. ; Yokoi, T. ; Furumoto, W. ; Fukui, T. ; Fujino, K. ; Ohta, A. ; Ueda, S. ; Kitami, Y. ; Ohkura, T. ; Takeuchi, M. ; Yoshida, K. ; Nishiyama, S. ; Kawamoto, R. ; Kobaru, A. ; Endo, T. ; Kitano, K. ; Hirooka, Y. ; Tohaya, M. ; Miyazaki, Y. ; Onoyama, K. ; Miyagi, J. ; Kin, U. ; Fujishima, Y. ; Kuwahara, A. ; Shindo, R. ; Satake, Y. ; Moritsuka, T. ; Kuwahara, T. ; Hano, O. ; Takagi, Y. ; Suzuki, S. ; Abe, K. ; Sato, T. ; Kohno, M. ; Fujino, T. ; Wakayama, K. ; Aso, T. ; Goto, T. ; Ozaki, H. ; Ninomiya, K. ; Inobe, Y. ; Hamasaki, S. ; Inoue, J. ; Naomi, S. ; Iwaoka, T. ; Ono, T. ; Muta, Y. ; Endo, Y. ; Ohmori, H. ; Nagata, M. ; Wake, N. ; Kozawa, H. ; Tomino, Y. ; Ikeda, T. ; Yoshii, H. ; Nakamura, H. ; Fujimoto, N. ; Asato, T. ; Tozawa, M. ; Sunagawa, R. ; Nakamura, Y. ; Tomori, H. ; Takashiba, K. / Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study : Status at February 2004. In: Clinical and Experimental Hypertension. 2007 ; Vol. 29, No. 1. pp. 69-81.
@article{a7e5822d36264d1589cbefccf1c0d471,
title = "Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study: Status at February 2004",
abstract = "The Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) Study is the first large-scale intervention trial in Japan using a PROBE design to determine an optimal target blood pressure (BP) level on the basis of self-measured BP at home and optimal initial antihypertensive medication. The registered patients are randomized to one of two different BP levels and to initial antihypertensive regimens (i.e., calcium antagonist [Ca-A], angiotensin-converting enzyme inhibitor [ACE-I], or angiotensin II receptor antagonist [ARB]).At the end of February 2004, 2729, 1687, and 971 patients were recruited, randomized, and followed-up for 12 months or more. Among the 971 patients, mean systolic/diastolic BP levels at randomization in the Ca-A, ACE-I, and ARB groups were 150/90, 152/89, and 151/89 mmHg, respectively. These values reduced after six months of Ca-A-, ACE-I-, and ARB-based treatment (133/81 mmHg, 135/80 mmHg, and 134/79 mmHg, respectively) and further reduced after 12 months (131/80 mmHg, 134/79 mmHg, and 132/79 mmHg, respectively) without any significant differences among groups. In more intensive and less intensive BP-lowering groups, mean systolic/diastolic BP levels at randomization were 151/90 and 150/89 mmHg, respectively. Although BP levels reduced after 6-month (135/80 mmHg and 133/80 mmHg, respectively) and 12-month treatment (133/79 mmHg and 132/80 mmHg, respectively) in each target group, no significant difference in BP values was observed between groups. These results indicate the necessity of additional interventional strategies to improve the achievement of target BP levels, especially in the more intensive BP-lowering group.",
keywords = "Blood pressure measurement at home, Hypertension, Internet, Prospective randomized open-label blinded-endpoint (PROBE), Randomized controlled trial (RCT)",
