Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier

Shinta Mizuno, Yoshiyuki Yamagishi, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Mai Katahira, Aya Sasaki, Michiie Sakamoto, Hidekazu Suzuki, Takanori Kanai, Toshifumi Hibi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A 58-year-old man was diagnosed as a hepatitis B virus (HBV) carrier approximately 30 years ago. He was diagnosed with renal cell carcinoma when he was 57 years old. Radical nephrectomy was performed, and everolimus was administered to treat his lung metastasis. After beginning the everolimus, intermittent fever, general fatigue, and jaundice developed. He was admitted under a diagnosis of flare (acute exacerbation) of chronic B hepatitis due to HBV reactivation. Despite intensive care, he died of hepatic failure and fungus infection. The autopsy findings were compatible with hepatic failure due to HBV reactivation by everolimus. Antiviral prophylaxis must be taken into consideration before beginning immunosuppressive therapy such as everolimus in HBV carriers.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalClinical Journal of Gastroenterology
Volume6
Issue number2
DOIs
Publication statusPublished - 2013

Fingerprint

Liver Failure
Renal Cell Carcinoma
Hepatitis B virus
Mycoses
Chronic Hepatitis B
Critical Care
Immunosuppressive Agents
Jaundice
Nephrectomy
Antiviral Agents
Fatigue
Autopsy
Fever
Neoplasm Metastasis
Lung
Everolimus
Therapeutics

Keywords

  • Everolimus
  • Hepatitis B virus
  • Immunosuppressive therapy
  • Liver failure
  • Nucleoside analogue

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier. / Mizuno, Shinta; Yamagishi, Yoshiyuki; Ebinuma, Hirotoshi; Nakamoto, Nobuhiro; Katahira, Mai; Sasaki, Aya; Sakamoto, Michiie; Suzuki, Hidekazu; Kanai, Takanori; Hibi, Toshifumi.

In: Clinical Journal of Gastroenterology, Vol. 6, No. 2, 2013, p. 188-192.

Research output: Contribution to journalArticle

Mizuno, Shinta ; Yamagishi, Yoshiyuki ; Ebinuma, Hirotoshi ; Nakamoto, Nobuhiro ; Katahira, Mai ; Sasaki, Aya ; Sakamoto, Michiie ; Suzuki, Hidekazu ; Kanai, Takanori ; Hibi, Toshifumi. / Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier. In: Clinical Journal of Gastroenterology. 2013 ; Vol. 6, No. 2. pp. 188-192.
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AU - Katahira, Mai

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AU - Sakamoto, Michiie

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