author = "Keiko Hosohata and Shin Saito and Kei Asayama and Takayoshi Ohkubo and Masahiro Kikuya and Hirohito Metoki and Taku Obara and Tetsuo Kato and Junichiro Hashimoto and Kazuhito Totsune and Yukio Miura and Yutaka Imai and Kikuo Arakawa and Masatoshi Fujishima and Jun Fujii and Koushiro Fukiyama and Shigeru Hisamichi and Osamu Iimura and Masao Ishii and Teruo Omae and Takao Saruta and Kaoru Yoshinaga and Isao Abe and Kouji Abe and Teruo Abukawa and Terunao Ashida and Nobutaka Dohba and Tanenao Etoh and Akio Fujimura and Toshiro Fujita and Akio Fukui and Toshikazu Gotoh and Hitoshi Hama and Takuzo Hano and Hiroshi Hayashi and Noriaki Hayashida and Masato Hayashi and Katsuhiko Hiramori and Yasunobu Hirai and Yukio Hirata and Kunio Hiwada and Kazuhito Hora and Shuichi Ichikawa and Toshiho Iida and Toshio Ikeda and Tsutomu Imaizumi and Kinji Ishikawa and Ichisuke Ito and Masaaki Ito and Sadayoshi Ito and Daisuke Iwaoka and Ken Kanamasa and Takashi Katagiri and Shigehiro Katayama and Hiroshi Kawamura and Yuhei Kawano and Hiroshi Kida and Kenjiro Kikuchi and Genjiro Kimura and Kenjiro Kimura and Hiroshi Kitaoka and Shoutai Kobayashi and Katsuhiko Kohara and Shunichi Kojima and Issei Komuro and Hiroo Kumagai and Yuji Kumagai and Eiji Kusano and Toshio Kushiro and Iwao Kuwajima and Yukio Maruyama and Fumiaki Masani and Hiroaki Matsubara and Tatsuaki Matsubara and Masayasu Matsumoto and Hiroaki Matsuoka and Hideo Matsuura and Yasuo Mishima and Mamoru Miura and Isamu Miyamori and Hideki Mori and Hidenori Murakami and Hiromi Muratani and Motoya Nakagawa and Kazuwa Nakao and Mitsuhide Naruse and Ichiro Nishio and Toshio Ogihara and Masahiro Ohta and Kuniaki Ohtsuka and Youichi Ohtsuka and Yasuyoshi Ohuchi and Shinichi Oikawa and Masaaki Okabe and Ken Okumura and Ikuo Saitoh and Hisao Saitoh and Toshiie Sakata and Keijiro Saku and Hidetada Sasaki and Masahide Seino and Shouichi Senda and Kazuyuki Shimada and Kazuaki Shimamoto and Mitsuyuki Shimizu and Toshiaki Shiomi and Kunio Shirato and Masayoshi Sone and Hiromichi Suzuki and Shin Suzuki and Hakuo Takahashi and Masanobu Takada and Kazuo Takeda and Noriyuki Takeda and Akira Takeshita and Shuichi Takishita and Shigemichi Tanaka and Kenji Toba and Osamu Tochikubo and Hitonobu Tomoike and Yuji Ueno and Satoshi Umemura and Hidenori Urata and Takeshi Watanabe and Kenichi Yamada and Tohru Yamaguchi and Minoru Yamakado and Yasumasa Yamamoto and Yoshiharu Yamamoto and Akira Yamashina and Hitoshi Yokoyama and Manabu Yoshimura and Hiroshi Satoh and Yoshitomo Oka and Hideki Katagiri and Yoshiaki Kondo and Hisayasu Shishido and Akiko Kohinata and Yohko Kanno and Hiroko Ikeda and Yuri Takahira and Takahito Takahashi and Atsushi Kimura and Jin Funahashi and Noriko Takada and Tomohiro Hanazawa and Naoko Suzuki and Motoko Osugi and Juinichiro Hashimoto and Y. Ogawa and T. Miyamura and Y. Masuda and S. Tanaka and S. Tanaka and M. Koizumi and T. Ando and T. Endo and A. Tsuchida and M. Nanba and S. Yonekura and M. Shiroishi and M. Nakagawa and K. Ito and K. Oda and K. Takahashi and I. Kanahara and N. Hirota and M. Tsutsui and J. Anzai and S. Hosoda and M. Shiiki and Y. Takagawa and M. Iida and M. Tada and T. Noto and H. Tanaka and G. Tajima and K. Kawamorita and K. Kikuchi and H. Suzuki and K. Suzuki and K. Komai and H. Seki and A. Omoto and H. Takahashi and A. Kitabayashi and M. Kimura and Y. Kimura and H. Yamamoto and K. Takahashi and H. Kimura and Y. Kawamorita and Y. Emura and Y. Suzuki and Y. Ishikawa and K. Nagai and S. Nagai and T. Ito and K. Nihei and S. Yamada and T. Goto and N. Yamamoto and Y. Suzuki and H. Ito and M. Ito and T. Fujita and Y. Tominaga and S. Tominaga and K. Suzuki and K. Ishibashi and Y. Ando and S. Sato and H. Morikawa and S. Kashima and D. Nakayama and Y. Hayashi and K. Ohta and H. Metoki and K. Fukami and T. Hayashi and M. Kishi and J. Tajima and J. Seino and H. Hoshi and Y. Imai and H. Kimura and R. Mori and K. Matsuo and Y. Tanno and A. Shibasaki and T. Yamagishi and E. Ohtomo and Y. Ohtsuka and S. Sasaki and M. Seino and K. Kurosawa and K. Ito and Y. Takagi and S. Kyogoku and K. Ito and Y. Ono and M. Watanabe and S. Watanabe and N. Hiwatashi and C. Yagi and H. Unakami and K. Asayama and T. Mouri and T. Watanabe and K. Kikuchi and N. Maruyama and M. Sone and M. Iwamoto and S. Naganuma and H. Mashiko and H. Ishii and Y. Takaya and M. Kamimoto and A. Shirai and R. Watanabe and Y. Tohyama and F. Araki and H. Sakuma and Y. Amada and E. Sato and M. Techigawara and K. Nakamura and T. Nakayama and Kazuhiro Hasegawa and K. Hasegawa and T. Nagao and J. Minami and Y. Kumagai and T. Cho and K. Okamoto and T. Iguchi and T. Honzawa and T. Koitabashi and T. Yamada and H. Horikoshi and T. Nagao and H. Yoshimatsu and K. Seki and N. Akiyama and H. Suga and R. Matsunaga and T. Sinozaki and Y. Ishimaru and N. Yagi and H. Takikawa and T. Hukutome and C. Nakajima and H. Sato and J. Simizu and M. Arai and H. Koide and H. Takada and T. Sato and T. Umezu and H. Aoki and H. Nakamoto and K. Komahashi and S. Sekiya and H. Sugimoto and T. Arai and H. Suzuki and S. Inokuma and T. Funazaki and F. Yasuda and S. Kanouzawa and C. Yokota and Y. Noguchi and M. Hatano and T. Izumida and T. Hara and H. Muranaka and M. Suzuki and Y. Ogawa and E. Yabumoto and S. Matsushita and K. Kohzu and F. Sasaki and N. Hata and M. Yanagisawa and T. Ueda and M. Kurosawa and S. Doutare and S. Higashi and M. Kato and T. Hoshino and K. Fukuda and K. Ohtsuki and T. Ikeda and T. Kasatani and T. Yamada and S. Yatagai and E. Ohsuga and M. Yamakado and H. Kawamura and H. Mitsubayashi and S. Yamashina and J. Yamazaki and S. Nanjo and S. Ito and T. Teramoto and T. Gomi and S. Kato and N. Koekawa and K. Kuwaki and T. Ikeda and K. Hori and S. Arai and H. Koyama and M. Ichikawa and A. Hashimoto and H. Mori and S. Abe and Y. Ohba and F. Kurata and M. Miyakawa and K. Kimura and Y. Hatori and M. Ushiyama and H. Yamamoto and M. Adachi and K. Takayama and M. Shimizu and T. Iida and S. Asato and K. Uchiba and N. Watanabe and M. Kotani and F. Akaoka and S. Takahashi and K. Hirahara and S. Suzuki and Y. Yamaguchi and S. Ishikawa and K. Sasaki and Y. Terada and S. Ohhashi and A. Sakamaki and N. Hifumi and T. Ohno and T. Saeki and Y. Suzaki and H. Yamamoto and T. Nakagawa and F. Tomoda and H. Nishino and T. Ise and H. Takakuwa and H. Yokoyama and S. Kitakawa and K. Takasawa and T. Ohkura and Y. Yamamoto and K. Satake and Y. Arai and H. Nakayama and S. Sugiyama and K. Sugiura and M. Yokoyama and A. Ito and K. Okazaki and R. Saito and J. Mihara and A. Naito and Y. Takahira and T. Mori and M. Watanabe and S. Asai and O. Nojiri and K. Sakakura and M. Kozuka and Y. Oyama and Y. Kawamura and T. Inoko and N. Takeuchi and H. Tatematsu and Y. Hayakawa and N. Adachi and N. Tamagaki and T. Nakamura and A. Fukui and M. Amenomori and T. Kanaya and A. Masui and K. Hayashi and S. Nishi and M. Amari and K. Yoshida and Y. Matsushita and S. Sawada and M. Fujiwara and S. Ono and K. Tamai and Y. Takemoto and T. Kanemasa and T. Takenaka and K. Kitayama and K. Yasui and S. Fujita and Y. Terayama and N. Kato and M. Nagai and H. Takashima and K. Watanabe and N. Hirobe and M. Miyamoto and N. Sakamoto and Y. Kurimoto and N. Suzuki and S. Katsuya and T. Katsuya and K. Nagao and K. Nakamuta and S. Goto and T. Ueda and N. Imai and I. Sano and H. Ueda and N. Takahashi and T. Sada and M. Iwane and H. Suzuki and H. Yoshikawa and Y. Tominaga and M. Kamura and A. Ohtahara and Y. Nakamura and M. Osakada and M. Gen and M. Kahara and T. Yoshimoto and K. Mizuno and Y. Furukawa and A. Tokunaga and N. Sasaki and M. Matsumura and T. Furue and K. Iwasaki and K. Ichiki and S. Mizofuchi and T. Yokoi and W. Furumoto and T. Fukui and K. Fujino and A. Ohta and S. Ueda and Y. Kitami and T. Ohkura and M. Takeuchi and K. Yoshida and S. Nishiyama and R. Kawamoto and A. Kobaru and T. Endo and K. Kitano and Y. Hirooka and M. Tohaya and Y. Miyazaki and K. Onoyama and J. Miyagi and U. Kin and Y. Fujishima and A. Kuwahara and R. Shindo and Y. Satake and T. Moritsuka and T. Kuwahara and O. Hano and Y. Takagi and S. Suzuki and K. Abe and T. Sato and M. Kohno and T. Fujino and K. Wakayama and T. Aso and T. Goto and H. Ozaki and K. Ninomiya and Y. Inobe and S. Hamasaki and J. Inoue and S. Naomi and T. Iwaoka and T. Ono and Y. Muta and Y. Endo and H. Ohmori and M. Nagata and N. Wake and H. Kozawa and Y. Tomino and T. Ikeda and H. Yoshii and H. Nakamura and N. Fujimoto and T. Asato and M. Tozawa and R. Sunagawa and Y. Nakamura and H. Tomori and K. Takashiba",
year = "2007",
month = "1",
doi = "10.1080/10641960601096976",
language = "English",
volume = "29",
pages = "69--81",
journal = "Clinical and Experimental Hypertension",
issn = "1064-1963",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Progress report on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study

T2 - Status at February 2004

AU - Hosohata, Keiko

AU - Saito, Shin

AU - Asayama, Kei

AU - Ohkubo, Takayoshi

AU - Kikuya, Masahiro

AU - Metoki, Hirohito

AU - Obara, Taku

AU - Kato, Tetsuo

AU - Hashimoto, Junichiro

AU - Totsune, Kazuhito

AU - Miura, Yukio

AU - Imai, Yutaka

AU - Arakawa, Kikuo

AU - Fujishima, Masatoshi

AU - Fujii, Jun

AU - Fukiyama, Koushiro

AU - Hisamichi, Shigeru

AU - Iimura, Osamu

AU - Ishii, Masao

AU - Omae, Teruo

AU - Saruta, Takao

AU - Yoshinaga, Kaoru

AU - Abe, Isao

AU - Abe, Kouji

AU - Abukawa, Teruo

AU - Ashida, Terunao

AU - Dohba, Nobutaka

AU - Etoh, Tanenao

AU - Fujimura, Akio

AU - Fujita, Toshiro

AU - Fukui, Akio

AU - Gotoh, Toshikazu

AU - Hama, Hitoshi

AU - Hano, Takuzo

AU - Hayashi, Hiroshi

AU - Hayashida, Noriaki

AU - Hayashi, Masato

AU - Hiramori, Katsuhiko

AU - Hirai, Yasunobu

AU - Hirata, Yukio

AU - Hiwada, Kunio

AU - Hora, Kazuhito

AU - Ichikawa, Shuichi

AU - Iida, Toshiho

AU - Ikeda, Toshio

AU - Imaizumi, Tsutomu

AU - Ishikawa, Kinji

AU - Ito, Ichisuke

AU - Ito, Masaaki

AU - Ito, Sadayoshi

AU - Iwaoka, Daisuke

AU - Kanamasa, Ken

AU - Katagiri, Takashi

AU - Katayama, Shigehiro

AU - Kawamura, Hiroshi

AU - Kawano, Yuhei

AU - Kida, Hiroshi

AU - Kikuchi, Kenjiro

AU - Kimura, Genjiro

AU - Kimura, Kenjiro

AU - Kitaoka, Hiroshi

AU - Kobayashi, Shoutai

AU - Kohara, Katsuhiko

AU - Kojima, Shunichi

AU - Komuro, Issei

AU - Kumagai, Hiroo

AU - Kumagai, Yuji

AU - Kusano, Eiji

AU - Kushiro, Toshio

AU - Kuwajima, Iwao

AU - Maruyama, Yukio

AU - Masani, Fumiaki

AU - Matsubara, Hiroaki

AU - Matsubara, Tatsuaki

AU - Matsumoto, Masayasu

AU - Matsuoka, Hiroaki

AU - Matsuura, Hideo

AU - Mishima, Yasuo

AU - Miura, Mamoru

AU - Miyamori, Isamu

AU - Mori, Hideki

AU - Murakami, Hidenori

AU - Muratani, Hiromi

AU - Nakagawa, Motoya

AU - Nakao, Kazuwa

AU - Naruse, Mitsuhide

AU - Nishio, Ichiro

AU - Ogihara, Toshio

AU - Ohta, Masahiro

AU - Ohtsuka, Kuniaki

AU - Ohtsuka, Youichi

AU - Ohuchi, Yasuyoshi

AU - Oikawa, Shinichi

AU - Okabe, Masaaki

AU - Okumura, Ken

AU - Saitoh, Ikuo

AU - Saitoh, Hisao

AU - Sakata, Toshiie

AU - Saku, Keijiro

AU - Sasaki, Hidetada

AU - Seino, Masahide

AU - Senda, Shouichi

AU - Shimada, Kazuyuki

AU - Shimamoto, Kazuaki

AU - Shimizu, Mitsuyuki

AU - Shiomi, Toshiaki

AU - Shirato, Kunio

AU - Sone, Masayoshi

AU - Suzuki, Hiromichi

AU - Suzuki, Shin

AU - Takahashi, Hakuo

AU - Takada, Masanobu

AU - Takeda, Kazuo

AU - Takeda, Noriyuki

AU - Takeshita, Akira

AU - Takishita, Shuichi

AU - Tanaka, Shigemichi

AU - Toba, Kenji

AU - Tochikubo, Osamu

AU - Tomoike, Hitonobu

AU - Ueno, Yuji

AU - Umemura, Satoshi

AU - Urata, Hidenori

AU - Watanabe, Takeshi

AU - Yamada, Kenichi

AU - Yamaguchi, Tohru

AU - Yamakado, Minoru

AU - Yamamoto, Yasumasa

AU - Yamamoto, Yoshiharu

AU - Yamashina, Akira

AU - Yokoyama, Hitoshi

AU - Yoshimura, Manabu

AU - Satoh, Hiroshi

AU - Oka, Yoshitomo

AU - Katagiri, Hideki

AU - Kondo, Yoshiaki

AU - Shishido, Hisayasu

AU - Kohinata, Akiko

AU - Kanno, Yohko

AU - Ikeda, Hiroko

AU - Takahira, Yuri

AU - Takahashi, Takahito

AU - Kimura, Atsushi

AU - Funahashi, Jin

AU - Takada, Noriko

AU - Hanazawa, Tomohiro

AU - Suzuki, Naoko

AU - Osugi, Motoko

AU - Hashimoto, Juinichiro

AU - Ogawa, Y.

AU - Miyamura, T.

AU - Masuda, Y.

AU - Tanaka, S.

AU - Tanaka, S.

AU - Koizumi, M.

AU - Ando, T.

AU - Endo, T.

AU - Tsuchida, A.

AU - Nanba, M.

AU - Yonekura, S.

AU - Shiroishi, M.

AU - Nakagawa, M.

AU - Ito, K.

AU - Oda, K.

AU - Takahashi, K.

AU - Kanahara, I.

AU - Hirota, N.

AU - Tsutsui, M.

AU - Anzai, J.

AU - Hosoda, S.

AU - Shiiki, M.

AU - Takagawa, Y.

AU - Iida, M.

AU - Tada, M.

AU - Noto, T.

AU - Tanaka, H.

AU - Tajima, G.

AU - Kawamorita, K.

AU - Kikuchi, K.

AU - Suzuki, H.

AU - Suzuki, K.

AU - Komai, K.

AU - Seki, H.

AU - Omoto, A.

AU - Takahashi, H.

AU - Kitabayashi, A.

AU - Kimura, M.

AU - Kimura, Y.

AU - Yamamoto, H.

AU - Takahashi, K.

AU - Kimura, H.

AU - Kawamorita, Y.

AU - Emura, Y.

AU - Suzuki, Y.

AU - Ishikawa, Y.

AU - Nagai, K.

AU - Nagai, S.

AU - Ito, T.

AU - Nihei, K.

AU - Yamada, S.

AU - Goto, T.

AU - Yamamoto, N.

AU - Suzuki, Y.

AU - Ito, H.

AU - Ito, M.

AU - Fujita, T.

AU - Tominaga, Y.

AU - Tominaga, S.

AU - Suzuki, K.

AU - Ishibashi, K.

AU - Ando, Y.

AU - Sato, S.

AU - Morikawa, H.

AU - Kashima, S.

AU - Nakayama, D.

AU - Hayashi, Y.

AU - Ohta, K.

AU - Metoki, H.

AU - Fukami, K.

AU - Hayashi, T.

AU - Kishi, M.

AU - Tajima, J.

AU - Seino, J.

AU - Hoshi, H.

AU - Imai, Y.

AU - Kimura, H.

AU - Mori, R.

AU - Matsuo, K.

AU - Tanno, Y.

AU - Shibasaki, A.

AU - Yamagishi, T.

AU - Ohtomo, E.

AU - Ohtsuka, Y.

AU - Sasaki, S.

AU - Seino, M.

AU - Kurosawa, K.

AU - Ito, K.

AU - Takagi, Y.

AU - Kyogoku, S.

AU - Ito, K.

AU - Ono, Y.

AU - Watanabe, M.

AU - Watanabe, S.

AU - Hiwatashi, N.

AU - Yagi, C.

AU - Unakami, H.

AU - Asayama, K.

AU - Mouri, T.

AU - Watanabe, T.

AU - Kikuchi, K.

AU - Maruyama, N.

AU - Sone, M.

AU - Iwamoto, M.

AU - Naganuma, S.

AU - Mashiko, H.

AU - Ishii, H.

AU - Takaya, Y.

AU - Kamimoto, M.

AU - Shirai, A.

AU - Watanabe, R.

AU - Tohyama, Y.

AU - Araki, F.

AU - Sakuma, H.

AU - Amada, Y.

AU - Sato, E.

AU - Techigawara, M.

AU - Nakamura, K.

AU - Nakayama, T.

AU - Hasegawa, Kazuhiro

AU - Hasegawa, K.

AU - Nagao, T.

AU - Minami, J.

AU - Kumagai, Y.

AU - Cho, T.

AU - Okamoto, K.

AU - Iguchi, T.

AU - Honzawa, T.

AU - Koitabashi, T.

AU - Yamada, T.

AU - Horikoshi, H.

AU - Nagao, T.

AU - Yoshimatsu, H.

AU - Seki, K.

AU - Akiyama, N.

AU - Suga, H.

AU - Matsunaga, R.

AU - Sinozaki, T.

AU - Ishimaru, Y.

AU - Yagi, N.

AU - Takikawa, H.

AU - Hukutome, T.

AU - Nakajima, C.

AU - Sato, H.

AU - Simizu, J.

AU - Arai, M.

AU - Koide, H.

AU - Takada, H.

AU - Sato, T.

AU - Umezu, T.

AU - Aoki, H.

AU - Nakamoto, H.

AU - Komahashi, K.

AU - Sekiya, S.

AU - Sugimoto, H.

AU - Arai, T.

AU - Suzuki, H.

AU - Inokuma, S.

AU - Funazaki, T.

AU - Yasuda, F.

AU - Kanouzawa, S.

AU - Yokota, C.

AU - Noguchi, Y.

AU - Hatano, M.

AU - Izumida, T.

AU - Hara, T.

AU - Muranaka, H.

AU - Suzuki, M.

AU - Ogawa, Y.

AU - Yabumoto, E.

AU - Matsushita, S.

AU - Kohzu, K.

AU - Sasaki, F.

AU - Hata, N.

AU - Yanagisawa, M.

AU - Ueda, T.

AU - Kurosawa, M.

AU - Doutare, S.

AU - Higashi, S.

AU - Kato, M.

AU - Hoshino, T.

AU - Fukuda, K.

AU - Ohtsuki, K.

AU - Ikeda, T.

AU - Kasatani, T.

AU - Yamada, T.

AU - Yatagai, S.

AU - Ohsuga, E.

AU - Yamakado, M.

AU - Kawamura, H.

AU - Mitsubayashi, H.

AU - Yamashina, S.

AU - Yamazaki, J.

AU - Nanjo, S.

AU - Ito, S.

AU - Teramoto, T.

AU - Gomi, T.

AU - Kato, S.

AU - Koekawa, N.

AU - Kuwaki, K.

AU - Ikeda, T.

AU - Hori, K.

AU - Arai, S.

AU - Koyama, H.

AU - Ichikawa, M.

AU - Hashimoto, A.

AU - Mori, H.

AU - Abe, S.

AU - Ohba, Y.

AU - Kurata, F.

AU - Miyakawa, M.

AU - Kimura, K.

AU - Hatori, Y.

AU - Ushiyama, M.

AU - Yamamoto, H.

AU - Adachi, M.

AU - Takayama, K.

AU - Shimizu, M.

AU - Iida, T.

AU - Asato, S.

AU - Uchiba, K.

AU - Watanabe, N.

AU - Kotani, M.

AU - Akaoka, F.

AU - Takahashi, S.

AU - Hirahara, K.

AU - Suzuki, S.

AU - Yamaguchi, Y.

AU - Ishikawa, S.

AU - Sasaki, K.

AU - Terada, Y.

AU - Ohhashi, S.

AU - Sakamaki, A.

AU - Hifumi, N.

AU - Ohno, T.

AU - Saeki, T.

AU - Suzaki, Y.

AU - Yamamoto, H.

AU - Nakagawa, T.

AU - Tomoda, F.

AU - Nishino, H.

AU - Ise, T.

AU - Takakuwa, H.

AU - Yokoyama, H.

AU - Kitakawa, S.

AU - Takasawa, K.

AU - Ohkura, T.

AU - Yamamoto, Y.

AU - Satake, K.

AU - Arai, Y.

AU - Nakayama, H.

AU - Sugiyama, S.

AU - Sugiura, K.

AU - Yokoyama, M.

AU - Ito, A.

AU - Okazaki, K.

AU - Saito, R.

AU - Mihara, J.

AU - Naito, A.

AU - Takahira, Y.

AU - Mori, T.

AU - Watanabe, M.

AU - Asai, S.

AU - Nojiri, O.

AU - Sakakura, K.

AU - Kozuka, M.

AU - Oyama, Y.

AU - Kawamura, Y.

AU - Inoko, T.

AU - Takeuchi, N.

AU - Tatematsu, H.

AU - Hayakawa, Y.

AU - Adachi, N.

AU - Tamagaki, N.

AU - Nakamura, T.

AU - Fukui, A.

AU - Amenomori, M.

AU - Kanaya, T.

AU - Masui, A.

AU - Hayashi, K.

AU - Nishi, S.

AU - Amari, M.

AU - Yoshida, K.

AU - Matsushita, Y.

AU - Sawada, S.

AU - Fujiwara, M.

AU - Ono, S.

AU - Tamai, K.

AU - Takemoto, Y.

AU - Kanemasa, T.

AU - Takenaka, T.

AU - Kitayama, K.

AU - Yasui, K.

AU - Fujita, S.

AU - Terayama, Y.

AU - Kato, N.

AU - Nagai, M.

AU - Takashima, H.

AU - Watanabe, K.

AU - Hirobe, N.

AU - Miyamoto, M.

AU - Sakamoto, N.

AU - Kurimoto, Y.

AU - Suzuki, N.

AU - Katsuya, S.

AU - Katsuya, T.

AU - Nagao, K.

AU - Nakamuta, K.

AU - Goto, S.

AU - Ueda, T.

AU - Imai, N.

AU - Sano, I.

AU - Ueda, H.

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AU - Takashiba, K.

PY - 2007/1

Y1 - 2007/1

N2 - The Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) Study is the first large-scale intervention trial in Japan using a PROBE design to determine an optimal target blood pressure (BP) level on the basis of self-measured BP at home and optimal initial antihypertensive medication. The registered patients are randomized to one of two different BP levels and to initial antihypertensive regimens (i.e., calcium antagonist [Ca-A], angiotensin-converting enzyme inhibitor [ACE-I], or angiotensin II receptor antagonist [ARB]).At the end of February 2004, 2729, 1687, and 971 patients were recruited, randomized, and followed-up for 12 months or more. Among the 971 patients, mean systolic/diastolic BP levels at randomization in the Ca-A, ACE-I, and ARB groups were 150/90, 152/89, and 151/89 mmHg, respectively. These values reduced after six months of Ca-A-, ACE-I-, and ARB-based treatment (133/81 mmHg, 135/80 mmHg, and 134/79 mmHg, respectively) and further reduced after 12 months (131/80 mmHg, 134/79 mmHg, and 132/79 mmHg, respectively) without any significant differences among groups. In more intensive and less intensive BP-lowering groups, mean systolic/diastolic BP levels at randomization were 151/90 and 150/89 mmHg, respectively. Although BP levels reduced after 6-month (135/80 mmHg and 133/80 mmHg, respectively) and 12-month treatment (133/79 mmHg and 132/80 mmHg, respectively) in each target group, no significant difference in BP values was observed between groups. These results indicate the necessity of additional interventional strategies to improve the achievement of target BP levels, especially in the more intensive BP-lowering group.

AB - The Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) Study is the first large-scale intervention trial in Japan using a PROBE design to determine an optimal target blood pressure (BP) level on the basis of self-measured BP at home and optimal initial antihypertensive medication. The registered patients are randomized to one of two different BP levels and to initial antihypertensive regimens (i.e., calcium antagonist [Ca-A], angiotensin-converting enzyme inhibitor [ACE-I], or angiotensin II receptor antagonist [ARB]).At the end of February 2004, 2729, 1687, and 971 patients were recruited, randomized, and followed-up for 12 months or more. Among the 971 patients, mean systolic/diastolic BP levels at randomization in the Ca-A, ACE-I, and ARB groups were 150/90, 152/89, and 151/89 mmHg, respectively. These values reduced after six months of Ca-A-, ACE-I-, and ARB-based treatment (133/81 mmHg, 135/80 mmHg, and 134/79 mmHg, respectively) and further reduced after 12 months (131/80 mmHg, 134/79 mmHg, and 132/79 mmHg, respectively) without any significant differences among groups. In more intensive and less intensive BP-lowering groups, mean systolic/diastolic BP levels at randomization were 151/90 and 150/89 mmHg, respectively. Although BP levels reduced after 6-month (135/80 mmHg and 133/80 mmHg, respectively) and 12-month treatment (133/79 mmHg and 132/80 mmHg, respectively) in each target group, no significant difference in BP values was observed between groups. These results indicate the necessity of additional interventional strategies to improve the achievement of target BP levels, especially in the more intensive BP-lowering group.

KW - Blood pressure measurement at home

KW - Hypertension

KW - Internet

KW - Prospective randomized open-label blinded-endpoint (PROBE)

KW - Randomized controlled trial (RCT)

UR - http://www.scopus.com/inward/record.url?scp=33846016213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846016213&partnerID=8YFLogxK

U2 - 10.1080/10641960601096976

DO - 10.1080/10641960601096976

M3 - Article

VL - 29

SP - 69

EP - 81

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

SN - 1064-1963

IS - 1

ER -